Citation: Minfei Yu, Yueyan Yang, Xin Cheng, Shicheng Pei, Man Wu, Fangling Cao, Yaxin Zheng, Shuyao Zhou, Keming Xu, Lei Zhou, Wenying Zhong. Orthogonal upconversion nanoplatform for in situ hydrogelation and photo-activatable chemotherapy[J]. Chinese Chemical Letters, ;2026, 37(5): 111284. doi: 10.1016/j.cclet.2025.111284 shu

Orthogonal upconversion nanoplatform for in situ hydrogelation and photo-activatable chemotherapy

Minfei Yu ^a ,
Yueyan Yang ^a ,
Xin Cheng ^a ,
Shicheng Pei ^a ,
Man Wu ^a ,
Fangling Cao ^a ,
Yaxin Zheng ^a ,
Shuyao Zhou ^a ,
Keming Xu ^{a, b, *,} ,
Lei Zhou ^{a, b, *,} ,
Wenying Zhong ^{a, b, *,}

a.
School of Science, China Pharmaceutical University, Nanjing 211198, China
b.
Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 211198, China

kmxu@cpu.edu.cn

leizhou@cpu.edu.cn

wyzhong@cpu.edu.cn

Received Date: 1 March 2025
Revised Date: 27 April 2025
Accepted Date: 30 April 2025
Available Online: 30 April 2025

Figures(5)

Light is a powerful tool for controlling hydrogel formation and drug release, which are essential in tissue engineering and drug delivery. Achieving orthogonal control over hydrogelation and drug release using different wavelengths of light offers precise spatiotemporal regulation but is challenged by limited penetration depth and spectral crosstalk of commonly used visible light. Herein, this work develops an orthogonal light-responsive hydrogel based on dual-wavelength upconversion nanoparticles (UCNPs) for controlled hydrogelation and drug release. Upon 808 nm excitation, these UCNPs emit green light, triggering the photopolymerization of hyaluronic acid-2-aminoethyl methacrylate hydrogels. While 980 nm induces ultraviolet emission, enabling controlled and sustained drug release. Through structural design, the emissions under dual-wavelength excitation exhibit no spectral crosstalk, enabling orthogonal light control of both processes. In vitro and in vivo experiments show that both hydrogel formation and drug release processes can be finely tuned by controlling the power density and excitation durations, significantly enhancing the spatiotemporal precision of drug delivery. This orthogonal light-responsive hydrogel holds significant potential for precise, spatiotemporally controlled drug delivery.
- Upconversion nanoparticles,
- Light-responsive,
- Photopolymerization hydrogel,
- Prodrug activation,
- Spatiotemporal drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142