Citation: Zhi-Peng Zhou, Xin Wei, Ming Yan, Zhi-Guo Wang, Rui Hong, Jia-Zhuang Xu. Multifunctional selenium nanoparticles/gelatin-based nanocomposite hydrogel adhesive for accelerated full-thickness wound healing[J]. Chinese Chemical Letters, ;2025, 36(9): 111400. doi: 10.1016/j.cclet.2025.111400 shu

Multifunctional selenium nanoparticles/gelatin-based nanocomposite hydrogel adhesive for accelerated full-thickness wound healing

Zhi-Peng Zhou ^a ,
Xin Wei ^b ,
Ming Yan ^b ,
Zhi-Guo Wang ^c ,
Rui Hong ^{c, *,} ,
Jia-Zhuang Xu ^{b, c, *,}

a.
Faculty of Hepato-Biliary-Pancreatic Surgery, The First Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing 100853, China
b.
College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Chengdu 610065, China
c.
West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu 610041, China

hongrui@scu.edu.cn

jzxu@scu.edu.cn

Received Date: 18 March 2025
Revised Date: 27 May 2025
Accepted Date: 29 May 2025
Available Online: 9 June 2025

Figures(6)

Wound dressings with tissue adhesion, good mechanical, antioxidant and anti-inflammatory performance are urgently needed. In this work, we present a multifunctional selenium nanoparticles (SeNPs)/citric acid/gelatin/hydroxysuccinimide-grafted polyacrylic acid nanocomposite hydrogel adhesive (SCA) specifically designed for wound healing applications. The SCA was prepared via a one-pot processing, where SeNPs synthesized via chemical reduction were incorporated. These SeNPs not only endowed SCA with robust wet adhesion ability, excellent stretchability, and skin-matched elasticity modulus by serving as a physical crosslinker to modulate swelling equilibrium and molecular slippage, but also enhanced the biocompatibility and free radical scavenging capacity of SCA. Furthermore, in vivo evaluation of full-thickness cutaneous defects of rats revealed that SCA effectively reduced inflammation, promoted wound closure, and increased collagen deposition. All these results demonstrated that the developed SCA offers a promising therapeutic strategy for wound healing applications.
- Wet adhesive hydrogel,
- Wound healing,
- Selenium nanoparticles,
- Antioxidant,
- Anti-inflammatory
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沈阳化工大学材料科学与工程学院沈阳 110142