Citation: Canghai Luo, Chao Wu, Baoling Guo, Yuan Zheng, Ze Yang, Xiaoying Ji, Jianpeng Sheng, Jian Ruan, Peng Zhao, Dongliang Li, Dong Chen. Controlled encapsulation of solid particles in core-shell capsules by millifluidics and assisted by vibrations[J]. Chinese Chemical Letters, ;2026, 37(7): 111749. doi: 10.1016/j.cclet.2025.111749 shu

Controlled encapsulation of solid particles in core-shell capsules by millifluidics and assisted by vibrations

Canghai Luo ^{a, b, 1} ,
Chao Wu ^{c, 1} ,
Baoling Guo ^d ,
Yuan Zheng ^{a, b} ,
Ze Yang ^b ,
Xiaoying Ji ^e ,
Jianpeng Sheng ^a ,
Jian Ruan ^a ,
Peng Zhao ^a ,
Dongliang Li ^{e, *,} ,
Dong Chen ^{a, b, *,}

a.
Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
b.
College of Energy Engineering and State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310003, China
c.
Department of Medical Oncology, Senior Department of Oncology, Chinese PLA General Hospital, Beijing 100853, China
d.
Department of Oncology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China
e.
Cigar Fermentation Technology Key Laboratory of China Tobacco, China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610100, China

360188228@qq.com

chen_dong@zju.edu.cn

Received Date: 13 May 2025
Revised Date: 19 August 2025
Accepted Date: 21 August 2025
Available Online: 22 August 2025

Figures(5)

Core-shell capsules are excellent carriers, showing good performances in cargo protection and controlled release. However, the controlled encapsulation of solid particles in capsules remains a great challenge, severely limiting their widespread applications. Here, a millifluidic system assisted by periodic vibrations is developed to precisely control the preparation of particle-loaded capsules. A high-frequency low-amplitude vibration is applied to prevent the jamming of solid particles by shaking and a low-frequency high-amplitude vibration is applied to synchronize the feeding of solid particles and the emulsification of capsules by generating a periodic flow pulse. The phase diagrams of particle-loaded capsules are systematically investigated with respect to various experimental parameters to provide guidances for the controlled preparation process. The developed millifluidic system offers a versatile platform to precisely prepare core-shell capsules loaded with different sizes, types and numbers of particles. The prepared particle-loaded capsules possess good biocompatibility, monodispersity, mechanical strength, storage stability and controlled release, paving the way for their widespread applications.
- Capsule,
- Core-shell,
- Millifluidics,
- Encapsulation,
- Vibration-assisted
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1.
沈阳化工大学材料科学与工程学院沈阳 110142