Citation: Ya-Jie Zhu, Zhi-Min Lv, Hao-Feng Zhu, Qi-Yan Qi, Shang-Bo Yu, Jia Tian, Wei Zhou, Zhan-Ting Li. Self-assembly of disassemblable supramolecular organic frameworks for doxorubicin delivery, photofrin posttreatment phototoxicity inhibition and heparin neutralization[J]. Chinese Chemical Letters, ;2026, 37(1): 111353. doi: 10.1016/j.cclet.2025.111353 shu

Self-assembly of disassemblable supramolecular organic frameworks for doxorubicin delivery, photofrin posttreatment phototoxicity inhibition and heparin neutralization

Ya-Jie Zhu ^a ,
Zhi-Min Lv ^a ,
Hao-Feng Zhu ^a ,
Qi-Yan Qi ^a ,
Shang-Bo Yu ^{a, *,} ,
Jia Tian ^a ,
Wei Zhou ^{b, *,} ,
Zhan-Ting Li ^{a, *,}

a.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200032, China
b.
Department of Chemistry, Fudan University, Shanghai 200438, China

yushbo@sioc.ac.cn

zhouw@fudan.edu.cn

ztli@mail.sioc.ac.cn

Received Date: 14 March 2025
Revised Date: 8 May 2025
Accepted Date: 19 May 2025
Available Online: 20 May 2025

Figures(5)

Two supramolecular organic frameworks (SOFs) have been constructed from the co-assembly of biimidazolium-derived octacationic components and cucurbit[8]uril in water. Dynamic light scattering and ¹H NMR experiments reveal that both SOFs can undergo reversible assembly and disassembly at room temperature. One of the SOFs displays unprecedently high maximum tolerated dose of 120 mg/kg with mice, which improves by 40% compared with the highest value of the reported SOFs. In vitro and in vivo tests show that the SOF can adsorb doxorubicin and overcome the resistance of multidrug-resistant MDR A549/ADR tumor cells to realize intracellular delivery, leading to enhanced antitumor efficacy. Moreover, it can also completely inhibit the posttreatment phototoxicity of photofrin and fully neutralize the anticoagulation of both unfractionated heparin and low molecular weight heparins through efficient inclusion and elimination or sequestration mechanism. As the first examples that undergo room-temperature reversible assembly and disassembly, the new SOFs in principle allow for quantitative analysis of the molecular components in the body that is prerequisite for preclinical evaluation in the future.
- Supramolecular organic framework,
- Self-assembly and disassembly,
- Biosafety,
- Drug delivery,
- Porphyrin phototoxicity inhibition,
- Heparin antagonism
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