Citation: Xiaodan Liang, Tong Tong, Caihong Xian, Jiyuan Du, Biying Tan, Liying Wang, Jingyi Hou, Jun Wu. Metal-based biomaterials for treating bone diseases[J]. Chinese Chemical Letters, ;2026, 37(4): 111140. doi: 10.1016/j.cclet.2025.111140 shu

Metal-based biomaterials for treating bone diseases

Xiaodan Liang ^{a, b, 1} ,
Tong Tong ^{b, d, 1} ,
Caihong Xian ^{b, d, 1} ,
Jiyuan Du ^b ,
Biying Tan ^a ,
Liying Wang ^{b, *,} ,
Jingyi Hou ^{e, *,} ,
Jun Wu ^{a, b, c, *,}

a.
Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China
b.
Bioscience and Biomedical Engineering Thrust, Systems Hub, The Hong Kong University of Science and Technology (Guangzhou), Nansha, Guangzhou 511400, China
c.
Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong 999077, China
d.
Department of Hematology, Department of Orthopedics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China
e.
Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China

wangly53@mail2.sysu.edu.cn

houjy7@mail.sysu.edu.cn

junwuhkust@ust.hk

Received Date: 12 January 2025
Revised Date: 24 March 2025
Accepted Date: 25 March 2025
Available Online: 25 March 2025

Figures(5)

Bone-related diseases resulting from accidents, illnesses, and injuries have become increasingly common in recent years. Treating these conditions poses significant challenges, including prolonged recovery times, high costs, and unpredictable outcomes, which can lead to complications such as infections and reduced muscle strength. Although autologous bone transplantation is regarded as the "gold standard" for addressing bone diseases, its application is often limited by complications at the donor site and the risk of infection. This underscores the urgent need to explore alternatives to autogenous bone transplantation. In response, a range of biomaterials for bone repair have been developed, with metal-based biomaterials emerging as effective adjuncts that enhance and optimize the repair and regeneration of bone tissue. These materials can actively influence the bone repair process through mechanisms such as inductive osteogenesis, immunomodulation, and pro-angiogenesis. This review begins by highlighting the biological effects of metal-based biomaterials, followed by a comprehensive overview of their macro- and micro-scale classifications and applications for treating various bone diseases. Finally, the review addresses future directions and challenges associated with the use of metal-based biomaterials in bone repair, aiming to propose promising strategies for the treatment of bone-related diseases.
- Metal-based biomaterials,
- Bone diseases,
- Macro- and microscale,
- Biological effects,
- Treating bone diseases
1. [1]
  O. Ou, K. Huang, C. Fu, et al., Chem. Eng. J. 382 (2020) 123019. doi: 10.1016/j.cej.2019.123019
2. [2]
  S.J. Morrison, D.T. Scadden, Nature 505 (2014) 327–334. doi: 10.1038/nature12984
3. [3]
  Z. Yao, X. You, X. Wang, et al., Chin. Chem. Lett. 36 (2025) 110607. doi: 10.1016/j.cclet.2024.110607
4. [4]
  R. Phukan, T. Herzog, P.J. Boland, et al., Clin. Orthop. Relat. R 474 (2016) 687–696. doi: 10.1007/s11999-015-4361-3
5. [5]
  M. Majidinia, A. Sadeghpour, B. Yousefi, J. Cell. Physiol. 233 (2018) 2937–2948. doi: 10.1002/jcp.26042
6. [6]
  P. Habibovic, Tissue Eng. Part A 23 (2017) 1295–1296. doi: 10.1089/ten.tea.2017.0430
7. [7]
  D.D.M. Pereira, P. Habibovic, Adv. Healthc. Mater. 7 (2018) 1800700. doi: 10.1002/adhm.201800700
8. [8]
  G.L. Koons, M. Diba, A.G. Mikos, Nat. Rev. Mater. 5 (2020) 584–603. doi: 10.1038/s41578-020-0204-2
9. [9]
  E. Pariente, J.M. Olmos, R. Landeras, et al., J. Bone Miner. Metab. 35 (2017) 114–121. doi: 10.1007/s00774-016-0735-1
10. [10]
  B. Cimatti, M.A.D. Santos, M.S. Brassesco, et al., J. Biomed. Mater. Res. B 106 (2018) 649–658. doi: 10.1002/jbm.b.33870
11. [11]
  S.D. Tran, Y. Liu, D. Xia, et al., PLoS One 8 (2013) e61632. doi: 10.1371/journal.pone.0061632
12. [12]
  L.F. Amorosa, C.H. Lee, A.B. Aydemir, et al., Int. J. Nanomedcine 8 (2013) 1637–1643.
13. [13]
  A. Sakkas, F. Wilde, M. Heufelder, et al., Int. J. Implant Dent. 3 (2017) 23. doi: 10.1186/s40729-017-0084-4
14. [14]
  R. Dimitriou, G.I. Mataliotakis, A.G. Angoules, et al., Injury 42 (2011) S3–S15.
15. [15]
  R.J. Miron, R. Gruber, E. Hedbom, et al., Clin. Implant Dent. Relat. Res. 15 (2013) 481–489. doi: 10.1111/j.1708-8208.2012.00440.x
16. [16]
  P.V. Giannoudis, H. Dinopoulos, E. Tsiridis, Injury 36 (2005) S20–S27.
17. [17]
  A. Oryan, S. Alidadi, A. Moshiri, et al., J. Orthop. Surg. Res. 9 (2014) 18. doi: 10.1186/1749-799X-9-18
18. [18]
  Y. Liu, Q. Yu, J. Chang, et al., Nanoscale 11 (2019) 13678–13708. doi: 10.1039/c9nr02955a
19. [19]
  B. Chen, H. Xiang, S. Pan, et al., Adv. Funct. Mater. 30 (2020) 2002621. doi: 10.1002/adfm.202002621
20. [20]
  X. Li, X. Shu, Y. Shi, et al., Chin. Chem. Lett. 34 (2023) 107986. doi: 10.1016/j.cclet.2022.107986
21. [21]
  W. Guo, B. Li, P. Li, et al., J. Mater. Chem. B 11 (2023) 9572–9596. doi: 10.1039/d3tb01236k
22. [22]
  Z. Hao, L. Ren, Z. Zhang, et al., Bioact. Mater. 23 (2023) 206–222.
23. [23]
  P. Dec, A. Modrzejewski, A. Pawlik, Int. J. Mol. Sci. 24 (2022) 529. doi: 10.3390/ijms24010529
24. [24]
  J. Wang, X. Ma, Y. Feng, et al., Biol. Trace. Elem. Res. 179 (2017) 284–293. doi: 10.1007/s12011-017-0948-8
25. [25]
  C. Wu, P. Chen, T. Li, et al., BMC Complement. Med. Ther. 13 (2013) 277. doi: 10.1186/1472-6882-13-277
26. [26]
  X. Pan, M. Ou, Y. Lu, et al., Biomater. Adv. 152 (2023) 213503. doi: 10.1016/j.bioadv.2023.213503
27. [27]
  S. Franz, S. Rammelt, D. Scharnweber, et al., Biomaterials 32 (2011) 6692–6709. doi: 10.1016/j.biomaterials.2011.05.078
28. [28]
  Y. Luo, H. Liu, Y. Zhang, et al., Biomater. Sci. 11 (2023) 7268–7295. doi: 10.1039/d3bm01146a
29. [29]
  Y. Wang, B. Wang, K. Li, et al., Mater. Today Adv. 15 (2022) 100276. doi: 10.1016/j.mtadv.2022.100276
30. [30]
  K. Trabelsi, R. Ciriminna, Y. Albo, et al., Chem. Open 9 (2020) 459–463. doi: 10.1002/open.202000016
31. [31]
  D. Zhu, Y. Su, M.L. Young, et al., ACS Appl. Mater. Interfaces 9 (2017) 27453–27461. doi: 10.1021/acsami.7b06654
32. [32]
  A.M. Alotaibi, B.A.D. Williamson, S. Sathasivam, et al., ACS Appl. Mater. Interfaces 12 (2020) 15348–15361. doi: 10.1021/acsami.9b22056
33. [33]
  X. He, S. Chen, X. Mao, RSC Adv. 12 (2022) 6540–6551. doi: 10.1039/d1ra08335j
34. [34]
  Y. Oh, C.B. Ahn, J.H. Hyung, et al., Toxicol. Appl. Pharm. 385 (2019) 114779. doi: 10.1016/j.taap.2019.114779
35. [35]
  Z. Shan, H. Zhang, C. He, et al., Int. J. Mol. Sci. 25 (2024) 8726. doi: 10.3390/ijms25168726
36. [36]
  M. Li, P. Wan, W. Wang, et al., Sci. Rep. 9 (2019) 933. doi: 10.1038/s41598-018-37091-8
37. [37]
  C. Xu, Z. Liu, X. Chen, et al., Chin. Chem. Lett. 35 (2024) 109197. doi: 10.1016/j.cclet.2023.109197
38. [38]
  J. Chen, C. Tu, X. Tang, et al., Stem Cell Res. Ther. 10 (2019) 379. doi: 10.1186/s13287-019-1464-x
39. [39]
  Y. Zhou, S. Han, L. Xiao, et al., J. Mater. Chem. B 6 (2018) 3274–3284. doi: 10.1039/c8tb00683k
40. [40]
  X. Wang, Y. Zhang, C. Han, Wound Rep. Reg. 22 (2014) 288–289. doi: 10.1111/wrr.12150
41. [41]
  Y. Yin, J. Guo, S. Zhang, et al., Chin. Chem. Lett. 36 (2025) 110771. doi: 10.1016/j.cclet.2024.110771
42. [42]
  S.N. Nayab, F.H. Jones, I. Olsen, Biomaterials 26 (2005) 4717–4727. doi: 10.1016/j.biomaterials.2004.11.044
