Citation: Saima Perveen, Lulu Qin, Min Zhao, Zhengwei Ding, Yingying Wang, Zaicheng Nie, Pengfei Li. Recent development in radical cycloaddition reactions for the synthesis of carbo- and heterocycles[J]. Chinese Chemical Letters, ;2026, 37(1): 111886. doi: 10.1016/j.cclet.2025.111886 shu

Recent development in radical cycloaddition reactions for the synthesis of carbo- and heterocycles

Saima Perveen ^{a, 1,} ,
Lulu Qin ^{b, 1} ,
Min Zhao ^b ,
Zhengwei Ding ^c ,
Yingying Wang ^b ,
Zaicheng Nie ^b ,
Pengfei Li ^{a, b, *,}

a.
School of Chemistry, Xi’an Jiaotong University, Xi’an 710049, China
b.
Frontier Institute of Science and Technology and Interdisciplinary Research Centre of Frontier Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
c.
School of Pharmacy, Xi’an Jiaotong University, Xi’an 710049, China

saima.364@mail.xjtu.edu.cn

lipengfei@xjtu.edu.cn

Received Date: 19 June 2025
Revised Date: 23 August 2025
Accepted Date: 23 September 2025
Available Online: 25 September 2025

Figures(75)

Radical cycloaddition reactions (RCRs) are highly effective methods for constructing complex carbo- and heterocycles, which are frequently encountered in natural products that exhibit intriguing biological properties and hold significant potential for applications in medicinal chemistry. Radical-mediated cycloaddition strategies, which recycle radical character, are particularly appealing because they require only a catalytic amount of reagent and promise reactions with theoretically high atom economy. This review focuses on recent developments and synthetic applications in RCRs, with an emphasis on visible light-induced radical photocycloaddition reactions (RPCRs), transition metal-catalyzed approaches, and small molecule-catalyzed methods. By highlighting some outstanding innovations and addressing current challenges, this review aims to identify potential areas for improvement. These advancements will provide more efficient pathways for the synthesis of natural product molecules and offer valuable insights for the development of new synthetic methodologies.
- Radical cycloaddition,
- Carbo- and heterocycle,
- Visible-light photoaddition,
- Transition metal catalysis,
- Organic small molecule
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