Citation: Xiao-Kai Li, Si-Hao Fu, Yi Yue, Rui-Jing Pang, Jia Feng, Ren-Rong Liu. C₂-Symmetric N–N atropisomeric diphosphines: Synthesis and application in enantioselective dearomatization of heteroaryls[J]. Chinese Chemical Letters, ;2026, 37(5): 111430. doi: 10.1016/j.cclet.2025.111430 shu

C₂-Symmetric N–N atropisomeric diphosphines: Synthesis and application in enantioselective dearomatization of heteroaryls

Xiao-Kai Li ^{a, 1} ,
Si-Hao Fu ^{a, 1} ,
Yi Yue ^a ,
Rui-Jing Pang ^a ,
Jia Feng ^{a, *,} ,
Ren-Rong Liu ^{a, b, *,}

a.
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China
b.
College of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China

jfeng@qdu.edu.cn

renrongliu@qdu.edu.cn

Received Date: 18 March 2025
Revised Date: 22 May 2025
Accepted Date: 8 June 2025
Available Online: 9 June 2025

Figures(7)

Although C₂-symmetric C–C atropisomeric diphosphines such as BINAP and SEGPHOS, have achieved tremendous success in enantioselective catalysis in recent centuries, developing diphosphines based on new structural scaffolds is still highly desirable. Here, C₂-symmetric N–N atropisomeric diphosphines have been synthesized and comprehensively analyzed. These diphosphines exhibit excellent substituent-dependent tunable dihedral angles comparable to other useful electron-enriched diphosphines. With the aid of these newly developed diphosphines, the transition-metal catalyzed enantioselective dearomatization of heteroaryls is carried out to yield final products with excellent enantioselectivities, indicating their exceptional stereoinduction abilities.
- N-N Atropisomers,
- Chiral diphosphines,
- Enantioselective dearomatization,
- Axially chiral synthesis,
- Enantioselective catalysis
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C2-Symmetric N–N atropisomeric diphosphines: Synthesis and application in enantioselective dearomatization of heteroaryls

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C₂-Symmetric N–N atropisomeric diphosphines: Synthesis and application in enantioselective dearomatization of heteroaryls