Citation: Ruijing Zhang, Yangyuting Zhou, Song Gao, Jun-Long Zhang. Construction of near-infrared active nickel(Ⅱ) nanoplatform for treating wound bacterial infection[J]. Chinese Chemical Letters, ;2026, 37(5): 110829. doi: 10.1016/j.cclet.2025.110829 shu

Construction of near-infrared active nickel(Ⅱ) nanoplatform for treating wound bacterial infection

Ruijing Zhang ^{a, b} ,
Yangyuting Zhou ^{b, c} ,
Song Gao ^{a, b, d, *,} ,
Jun-Long Zhang ^{b, *,}

a.
The Institute of Spin Science and Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
b.
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
c.
College of Chemistry and Chemical Engineering, Shantou University, Shantou 515063, China
d.
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China

gaosong@scut.edu.cn

zhangjunlong@pku.edu.cn

Received Date: 31 October 2024
Revised Date: 26 December 2024
Accepted Date: 6 January 2025
Available Online: 6 January 2025

Figures(9)

The rise of antibiotic-resistant bacteria and the formation of biofilms are significant challenges in surgical practice, posing a serious threat to public health due to postoperative wound infections. A promising approach to tackle this issue is the combination of photothermal therapy (PTT) and chemodynamic therapy (CDT), which has shown remarkable effectiveness in treating both cancer and wound infections. In our study, we developed an innovative artificial nanoplatform called Ni-2@F127 by encapsulating Ni-2 in a biocompatible Pluronic. When exposed to 880 nm laser irradiation, Ni-2@F127 exhibited exceptional photothermal performance, achieving a photothermal conversion efficiency of 60.4%, along with significant photocatalytic capabilities. This platform activates a Fenton-like reaction that catalyzes hydrogen peroxide (H₂O₂), producing toxic hydroxyl radicals (^•OH) effectively. The synergistic effects of hyperthermia and ^•OH not only destroy tumor cells but also demonstrate powerful antimicrobial activity, significantly inhibiting the growth of Escherichia coli and Staphylococcus aureus (S. aureus) in vitro under near-infrared (NIR) irradiation. Importantly, in animal models, Ni-2@F127 effectively eliminates S. aureus from deep tissues in cases of subcutaneous abscesses and knife injuries, significantly accelerating abscess resolution and promoting wound healing. The compelling evidence suggests that Ni-based metal complexes could serve as transformative antibacterial agents in phototherapy, unlocking vast potential for their application in wound healing and the treatment of bacterial infections.
- Nickel nanoplatform,
- Bacterial infection,
- Antimicrobial phototherapy,
- Photothermal therapy,
- Photocatalysis
1. [1]
  C.K. Sen, G.M. Gordillo, S. Roy, et al., Wound Repair Regen. 17 (2009) 763–771. doi: 10.1111/j.1524-475X.2009.00543.x
2. [2]
  Y.P. Liang, J.H. He, B.L. Guo, ACS Nano 15 (2021) 12687–12722. doi: 10.1021/acsnano.1c04206
3. [3]
  I. Negut, V. Grumezescu, A.M. Grumezescu, Molecules 23 (2018) 2392. doi: 10.3390/molecules23092392
4. [4]
  S.G. Deeks, J. Overbaugh, A. Phillips, S. Buchbinder, Nat. Rev. Dis. Primers 1 (2015) 15035. doi: 10.1038/nrdp.2015.35
5. [5]
