Citation: Chuangchuang Liu, Yilian Song, Wenjie Ju, Xin Liu, Min Liang, Yingsheng Zhao. A highly efficient approach to Z-monofluoroolefin-dehydroamino acid derivatives from gem-difluoroalkenes[J]. Chinese Chemical Letters, ;2026, 37(4): 111167. doi: 10.1016/j.cclet.2025.111167 shu

A highly efficient approach to Z-monofluoroolefin-dehydroamino acid derivatives from gem-difluoroalkenes

Chuangchuang Liu ^{a, 1} ,
Yilian Song ^{a, 1} ,
Wenjie Ju ^{a, 1} ,
Xin Liu ^a ,
Min Liang ^a ,
Yingsheng Zhao ^{a, b, *,}

a.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical, Engineering and Materials Science, Soochow University, Suzhou 215123, China
b.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, China

yszhao@suda.edu.cn

Received Date: 28 December 2024
Revised Date: 18 March 2025
Accepted Date: 1 April 2025
Available Online: 2 April 2025

Figures(8)

Amino acids are the building blocks of proteins and various bioactive molecules. Fluorination is a key strategy in medicinal chemistry, making the development of new and efficient methods for fluorinating amino acids highly desirable. While many fluorination reagents have been developed, their application on amino acid frameworks remains limited. In this study, we demonstrate that ethyl 3-bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate is an effective gem-difluoroalkenes precursor for constructing a library of monofluoroolefin amino acids via a Pd-catalyzed cross-coupling reaction.
- Fluorinated amino acids,
- Novel gem-difluoroalkenes precursor,
- Suzuki coupling,
- Heck reaction,
- Late-stage functionalization
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