43. [43]
  J.W. Park, K.B. Park, J.Y. Suh, Biomaterials 28 (2007) 3306–3313. doi: 10.1016/j.biomaterials.2007.04.007
44. [44]
  K. Liu, H. Zhang, M. Lu, et al., Appl. Surf. Sci. 478 (2019) 162–175. doi: 10.1016/j.apsusc.2019.01.219
45. [45]
  G. Yin, X. Yang, Z. Zhou, et al., Mater. Chem. Front. 2 (2018) 544–553. doi: 10.1039/c7qm00600d
46. [46]
  E. Zhang, H. Chen, F. Shen, J. Mater. Sci.: Mater. Med. 21 (2010) 2151–2163. doi: 10.1007/s10856-010-4070-0
47. [47]
  H. Yang, C. Liu, P. Wan, et al., APL Mater. 1 (2013) 052104. doi: 10.1063/1.4828935
48. [48]
  C. Shuai, S. Li, S. Peng, et al., Mater. Chem. Front. 3 (2019) 544–562. doi: 10.1039/c8qm00507a
49. [49]
  M. Mao, S. Zhu, L. Zhang, et al., ACS Appl. Mater. Interfaces 14 (2022) 43955–43964. doi: 10.1021/acsami.2c12513
50. [50]
  Y. Qin, A. Liu, H. Guo, et al., Acta Biomater. 145 (2022) 403–415. doi: 10.1016/j.actbio.2022.03.055
51. [51]
  Y. Lin, Y. Yang, Y. Zhao, et al., J. Mater. Sci.: Mater. Med. 32 (2021) 24. doi: 10.1007/s10856-021-06497-8
52. [52]
  I. Cacciotti, J. Mater. Sci. 52 (2017) 8812–8831. doi: 10.1007/s10853-017-1010-0
53. [53]
  K. Glenske, P. Donkiewicz, A. Kwitsch, et al., Int. J. Mol. Sci. 19 (2018) 826. doi: 10.3390/ijms19030826
54. [54]
  S. Basu, B.K. Banik, Curr. Organocatal. 11 (2024) 265–272. doi: 10.2174/0122133372285610231227094959
55. [55]
  F. Abushahba, E. Sderling, L.A. Setälä, et al., Biomed. Phys. Eng. 4 (2018) 045002. doi: 10.1088/2057-1976/aabeee
56. [56]
  S. Burtscher, P. Krieg, A. Killinger, et al., Materials 12 (2019) 3495. doi: 10.3390/ma12213495
57. [57]
  M.M. Babu, P.S. Prasad, S.H. Bindu, et al., J. Compos. Sci. 4 (2020) 129. doi: 10.1002/9781119679455.ch10
58. [58]
  M. Khodaei, F. Nejatidanesh, M.J. Shirani, et al., J. Mech. Behav. Biomed. 100 (2019) 103396. doi: 10.1016/j.jmbbm.2019.103396
59. [59]
  Y. Yang, C. Lu, S. Peng, et al., Virtual Phys. Prototyp. 15 (2020) 278–293. doi: 10.1080/17452759.2020.1748381
60. [60]
  R.K. Samudrala, P.A. Azeem, J. Alloys Compd. 810 (2019) 151853. doi: 10.1016/j.jallcom.2019.151853
61. [61]
  A.M.F. Alhalawani, C. Mehrvar, W. Stone, et al., Mater. Sci. Eng. C 71 (2017) 401–411. doi: 10.1016/j.msec.2016.10.024
62. [62]
  M.M. Babu, P.V. Rao, N. Veeraiah, et al., Colloids Surf. B 185 (2020) 110591. doi: 10.1016/j.colsurfb.2019.110591
63. [63]
  L. Souza, J.H. Lopes, D. Encarnação, et al., Sci. Rep. 8 (2018) 12808. doi: 10.1038/s41598-018-31114-0
64. [64]
  S. Prasad, V.K. Vyas, P.K. Harijan, et al., J. Aust. Ceram. Soc. 54 (2018) 411–421. doi: 10.1007/s41779-017-0167-y
65. [65]
  M. Furuya, J. Kikuta, S. Fujimori, et al., Nat. Commun. 9 (2018) 300. doi: 10.1038/s41467-017-02541-w
66. [66]
  J. Hao, X. Yu, K. Tang, et al., Acta Biomater. 184 (2024) 431–443. doi: 10.1016/j.actbio.2024.06.016
67. [67]
  Y.B. Elalmis, B.K. Ikizler, S.K. Depren, et al., Int. J. Appl. Glass. Sci. 12 (2021) 313–327. doi: 10.1111/ijag.16043
68. [68]
  J. Pawlik, M. Widziołek, K.C. Kowalska, et al., J. Biomed. Mater. Res. A 102 (2014) 2383–2394. doi: 10.1002/jbm.a.34903
69. [69]
  F.H. Laybidi, A. Bahrami, Mater. Lett. 365 (2024) 136433. doi: 10.1016/j.matlet.2024.136433
70. [70]
  J. Feng, J. Liu, Y. Wang, et al., J. Mater. Sci.: Mater. Med. 34 (2023) 36. doi: 10.26599/phys.2023.9320507
71. [71]
  J. Shen, B. Chen, X. Zhai, et al., Bioact. Mater. 6 (2021) 503–519.
72. [72]
  S. Xu, K. Lin, Z. Wang, et al., Biomaterials 29 (2008) 2588–2596. doi: 10.1016/j.biomaterials.2008.03.013
73. [73]
  H. Zhu, D. Zhai, C. Lin, et al., J. Mater. Chem. B 4 (2016) 6200–6212. doi: 10.1039/C6TB01692H
74. [74]
  C. Deng, Q. Yao, C. Feng, et al., Adv. Funct. Mater. 27 (2017) 1703117. doi: 10.1002/adfm.201703117
75. [75]
  A.R. Unnithan, A.R.K. Sasikala, P. Murugesan, et al., Int. J. Biol. Macromol. 77 (2015) 1–8.
76. [76]
  M. Radmansouri, E. Bahmani, E. Sarikhani, et al., Int. J. Biol. Macromol. 116 (2018) 378–384. doi: 10.1016/j.ijbiomac.2018.04.161
77. [77]
  A.K. Nayak, M. Maity, H. Barik, et al., J. Drug Deliv. Sci. Tec. 95 (2024) 105524. doi: 10.1016/j.jddst.2024.105524
78. [78]
  N. Wang, J.Y.H. Fuh, S.T. Dheen, et al., J. Biomed. Mater. Res. B 109 (2021) 160–179. doi: 10.1002/jbm.b.34688
79. [79]
  H. Tschernitschek, L. Borchers, W. Geurtsen, J. Prosthet. Dent. 96 (2006) 12. doi: 10.1016/j.prosdent.2006.02.020
80. [80]
  T. Liu, A. Hassan, M.Z.Y. Alrawas, et al., ACS Omega 9 (2024) 45652–45662. doi: 10.1021/acsomega.4c06268
81. [81]
  A. Hasan, M. Morshed, A. Memic, et al., Int. J. Nanomedcine 13 (2018) 5637–5655. doi: 10.2147/ijn.s153758
82. [82]
  Z. Xiang, K. Wang, W. Zhang, et al., J. Clust. Sci. 29 (2018) 1–7. doi: 10.1007/s10876-017-1311-0
83. [83]
  E. Fathi, R. Farahzadi, PLoS One 12 (2017) e0173877. doi: 10.1371/journal.pone.0173877
84. [84]
  D.N. Heo, W.K. Ko, H.R. Lee, et al., J. Colloid. Interf. Sci. 469 (2016) 129–137. doi: 10.1016/j.jcis.2016.02.022
85. [85]
  S.J. Amina, B. Guo, Int. J. Nanomedcine 15 (2020) 9823–9857. doi: 10.2147/ijn.s279094
86. [86]
  Y. Jia, B. Ma, X. Wei, et al., Chin. Chem. Lett. 28 (2017) 691–702. doi: 10.1016/j.cclet.2017.01.021
87. [87]
  H. Pangli, S. Vatanpour, S. Hortamani, et al., J. Burn Care Res. 42 (2021) 785–793. doi: 10.1093/jbcr/iraa205
88. [88]
  L. Xu, F. Pan, G. Yu, et al., Biomaterials 30 (2009) 1512–1523. doi: 10.1016/j.biomaterials.2008.12.001
89. [89]
  S. Prabhu, E.K. Poulose, Int. Nano Lett. 2 (2012) 32. doi: 10.1186/2228-5326-2-32
90. [90]
  K. Vadakkan, J. Hemapriya, A.K. Ngangbam, et al., Microb. Pathog. 196 (2024) 106933. doi: 10.1016/j.micpath.2024.106933
91. [91]