  K.E. Jones, N.G. Patel, M.A. Levy, et al., Nature 451 (2008) 990–993. doi: 10.1038/nature06536
6. [6]
  J.E. Cefalu, K.M. Barrier, A.H. Davis, Crit. Care Nurs. Clin. N. Am. 29 (2017) 81–96. doi: 10.1016/j.cnc.2016.09.009
7. [7]
  R.L. Rosa, H.K. Johansen, S. Molin, Antibiotics 11 (2022) 419. doi: 10.3390/antibiotics11030419
8. [8]
  C. Willyard, Nature 543 (2017) 15. doi: 10.1038/nature.2017.21550
9. [9]
  Q. Pang, Z. Jiang, K. Wu, R. Hou, Y. Zhu, Antibiotics 12 (2023) 351. doi: 10.3390/antibiotics12020351
10. [10]
  D.I. Andersson, D. Hughes, Nat. Rev. Microbiol. 8 (2010) 260–271. doi: 10.1038/nrmicro2319
11. [11]
  Y. Song, Q. Sun, J. Luo, et al., Nano-Micro Lett. 14 (2022) 83. doi: 10.1007/s40820-022-00826-4
12. [12]
  S. Hao, H. Han, Z. Yang, et al., Nano-Micro Lett. 14 (2022) 178. doi: 10.1007/s40820-022-00901-w
13. [13]
  C.J. Murray, K.S. Ikuta, F. Sharara, et al., Lancet 399 (2022) 629–655. doi: 10.1016/S0140-6736(21)02724-0
14. [14]
  X. Li, J.F. Lovell, J. Yoon, X. Chen, Nat. Rev. Clin. Oncol. 17 (2020) 657–674. doi: 10.1038/s41571-020-0410-2
15. [15]
  L. Gai, R. Zhang, X. Shi, et al., Chem. Sci. 14 (2023) 1434–1442. doi: 10.1039/d2sc06435a
16. [16]
  Y. Yao, G. Ran, C.L. Hou, et al., J. Am. Chem. Soc. 144 (2022) 7346–7356. doi: 10.1021/jacs.2c00710
17. [17]
  Y. Xiong, Y. Rao, J. Hu, Z. Luo, C. Chen, Adv. Mater. (2023) 2305140.
18. [18]
  Y. Chen, Y. Gao, Y. Chen, et al., J. Control. Release 10 (328) (2020) 251–262.
19. [19]
  V.N. Nguyen, Z. Zhao, B.Z. Tang, Chem. Soc. Rev. 51 (2022) 3324–3340. doi: 10.1039/d1cs00647a
20. [20]
  X. Li, J.F. Lovell, J. Yoon, X. Chen, Nat. Rev. Clin. Oncol. 17 (2020) 657–674. doi: 10.1038/s41571-020-0410-2
21. [21]
  K. Yang, S. Zhao, B. Li, et al., Coord. Chem. Rev. 454 (2022) 214330. doi: 10.1016/j.ccr.2021.214330
22. [22]
  P. Manivasagan, J. Kim, E.S. Jang, Coord. Chem. Rev. 470 (2022) 214701. doi: 10.1016/j.ccr.2022.214701
23. [23]
  M. Liu, D. He, T. Yang, et al., J. Nanobiotechnol. 16 (2018) 23. doi: 10.15302/j-sscae-2018.04.005
24. [24]
  S. Yougbaré, C. Mutalik, G. Okoro, et al., Int. J. Nanomed. 16 (2021) 5831–5867. doi: 10.2147/ijn.s328767
25. [25]
  S. Cai, Y. Hao, X. Wang, et al., Adv. Funct. Mater. (2024) 2413036.
26. [26]
  P. Manivasagan, T. Thambi, A. Joe, et al., Prog. Mater. Sci. 144 (2024) 101292. doi: 10.1016/j.pmatsci.2024.101292
27. [27]
  N. Guo, Y. Xia, Y. Duan, et al., Chin. Chem. Lett. 34 (2023) 107542. doi: 10.1016/j.cclet.2022.05.056
28. [28]
  K. Cheng, H. Wang, S. Sun, et al., Small 19 (2023) e2207868. doi: 10.1002/smll.202207868
29. [29]
  W. Sun, X. Luo, P. Li, et al., Chin. Chem. Lett. 35 (2024) 109522. doi: 10.1016/j.cclet.2024.109522
30. [30]
  X. Lin, J. Song, X. Chen, H. Yang, Angew. Chem. Int. Ed. 59 (2020) 14212–14233. doi: 10.1002/anie.201906823
31. [31]
  B. Ran, L. Ran, Z. Wang, et al., Chem. Rev. 123 (2023) 12371–12430. doi: 10.1021/acs.chemrev.3c00326
32. [32]
  N. Yang, C. Cao, X. Lv, et al., BMEMat 1 (2023) e12005. doi: 10.1002/bmm2.12005
33. [33]
  M. Kolarikova, B. Hosikova, H. Dilenko, et al., Med. Res. Rev. 43 (2023) 717–774. doi: 10.1002/med.21935
34. [34]
  Z. Gong, Z. Dai, Adv. Sci. 8 (2021) 2002178 (Weinh).
35. [35]
