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Citation: Junqi Su, Wenhao Liu, Jianjun Wang, Weifen Luo, Yangyang Ma, Leiyang Lv, Zhiping Li. Palladium-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane[J]. Chinese Chemical Letters, ;2026, 37(3): 111288. doi: 10.1016/j.cclet.2025.111288 shu

Palladium-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with fluoromalonates or fluorobis(phenylsulfonyl)methane

  • a.

    Key Laboratory of Advanced Light Conversion Materials and Biophotonics, School of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China

  • b.

    Fujian Yongjing Technology Co., Ltd., Shaowu 354003, China

  • c.

    College of Chemistry and Environmental Engineering, Pingdingshan University, Pingdingshan 467000, China

Figures(4)

  • Fluorine locates a pivotal position in modern medicinal chemistry due to its distinctive impact on the properties of organic molecules. This work described an efficient divergent palladium/XPhos-catalyzed ring-opening defluorinative cross-coupling of gem-difluorocyclopropanes with less nucleophilic fluorinated malonates or fluorobis(phenylsulfonyl)methane. The corresponding difluoro malonates and 2,4-difluorobutadienyl sulfones were obtained in good yields, respectively. Besides, this protocol also enabled the modification of structurally diverse complex molecules.
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