  P. Chairuangkitti, S. Lawanprasert, S. Roytrakul, et al., Toxicol. In Vitro 27 (2013) 330–338.
92. [92]
  S. Hackenberg, A. Scherzed, M. Kessler, et al., Toxicol. Lett. 201 (2011) 27–33. doi: 10.1016/j.toxlet.2010.12.001
93. [93]
  A. Gao, R. Hang, X. Huang, et al., Biomaterials 35 (2014) 4223–4235. doi: 10.1016/j.biomaterials.2014.01.058
94. [94]
  C. Sun, Y. Che, S. Lu, Biotechnol. Lett. 37 (2015) 467–473. doi: 10.1007/s10529-014-1698-8
95. [95]
  Z. Xiu, Q. Zhang, H.L. Puppala, et al., Nano Lett. 12 (2012) 4271–4275. doi: 10.1021/nl301934w
96. [96]
  S.K. Nandi, A. Shivaram, S. Bose, et al., J. Biomed. Mater. Res. B 106 (2018) 1073–1083. doi: 10.1002/jbm.b.33910
97. [97]
  P.A. Prashanth, R.S. Raveendra, R.H. Krishna, et al., J. Asian Ceram. Soc. 3 (2015) 345–351. doi: 10.1016/j.jascer.2015.07.001
98. [98]
  I.M. Sadiq, B. Chowdhury, N. Chandrasekaran, et al., Nanomedicine 5 (2009) 282–286. doi: 10.1016/j.nano.2009.01.002
99. [99]
  B. Yu, S. Fu, Z. Kang, et al., Ceram. Int. 46 (2020) 7783–7791. doi: 10.1016/j.ceramint.2019.11.282
100. [100]
  H.A. Derazkola, A. Simchi, J. Mech. Behav. Biomed. 79 (2018) 246–253. doi: 10.1016/j.jmbbm.2018.01.007
101. [101]
  S. Farjaminejad, R. Farjaminejad, F.G. Godoy, J. Funct. Biomater. 15 (2024) 241. doi: 10.3390/jfb15090241
102. [102]
  M. Hashimoto, S. Imazato, Dent. Mater. 31 (2015) 556–564. doi: 10.1016/j.dental.2015.02.009
103. [103]
  D.J. Nogueira, M. Arl, J.S. Köerich, et al., Toxicol. In Vitro 61 (2019) 104596.
104. [104]
  Q. Zhang, H. Wang, C. Ge, et al., J. Appl. Toxicol. 37 (2017) 1053–1064. doi: 10.1002/jat.3456
105. [105]
  R.E. Keihan, E.B. Noruzi, K.K. Chenab, et al., J. Tissue Eng. Regen. Med. 14 (2020) 1687–1714. doi: 10.1002/term.3131
106. [106]
  E. Tomaszewska, S. Muszyński, K. Ognik, et al., J. Trace. Elem. Med. Biol. 42 (2017) 103–110. doi: 10.1016/j.jtemb.2017.05.002
107. [107]
  S. Sahmani, M. Shahali, M.G. Nejad, et al., Eur. Phys. J. Plus. 134 (2019) 7. doi: 10.1140/epjp/i2019-12375-x
108. [108]
  E. Tabesh, H.R. Salimijazi, M. Kharaziha, et al., Surf. Coat. Tech. 364 (2019) 239–247. doi: 10.1016/j.surfcoat.2019.02.040
109. [109]
  I.A.J. van Hengel, M.W.A.M. Tierolf, V.P.M. Valerio, et al., J. Mater. Chem. B 8 (2020) 1589–1602. doi: 10.1039/c9tb02434d
110. [110]
  N. Iqbal, M.R.A. Kadir, N.H. Mahmood, et al., Ceram. Int. 40 (2014) 4507–4513. doi: 10.1016/j.ceramint.2013.08.125
111. [111]
  G. Jin, H. Qin, H. Cao, et al., Biomaterials 35 (2014) 7699–7713. doi: 10.1016/j.biomaterials.2014.05.074
112. [112]
  B. Bageshlooyafshar, S. Vakilian, M. Kehtari, et al., Res. Vet. Sci. 124 (2019) 444–451. doi: 10.1016/j.rvsc.2017.09.015
113. [113]
  Q. Zhang, K. Huang, J. Tan, et al., Chin. Chem. Lett. 33 (2022) 1623–1626. doi: 10.1016/j.cclet.2021.09.105
114. [114]
  H. Hu, W. Zhang, Y. Qiao, et al., Acta Biomater. 8 (2012) 904–915. doi: 10.1016/j.actbio.2011.09.031
115. [115]
  R. Wang, X. He, Y. Gao, et al., Mater. Sci. Eng. C 75 (2017) 7–15. doi: 10.1016/j.msec.2017.02.036
116. [116]
  V. Kononenko, N. Repar, N. Marui, et al., Toxicol. In Vitro 40 (2017) 256–263.
117. [117]
