Citation: Zhong Du, Li-Jun Zhu, Jia-Bao Xiong, Yu-Xiang Gao, Ya-Qi Cui, Maierhaba Aili, Chen-Yang Chu, Chi Zhang, Gao-Fei Huang, Xue-Liang Zhang, Nuernisha Alifu, Biao Dong. Multifunctional FA-PDA@ICG-Bi₂Se₃ nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer[J]. Chinese Chemical Letters, ;2026, 37(4): 111488. doi: 10.1016/j.cclet.2025.111488 shu

Multifunctional FA-PDA@ICG-Bi₂Se₃ nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer

Zhong Du ^{a, 1} ,
Li-Jun Zhu ^{a, 1} ,
Jia-Bao Xiong ^a ,
Yu-Xiang Gao ^a ,
Ya-Qi Cui ^{b, c} ,
Maierhaba Aili ^d ,
Chen-Yang Chu ^d ,
Chi Zhang ^e ,
Gao-Fei Huang ^c ,
Xue-Liang Zhang ^c ,
Nuernisha Alifu ^{a, c, *,} ,
Biao Dong ^{b, c, *,}

a.
The Second Affiliated Hospital of Xinjiang Medical University, The Second School of Clinical Medicine, Xinjiang Medical University, Urumqi 830054, China
b.
State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering, Jilin University, Changchun 130012, China
c.
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830011, China
d.
State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
e.
Department of Labor Hygiene and Environmental Hygiene, School of Public Health, Xinjiang Medical University, Urumqi 830054, China

nens_xjmu@126.com

dongb@jlu.edu.cn

Received Date: 27 March 2025
Revised Date: 16 June 2025
Accepted Date: 18 June 2025
Available Online: 19 June 2025

Figures(5)

Cervical cancer remains a leading cause of cancer-related mortality in women, underscoring the urgent need for advanced diagnostic and therapeutic strategies. Current imaging techniques face significant limitations, including radiation exposure, high costs, and inadequate sensitivity for detecting early metastases, particularly in imaging and diagnosing tumor metastatic lesions. To overcome these challenges, we developed a multimodal imaging strategy that combined near-infrared fluorescence (NIRF, 750–1700 nm) imaging with X-ray imaging, with assistance of innovative nanomaterial to achieve precise tumor targeting and comprehensive diagnostic. Specifically, we synthesized a folate acid-functionalized polydopamine-modified ICG-Bi₂Se₃ nanocomposite (FA-PDA@ICG-Bi₂Se₃, FPBI), which integrated the complementary advantages of NIRF, X-ray, and computerized tomography imaging. The FPBI nanocomposite leveraged the targeting capability of folate acid for specific identification of cervical cancer lesions and metastatic lymph node. Furthermore, it demonstrated robust photothermal therapeutic efficacy under near-infrared (808 nm) excitation, achieving significant tumor ablation effects. This work provides an innovative nanoplatform based strategy for multimodal imaging, precise diagnosis, and targeted therapy of cervical cancer, paving the way for improved detection and management of metastatic lesions.
- NIR fluorescent imaging,
- Active targeting,
- Dual-modal imaging,
- Metastasis,
- Photothermal therapy
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Multifunctional FA-PDA@ICG-Bi2Se3 nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer

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通讯作者: 陈斌, bchen63@163.com

Multifunctional FA-PDA@ICG-Bi₂Se₃ nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer