Citation: Zhixuan Li, Xinying Wang, Han Wu, Qingxiang Guan. Advances in preparation and modification strategies of CeO₂ nanozymes and potential clinical applications[J]. Chinese Chemical Letters, ;2026, 37(7): 111671. doi: 10.1016/j.cclet.2025.111671 shu

Advances in preparation and modification strategies of CeO₂ nanozymes and potential clinical applications

School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

guanqx@jlu.edu.cn

Received Date: 9 June 2025
Revised Date: 30 July 2025
Accepted Date: 2 August 2025
Available Online: 7 August 2025

Figures(7)

Cerium oxide nanozymes (CeO₂ NZs) exhibit enzyme mimetic activities and great promise for biomedical applications by mediating the dynamic cycling between Ce³⁺ and Ce⁴⁺. However, traditional preparation methods are often expensive and detrimental to the environment. Meanwhile, the problems of easy agglomeration, poor targeting and weak biocompatibility need to be solved. The available literatures have mainly reviewed CeO₂ NZs in terms of its material properties, mechanisms and potential clinical applications. The literatures on the limitations of CeO₂ NZs and the corresponding improvement methods are fragmented. Consequently, the limitations of CeO₂ NZs and the strategies involving green preparation technology and modification mainly summarized, while the biosafety of the modification strategies are compared. Meanwhile, representative studies of potential clinical applications of CeO₂ NZs over the past three years are outlined, along with a summary of their clinical translational prospects and challenges. Finally, the challenges of CeO₂ NZs promotion technology are discussed.
- Cerium oxide,
- Nanozymes,
- Green preparation methods,
- Modification strategies,
- Clinical applications
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Advances in preparation and modification strategies of CeO2 nanozymes and potential clinical applications

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Advances in preparation and modification strategies of CeO₂ nanozymes and potential clinical applications