  H. Bahadar, F. Maqbool, K. Niaz, et al., Iran. Biomed. J. 20 (2016) 1.
118. [118]
  M.T. Tsai, Y. Chang, H. Huang, et al., Thin Solid Films 528 (2013) 143–150. doi: 10.1016/j.tsf.2012.05.093
119. [119]
  J. Walker, S. Shadanbaz, T.B.F. Woodfield, et al., J. Biomed. Mater. Res. B 102 (2014) 1316–1331. doi: 10.1002/jbm.b.33113
120. [120]
  M.M. Belluci, G. Giro, R.A.L.D. Barrio, et al., Clin. Oral Implan. Res. 22 (2011) 716–721. doi: 10.1111/j.1600-0501.2010.02046.x
121. [121]
  J. Fischer, D. Pröfrock, N. Hort, et al., Mater. Sci. Eng. B 176 (2011) 830–834. doi: 10.1016/j.mseb.2011.04.008
122. [122]
  M.L. Dittler, I. Unalan, A. Grünewald, et al., Colloids Surf. B 182 (2019) 110346. doi: 10.1016/j.colsurfb.2019.110346
123. [123]
  M. Ghobadian, M. Nabiuni, K. Parivar, et al., Ecotox. Environ. Safe. 122 (2015) 260–267. doi: 10.1016/j.ecoenv.2015.08.009
124. [124]
  Q.L. Loh, C. Choong, Tissue Eng. Part. B: Rev. 19 (2013) 485–502. doi: 10.1089/ten.teb.2012.0437
125. [125]
  F. Wang, H. Yao, X. Wu, et al., Chin. Chem. Lett. 35 (2024) 108821. doi: 10.1016/j.cclet.2023.108821
126. [126]
  Y. Liu, H. Wang, S. Qu, Chin. Chem. Lett. 36 (2025) 110618. doi: 10.1016/j.cclet.2024.110618
127. [127]
  G.R. Patzke, F. Krumeich, R. Nesper, Angew. Chem. Int. Ed. 41 (2002) 2446–2461. doi: 10.1002/1521-3773(20020715)41:14<2446::AID-ANIE2446>3.0.CO;2-K
128. [128]
  H. Zhang, S. Yang, N. Masako, et al., RSC Adv. 5 (2015) 38117–38124. doi: 10.1039/C4RA16803H
129. [129]
  H. Zhang, L.F. Cooper, X. Zhang, et al., RSC Adv. 6 (2016) 44062–44069. doi: 10.1039/C6RA04002K
130. [130]
  Y. Huang, X. Shen, H. Qiao, et al., Int. J. Nanomedcine 13 (2018) 633–640. doi: 10.2147/ijn.s147969
131. [131]
  W. Song, C. Yang, D.Q.S. Le, et al., ACS Appl. Mater. Interfaces 10 (2018) 7756–7764. doi: 10.1021/acsami.7b18289
132. [132]
  R. Zhao, X. Meng, Z. Pan, et al., Regen. Biomater. 12 (2025) 129. doi: 10.1093/rb/rbae129
133. [133]
  G. Mani, D. Porter, K. Grove, et al., J. Biomed. Mater. Res. A 110 (2022) 1291–1306. doi: 10.1002/jbm.a.37373
134. [134]
  N. Wang, H. Li, J. Wang, et al., ACS Appl. Mater. Interfaces 4 (2012) 4516–4523. doi: 10.1021/am300727v
135. [135]
  S. Wu, X. Shen, M. Chen, et al., Mater. Sci. Eng. C 120 (2021) 111777. doi: 10.1016/j.msec.2020.111777
136. [136]
  A.A. Balhaddad, I.M. Garcia, L. Mokeem, et al., Bioengineering 8 (2021) 146. doi: 10.3390/bioengineering8100146
137. [137]
  J. Li, Y. Zheng, Z. Yu, et al., Heliyon 10 (2024) e23779. doi: 10.1016/j.heliyon.2023.e23779
138. [138]
  D. Ziental, B.C. Goslinska, D.T. Mlynarczyk, et al., Nanomaterials 10 (2020) 387. doi: 10.3390/nano10020387
139. [139]
  M. Ge, Z. Zhou, H. Zhu, et al., Chin. Chem. Lett. 36 (2025) 110121. doi: 10.1016/j.cclet.2024.110121
140. [140]
  Y. Yan, Y. Wei, R. Yang, et al., Colloids Surf. B 179 (2019) 309–316. doi: 10.1016/j.colsurfb.2019.04.013
141. [141]
  M. Cheng, Y. Qiao, Q. Wang, et al., ACS Appl. Mater. Interfaces 7 (2015) 13053–13061. doi: 10.1021/acsami.5b03209
142. [142]
  C. Pan, T. Liu, Y. Yang, et al., Mater. Des. 196 (2020) 109086. doi: 10.1016/j.matdes.2020.109086
143. [143]
  X. Wang, X. Xi, G. Huo, et al., J. Energy. Chem. 53 (2021) 49–55. doi: 10.1117/12.2577739
144. [144]
  L. Zou, C. Hou, Z. Liu, et al., J. Am. Chem. Soc. 140 (2018) 15393–15401. doi: 10.1021/jacs.8b09092
145. [145]
  H. Qiao, C. Zhang, X. Dang, et al., Ceram. Int. 45 (2019) 22183–22195. doi: 10.1016/j.ceramint.2019.07.240
146. [146]
