Citation: Hefei Yang, Le-Cheng Wang, Xiao-Feng Wu. Sustainable carbonylative transformation of alkyl iodides to amides via crosslinking of EDA and XAT[J]. Chinese Chemical Letters, ;2025, 36(9): 110843. doi: 10.1016/j.cclet.2025.110843 shu

Sustainable carbonylative transformation of alkyl iodides to amides via crosslinking of EDA and XAT

Hefei Yang ^{a, b} ,
Le-Cheng Wang ^{a, b} ,
Xiao-Feng Wu ^{a, b, *,}

a.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
b.
Leibniz-Institut für Katalyse e.V., Rostock 18059, Germany

Xiao-Feng.Wu@catalysis.de

Received Date: 13 November 2024
Revised Date: 1 January 2025
Accepted Date: 10 January 2025
Available Online: 11 January 2025

Figures(6)

The amide moiety plays an important role as a powerful bioactive backbone, and as the synthetic chemistry community moves toward more sp³-rich scaffolds, alkyl halides have become the feedstock of choice for obtaining carbonylation products. With the development of photoredox catalysis, several aminocarbonylation systems for alkyl halides were developed which usually require transition metal catalysis. Considering the demands for green sustainable chemical synthesis, here we report a metal-free, exogenous catalyst-free aminocarbonylation reaction of alkyl iodides under atmospheric pressure of carbon monoxide. Through a combination of EDA and XAT strategies, the reaction occurs efficiently under only light irradiation at room temperature.
- Carbonylation,
- Amide,
- Metal-free,
- Phtotchemistry,
- Radical
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