Citation: Bingbing Dong, Junmin Zhang, Xiang-Yu Ye, Xuan Huang, Yonggui Robin Chi. Catalytic construction of P-stereogenic center via phosphorus-centered nucleophilic substitution[J]. Chinese Chemical Letters, ;2025, 36(9): 111052. doi: 10.1016/j.cclet.2025.111052 shu

Catalytic construction of P-stereogenic center via phosphorus-centered nucleophilic substitution

Bingbing Dong ^a ,
Junmin Zhang ^a ,
Xiang-Yu Ye ^c ,
Xuan Huang ^{a, *,} ,
Yonggui Robin Chi ^{b, c, *,}

a.
International Joint Research Center for Molecular Science, College of Chemistry and Environmental Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
b.
State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
c.
School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University, Singapore 637371, Singapore

huangxuan8@163.com

robinchi@ntu.edu.sg

Received Date: 18 December 2024
Revised Date: 25 February 2025
Accepted Date: 6 March 2025
Available Online: 7 March 2025

Figures(6)

P-stereogenic compounds play pivotal roles in natural products, pharmaceuticals, bioactive molecules, and catalysts/ligands, making their synthesis a highly researched area. Current studies have predominantly concentrated on fully carbon-substituted P-stereogenic species, despite the fact that many therapeutically relevant compounds feature P-O, P-N, or P-S bonds. The catalytic and stereoselective nucleophilic substitution at the P-center is acknowledged as a highly efficient and straightforward approach for constructing high-value P-stereogenic compounds, offering significant potential for further development. This review provides an overview of advancements in the construction of P-stereogenic centers based on P-centered nucleophilic substitution, highlighting key challenges, breakthroughs, and future opportunities in the field.
- P-stereogenic compounds,
- P‑stereogenic ProTides,
- P-centered nucleophilic substitution,
- Dynamic kinetic transformation,
- Asymmetric catalysis
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沈阳化工大学材料科学与工程学院沈阳 110142