  A. Escobar, N. Muzzio, P.C. Angelomé, et al., Adv. Eng. Mater. 21 (2019) 1801210. doi: 10.1002/adem.201801210
147. [147]
  X. Zhang, X. Zhang, B. Wang, et al., Ceram. Int. 46 (2020) 13969–13979. doi: 10.1016/j.ceramint.2020.02.195
148. [148]
  I. Carvalho, L. Rodrigues, M.J. Lima, et al., Processes 9 (2021) 1428. doi: 10.3390/pr9081428
149. [149]
  S. Zhang, X. Pei, H. Gao, et al., Chin. Chem. Lett. 31 (2020) 1060–1070. doi: 10.1016/j.cclet.2019.11.036
150. [150]
  M.A. Fardjahromi, H. Nazari, S.M.A. Tafti, et al., Mater. Today Chem. 23 (2022) 100670. doi: 10.1016/j.mtchem.2021.100670
151. [151]
  C. Liu, Y. Wang, Y. Bao, et al., Chin. Chem. Lett. 36 (2025) 110652. doi: 10.1016/j.cclet.2024.110652
152. [152]
  G. Lu, S. Li, Z. Guo, et al., Nat. Chem. 4 (2012) 310–316. doi: 10.1038/nchem.1272
153. [153]
  J. Liu, Y. Tan, E. Shen, et al., Biomed. Mater. 17 (2022) 065026. doi: 10.1088/1748-605x/aca24c
154. [154]
  S. Rojas, F.J. Carmona, C.R. Maldonado, et al., Inorg. Chem. 55 (2016) 2650–2663. doi: 10.1021/acs.inorgchem.6b00045
155. [155]
  A. Wawrzyniak, K. Balawender, Animals 12 (2022) 1946. doi: 10.3390/ani12151946
156. [156]
  A. Bagherifard, A. Hosseinzadeh, F. Koosha, et al., Osteoporosis Int. 34 (2023) 1677–1701. doi: 10.1007/s00198-023-06836-1
1. [1]
  Dechao Yuan , Tianying Luo , Qiao Su , Changxing Qu , Meng Pan , Jia Xu , Mingyi Zhang , Yuanchao Luo , Renjian He , Shiwei Liu , Xiang Fang , Hong Duan , Zhiyong Qian . Nanozyme-based catalytic therapeutics: Applications in infectious diseases, cancer therapy, and bone regeneration. Chinese Chemical Letters, 2026, 37(3): 111842-. doi: 10.1016/j.cclet.2025.111842
2. [2]
  Xu Luo , Jinwen Xiao , Qiming Yang , Xiaolong Lu , Qianjun Huang , Xiaojun Ai , Bo Li , Li Sun , Long Chen . Biomaterials for surgical repair of osteoporotic bone defects. Chinese Chemical Letters, 2025, 36(1): 109684-. doi: 10.1016/j.cclet.2024.109684
3. [3]
  Feifei Wang , Hang Yao , Xinyue Wu , Yijian Tang , Yang Bai , Hui Chong , Huan Pang . Metal–organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases. Chinese Chemical Letters, 2024, 35(5): 108821-. doi: 10.1016/j.cclet.2023.108821
4. [4]
  Jing Guo , Zhi-Guo Lu , Rui-Chen Zhao , Bao-Ku Li , Xin Zhang . Nucleic acid therapy for metabolic-related diseases. Chinese Chemical Letters, 2025, 36(3): 109875-. doi: 10.1016/j.cclet.2024.109875
5. [5]
  Dayang Xie , Qiannan Cao , Huapan Fang , Yanhui Li , Huayu Tian . Applications and challenges of biomedical polymer materials in pulmonary diseases. Chinese Chemical Letters, 2026, 37(2): 111032-. doi: 10.1016/j.cclet.2025.111032
6. [6]
  Xin Zhang , Junyu Chen , Xiang Pei , Linxin Yang , Liang Wang , Luona Chen , Guangmei Yang , Xibo Pei , Qianbing Wan , Jian Wang . Drug-loading ZIF-8 for modification of microporous bone scaffold to promote vascularized bone regeneration. Chinese Chemical Letters, 2024, 35(6): 108889-. doi: 10.1016/j.cclet.2023.108889
7. [7]
  Lian Jin , Juan Zhang , Libo Nie , Yan Deng , Ghulam Jilany Khana , Nongyue He . Chitosan nanoparticles act as promising carriers of microRNAs to brain cells in neurodegenerative diseases. Chinese Chemical Letters, 2025, 36(10): 110774-. doi: 10.1016/j.cclet.2024.110774
8. [8]
  Jingwen Wang , Peizhang Zhao , Mengmeng Li , Jun Li , Yunfeng Lin . Remedying infectious bone defects via 3D printing technology. Chinese Chemical Letters, 2025, 36(9): 110686-. doi: 10.1016/j.cclet.2024.110686
9. [9]
