Citation: Siyi Lin, Qingxue Xu, Xuguan Bai, Zhennan Tian, Lu Wang, Fuxin Han, Shigui Chen, Qiang Cai. Halogen-bonded organic frameworks (XOFs) based on [N···Br⁺···N] bonds for enhanced photothermal cancer therapy[J]. Chinese Chemical Letters, ;2026, 37(1): 111425. doi: 10.1016/j.cclet.2025.111425 shu

Halogen-bonded organic frameworks (XOFs) based on [N···Br⁺···N] bonds for enhanced photothermal cancer therapy

Siyi Lin ^{a, 1} ,
Qingxue Xu ^{b, 1} ,
Xuguan Bai ^{a, 1} ,
Zhennan Tian ^a ,
Lu Wang ^a ,
Fuxin Han ^{c, *,} ,
Shigui Chen ^{a, *,} ,
Qiang Cai ^{b, *,}

a.
The Institute for Advanced Studies, Hubei Key Lab on Organic and Polymeric Opto-Electronic Materials, Wuhan University, Wuhan 430072, China
b.
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China
c.
Neurological intensive care unit, Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China

93501192@qq.com

caiqno@whu.edu.cn

sgchen@whu.edu.cn

Received Date: 19 February 2025
Revised Date: 12 May 2025
Accepted Date: 6 June 2025
Available Online: 7 June 2025

Figures(6)

Effective treatment of subcutaneous tumors remains a focal point in cancer therapy. Photothermal therapy, a novel therapeutic approach, has emerged as a promising alternative, offering a less invasive option for the treatment of subcutaneous tumors. This study reports the exploration of novel supramolecular halogen-bonded organic frameworks (XOFs) based on [N···Br⁺···N] halogen bonds through the ligand exchange strategy and their application in photothermal therapy. Through ligand exchange, XOF(Br)-TPy was successfully prepared, and its structure and properties were thoroughly characterized using NMR, XPS, FT-IR, and XRD techniques. Due to their cationic characteristics, these XOFs serve as effective carriers for the photothermal agent IR820. In vitro experiments demonstrated that the IR820@XOF(Br)-TPy composite exhibits excellent photothermal conversion efficiency under NIR irradiation, effectively inducing tumor cell ablation. Furthermore, in vivo studies confirmed the remarkable antitumor efficacy of the composite material in a subcutaneous tumor model. This work demonstrates that the ligand exchange strategy is a versatile and facile approach for constructing XOFs(Br) and provides a novel strategy for developing advanced photothermal therapeutic agents with significant application potential.
- [N···Br⁺···N] halogen bond,
- Supramolecular medicine,
- Photothermal therapy,
- Tumor treatment
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沈阳化工大学材料科学与工程学院沈阳 110142

Halogen-bonded organic frameworks (XOFs) based on [N···Br+···N] bonds for enhanced photothermal cancer therapy

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通讯作者: 陈斌, bchen63@163.com

Halogen-bonded organic frameworks (XOFs) based on [N···Br⁺···N] bonds for enhanced photothermal cancer therapy