Citation: Peishuang Yu, Bohan Chen, Bingyu Xie, Mengjiao Zhou, Chengying Wang, Shenshen Yang, Wei Huang, Yubo Li. Recent advances in oral hydrogel drug delivery system for disease treatment[J]. Chinese Chemical Letters, ;2026, 37(7): 111695. doi: 10.1016/j.cclet.2025.111695 shu

Recent advances in oral hydrogel drug delivery system for disease treatment

Peishuang Yu ^a ,
Bohan Chen ^b ,
Bingyu Xie ^c ,
Mengjiao Zhou ^a ,
Chengying Wang ^a ,
Shenshen Yang ^{a, *,} ,
Wei Huang ^{b, *,} ,
Yubo Li ^{a, *,}

a.
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
b.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
c.
Dongfang Zhenmei (Beijing) Technology Development Co., Ltd., Beijing 100070, China

shine2099@163.com

huangwei@imm.ac.cn

yaowufenxi001@sina.com

Received Date: 12 May 2025
Revised Date: 4 August 2025
Accepted Date: 9 August 2025
Available Online: 9 August 2025

Figures(7)

With growing emphasis on drug efficacy, safety, and adverse reactions, many traditional Chinese medicines and their active ingredients, as well as compounds such as antibiotics, immunosuppressants, and hormones often face limited efficacy or give rise to adverse effects during application. To improve therapeutic outcomes and reduce systemic side effects, oral targeted drug delivery systems have become an important research direction. Hydrogels have shown great potential in the field of oral delivery to treat many diseases due to their superior drug protection ability and excellent biocompatibility. This review explores the physiological characteristics of the gastrointestinal tract and the significant advantages of oral hydrogels in drug delivery, and systematically introduces hydrogel carrier design strategies through physical crosslinking, chemical crosslinking, small molecule self-assembly, and metal ion coordination. Furthermore, it emphasizes recent advances in intelligent oral hydrogels and drug loading strategy. Lastly, the review summarizes the innovative applications of oral hydrogels in the treatment of diseases such as esophagitis, GI disorders, metabolic and endocrine diseases, osteoporosis, detoxification, and cardiovascular diseases, offering valuable insights and guidance for optimizing and advancing hydrogel-based drug delivery systems.
- Hydrogels,
- Oral delivery,
- Drug delivery,
- Intelligent system,
- Controlled release
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沈阳化工大学材料科学与工程学院沈阳 110142