Citation: Tingting Du, Siyu Lu, Zongnan Zhu, Mei Zhu, Yan Zhang, Jian Zhang, Jixiang Chen. Pyrazole derivatives: Recent advances in discovery and development of pesticides[J]. Chinese Chemical Letters, ;2025, 36(9): 110912. doi: 10.1016/j.cclet.2025.110912 shu

Pyrazole derivatives: Recent advances in discovery and development of pesticides

State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R & D of Fine Chemicals of Guizhou University, Guiyang 550025, China

jianzhang@gzu.edu.cn

18230826028@163.com

Received Date: 25 October 2024
Revised Date: 20 January 2025
Accepted Date: 3 February 2025
Available Online: 4 February 2025

Figures(22)

Pyrazole derivatives have made impressive achievements in the discovery of new pesticides, especially novel fungicides, insecticides, and herbicides. The pyrazole ring containing two adjacent nitrogen atoms is an important active fragment, which showed broad-spectrum and efficient biological activities. With the great interest and focus on pyrazoles, it is necessary to keep up-to-date with the latest research progress on pyrazole derivatives in the discovery of new pesticides. Based on this, we reviewed the progress and applications of pyrazole derivatives in the discovery of fungicides, antibacterial agents, insecticides, herbicides, antiviral agents, and nematicides in the past decade, summarized the fungicidal, antibacterial, insecticidal, herbicidal, antiviral, and nematicidal activities of pyrazoles, as well as the synthetic methods of the representative compounds. We also discussed the structure-activity relationship (SAR) and mechanism of action of the active compounds, aiming to provide new clues and ideas for the search of new pyrazole pesticides with high efficiency, low toxicity, and unique mechanism of action.
- Pyrazole,
- New pesticides,
- Biological activity,
- SAR,
- Mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142