Citation: Xin Li, Fei Xiong, Xudong Cao, Wei Liu, Haobo Chen, Jiayu He, Weina Zhang, Longguang Tang, Wei Huang, Xikuang Yao. CD44-targeting and ZIF-8 gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death[J]. Chinese Chemical Letters, ;2026, 37(1): 110970. doi: 10.1016/j.cclet.2025.110970 shu

CD44-targeting and ZIF-8 gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death

Xin Li ^a ,
Fei Xiong ^b ,
Xudong Cao ^b ,
Wei Liu ^b ,
Haobo Chen ^b ,
Jiayu He ^b ,
Weina Zhang ^b ,
Longguang Tang ^{c, *,} ,
Wei Huang ^{b, d} ,
Xikuang Yao ^{b, *,}

a.
School of Pharmaceutical Science, Nanjing Tech University (NanjingTech), Nanjing 211816, China
b.
School of Flexible Electronics (Future Technologies) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China
c.
Gaozhou People's Hospital, Maoming 525200, China
d.
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE), Northwestern Polytechnical University (NPU), Xi'an 710072, China

tanglongguang@zju.edu.cn

iamxyao@njtech.edu.cn

Received Date: 5 December 2024
Revised Date: 17 February 2025
Accepted Date: 18 February 2025
Available Online: 19 February 2025

Figures(8)

The field of nanomedicine has been revolutionized by the concept of immunogenic cell death (ICD)-enhanced cancer therapy, which holds immense promise for the efficient treatment of cancer. However, precise delivery of ICD inducer is severely hindered by complex biological barriers. How to design and build intelligent nanoplatform for adaptive and dynamic cancer therapy remains a big challenge. Herein, this article presents the design and preparation of CD44-targeting and ZIF-8 gated gold nanocage (Au@ZH) for programmed delivery of the 1,2-diaminocyclohexane-Pt(Ⅱ) (DACHPt) as ICD inducer. After actively targeting the CD44 on the surface of 4T1 tumor cell, this Pt-Au@ZH can be effectively endocytosed by the 4T1 cell and release the DACHPt in tumor acidic environment, resulting in ICD effect and superior antitumor efficacy both in vitro and in vivo in the presence of mild 808 nm laser irradiation. By integration of internal and external stimuli intelligently, this programmed nanoplatform is poised to become a cornerstone in the pursuit of effective and targeted cancer therapy in the foreseeable future.
- Programmed drug release,
- ZIF-8-gated,
- Gold nanocage,
- Immunogenic cell death,
- Cancer therapy
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