Citation: Xiao-Yan Ran, Tian-Jian Xiong, Yu-Ping Yang, Zong-Hong Luo, Cheng Liu, Yu-Lan Zhu, Jun-Hui Zhang, Bang-Jin Wang, Sheng-Ming Xie, Li-Ming Yuan. Chiral porous liquid D-his-ZIF-8-[Bpy][NTf₂] for capillary gas chromatographic separation[J]. Chinese Chemical Letters, ;2026, 37(5): 111864. doi: 10.1016/j.cclet.2025.111864 shu

Chiral porous liquid D-his-ZIF-8-[Bpy][NTf₂] for capillary gas chromatographic separation

Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China

xieshengming_2006@163.com

Received Date: 18 April 2025
Revised Date: 31 July 2025
Accepted Date: 18 September 2025
Available Online: 18 September 2025

Figures(6)

Porous liquids (PLs), as a new class of porous materials with permanent porosity and liquid fluidity, have attracted extensive research interest due to their excellent physical and chemical properties. Herein, we synthesized a chiral porous liquid D-his-ZIF-8-[Bpy][NTf₂] based on a metal-organic framework (MOF) and used it as a new stationary phase to investigate its separation performance by high-resolution gas chromatography. The porosity of this porous liquid system was verified through Brunauer-Emmett-Teller (BET) and positron (e⁺) annihilation lifetime spectroscopy (PALS). The results showed that the D-his-ZIF-8-[Bpy][NTf₂] coated capillary column (column A) exhibited excellent separation performance for n-alkanes, n-alcohols, alkylbenzens, isomers, and racemic compounds. Among them, fifteen pairs of enantiomers including alcohols, esters, epoxides, ketones, haloalkanes, and amino acid derivatives were well separated on column A with good reproducibility and stability. The relative standard deviations (RSDs) of the retention time and peak area of two analytes (3-butyne-2-ol and dichlorobenzene) were <1.80% and 0.80%, respectively. By comparing the chiral recognition ability of D-his-ZIF-8-[Bpy][NTf₂] coated column A with D-his-ZIF-8 coated column B, the column A has better separation efficiency for chiral compounds than column B. In addition, the chiral recognition ability of column A is complementary to that of commercially available β-DEX 120 column (column C). Compared with the commercial HP-35 column and the previously reported P5A-C10–2NH₂ column for the separation of organic mixtures and/or isomers, column A exhibits similar separation performance and has a good separation complementarity to these two columns. Hence, this work opens up a new way for the practical application of porous framework solid materials in gas chromatography.
- Chiral porous liquid,
- Chiral stationary phase,
- Chiral separation,
- Gas chromatography
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Chiral porous liquid D-his-ZIF-8-[Bpy][NTf2] for capillary gas chromatographic separation

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Chiral porous liquid D-his-ZIF-8-[Bpy][NTf₂] for capillary gas chromatographic separation