  Tianxu Zhang , Dexuan Xiao , Mi Zhou , Yunfeng Lin , Tao Zhang , Xiaoxiao Cai . Protective effect of osteogenic growth peptide functionalized tetrahedral DNA nanostructure on bone marrow and bone formation ability in chemotherapy-induced myelosuppressive mice. Chinese Chemical Letters, 2025, 36(8): 110594-. doi: 10.1016/j.cclet.2024.110594
10. [10]
  Yuge Zhang , Siqi Xu , Chenpeng Chen , Haiyu Xian , Qitao Wen , Yunfeng Lin , Tao Wang . Tetrahedral framework nucleic acids in the prevention and treatment of skin and mucosal diseases: Advances and prospects. Chinese Chemical Letters, 2026, 37(2): 111728-. doi: 10.1016/j.cclet.2025.111728
11. [11]
  Yanjing Li , Jiayin Li , Yuqi Chang , Yunfeng Lin , Lei Sui . Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell. Chinese Chemical Letters, 2024, 35(9): 109414-. doi: 10.1016/j.cclet.2023.109414
12. [12]
  Jielin Wang , Han Ye , Bozhuang Zhou , Zhen Pan , Yucai Li , Zhenyuan Wei , Bin Chai , Yizhou Gao , Xiaojian Ye , Jiangming Yu . Biomimetic nanofibrillar/hyaluronic acid hydrogels remodel the neuromodulatory microenvironment for enhanced bone regeneration. Chinese Chemical Letters, 2025, 36(5): 110133-. doi: 10.1016/j.cclet.2024.110133
13. [13]
  Ruijianghan Shi , Yujie Zhu , Weitong Lu , Yuhan Shao , Yang Chen , Mi Zhou , Yunfeng Lin , Sirong Shi . Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair. Chinese Chemical Letters, 2025, 36(5): 110241-. doi: 10.1016/j.cclet.2024.110241
14. [14]
  Yaxin Sun , Huiyu Li , Shiquan Guo , Congju Li . Metal-based cathode catalysts for electrocatalytic ORR in microbial fuel cells: A review. Chinese Chemical Letters, 2024, 35(5): 109418-. doi: 10.1016/j.cclet.2023.109418
15. [15]
  Yatian Deng , Dao Wang , Jinglan Cheng , Yunkun Zhao , Zongbao Li , Chunyan Zang , Jian Li , Lichao Jia . A new popular transition metal-based catalyst: SmMn₂O₅ mullite-type oxide. Chinese Chemical Letters, 2024, 35(8): 109141-. doi: 10.1016/j.cclet.2023.109141
16. [16]
  Zhilin Meng , Haiying Lu , Weijie Li . A low-temperature strategy enables atomic-level control in noble metal-based high-entropy catalysts. Chinese Journal of Structural Chemistry, 2026, 45(3): 100800-100800. doi: 10.1016/j.cjsc.2025.100800
17. [17]
  Xinhui Fang , Xinrui Wang , Bin Ding . Applications of luminescent metal-organic frameworks as pioneering biosensors for biological and chemical detection. Chinese Chemical Letters, 2025, 36(8): 110453-. doi: 10.1016/j.cclet.2024.110453
18. [18]
  Jia JI , Zhaoyang GUO , Wenni LEI , Jiawei ZHENG , Haorong QIN , Jiahong YAN , Yinling HOU , Xiaoyan XIN , Wenmin WANG . Two dinuclear Gd(Ⅲ)-based complexes constructed by a multidentate diacylhydrazone ligand: Crystal structure, magnetocaloric effect, and biological activity. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 761-772. doi: 10.11862/CJIC.20240344
19. [19]
  Qiaojia GUO , Junkai CAI , Chunying DUAN . Effects of anions on the structural regulation of Zn-salen-modified metal-organic cage. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2203-2211. doi: 10.11862/CJIC.20240209
20. [20]
  Yihao He , Ru Guo , Lu Yang , Ling Li , Tong Zhang , Bing Wang , Yongzhuo Huang . Phospholipid complex-based microemulsion for treating concurrence of primary sclerosing cholangitis and inflammatory bowel disease via gut-liver crosstalk. Chinese Chemical Letters, 2025, 36(10): 110778-. doi: 10.1016/j.cclet.2024.110778

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(131)
HTML views(11)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142