Citation: Yongli Zhao, Dingsheng Cao, Jie-Ping Wan, Yunyun Liu. Synthesis of 3-phosphinyl chromones via in situ iodination mediated C-H phosphination and the tunable synthesis of 2-phosphoryl chromanones[J]. Chinese Chemical Letters, ;2026, 37(1): 111740. doi: 10.1016/j.cclet.2025.111740 shu

Synthesis of 3-phosphinyl chromones via in situ iodination mediated C-H phosphination and the tunable synthesis of 2-phosphoryl chromanones

Yongli Zhao ^a ,
Dingsheng Cao ^a ,
Jie-Ping Wan ^{a, b, *,} ,
Yunyun Liu ^{a, *,}

a.
Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China
b.
International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China

wanjieping@jxnu.edu.cn

chemliuyunyun@jxnu.edu.cn

Received Date: 13 June 2025
Revised Date: 1 August 2025
Accepted Date: 17 August 2025
Available Online: 18 August 2025

Figures(5)

By means the in situ halogenation of the vinyl C-H bond in o-hydroxyphenyl enaminones, the step efficient synthesis of 3-diphenylphosphinyl chromones has been realized through the challenging construction of C-P(Ⅲ) bond by using diphenyl phosphine as reaction partner. In addition, the tunable synthesis of 2-phosphoryl chromanones has been achieved via hydrophosphorylation by simply modifying reaction conditions without using metal reagent.
- Enaminone,
- Chromone,
- Chromanone,
- Selectivity,
- In situ iodination,
- C-P bond formation
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