  R. Zhang, Q. Zeng, X. Li, D. Xing, T. Zhang, Biomaterials 275 (2021) 120993. doi: 10.1016/j.biomaterials.2021.120993
36. [36]
  G. Zhu, Q. Wang, S. Lu, Y. Niu, Med. Princ. Pract. 26 (2017) 301–308. doi: 10.1159/000475501
37. [37]
  J. Huang, Y. Zheng, H. Niu, et al., Adv. Healthc. Mater. 13 (2024) e2302328. doi: 10.1002/adhm.202302328
38. [38]
  D. Xian, J. Song, L. Yang, et al., Oxid. Med. Cell. Longev. 2019 (2019) 2304018.
39. [39]
  P. Zhao, H. Li, W. Bu, Angew. Chem. Int. Ed. 62 (2023) e202210415. doi: 10.1002/anie.202210415
40. [40]
  Z. Tang, Y. Liu, M. He, W. Bu, Angew. Chem. Int. Ed. 58 (2019) 946–956. doi: 10.1002/anie.201805664
41. [41]
  Y. Fan, S. Liu, Y. Yi, H. Rong, J. Zhang, ACS Nano 15 (2021) 2005–2037. doi: 10.1021/acsnano.0c06962
42. [42]
  X. Wang, C. Zhang, L. He, et al., J. Nanobiotechnol. 21 (2023) 446. doi: 10.1186/s12951-023-02212-7
43. [43]
  L. Song, K. Luo, C. Liu, et al., J. Mater. Chem. B 12 (2024) 4975–4987. doi: 10.1039/d4tb00121d
44. [44]
  P. Hu, Z. Jia, S. Zhao, et al., Adv. Healthc. Mater. 13 (2024) e2401551. doi: 10.1002/adhm.202401551
45. [45]
  X. He, Y. Lv, Y. Lin, et al., Adv. Mater. 36 (2024) e2400366. doi: 10.1002/adma.202400366
46. [46]
  R. Zhang, H. Xu, Y. Yao, et al., J. Am. Chem. Soc. 145 (2023) 23257–23274. doi: 10.1021/jacs.3c08181
47. [47]
  A. Uberoi, A.M. Vangi, E.A. Grice, Nat. Rev. Microbiol. 22 (2024) 507–521. doi: 10.1038/s41579-024-01035-z
1. [1]
  Mengyao Gao , Shan Sun , Hengwei Lin , Cheng Yang . A multifunctional carbon dot-based nanoplatform for antibacterial therapy: Integrating photodynamic, photothermal, and gas treatments. Chinese Chemical Letters, 2026, 37(2): 111055-. doi: 10.1016/j.cclet.2025.111055
2. [2]
  Zhong Du , Li-Jun Zhu , Jia-Bao Xiong , Yu-Xiang Gao , Ya-Qi Cui , Maierhaba Aili , Chen-Yang Chu , Chi Zhang , Gao-Fei Huang , Xue-Liang Zhang , Nuernisha Alifu , Biao Dong . Multifunctional FA-PDA@ICG-Bi₂Se₃ nanoplatform for targeted NIR and X-ray dual-modal imaging and photothermal therapy of cervical cancer. Chinese Chemical Letters, 2026, 37(4): 111488-. doi: 10.1016/j.cclet.2025.111488
3. [3]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
4. [4]
  Siyi Lin , Qingxue Xu , Xuguan Bai , Zhennan Tian , Lu Wang , Fuxin Han , Shigui Chen , Qiang Cai . Halogen-bonded organic frameworks (XOFs) based on [N···Br⁺···N] bonds for enhanced photothermal cancer therapy. Chinese Chemical Letters, 2026, 37(1): 111425-. doi: 10.1016/j.cclet.2025.111425
5. [5]
  Xiaoyan Liu , Cong Xu , Ruhe Zhang , Yilu Zheng , Hengyu Liu , Haolin Chen , Meng Zhao , Jun Wu , Dongjun Lin . Black phosphorus nanosheets-based platform for B-cell lymphoma chemo-photothermal therapy. Chinese Chemical Letters, 2026, 37(5): 111401-. doi: 10.1016/j.cclet.2025.111401
6. [6]
  Wei Zhou , Di He , Ning Liu , Ying Li , Wenzhao Han , Weiping Zhou , Siyu Zhang , Cong Yu . A PDI-based NIR-Ⅱ fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(11): 110854-. doi: 10.1016/j.cclet.2025.110854
7. [7]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
8. [8]
  Mingrui Zhang , Lingyu Jin , Yuda Zhu , Junfeng Kou , Bo Liu , Jing Chen , Xiaolin Zhong , Xianghua Wu , Junfeng Zhang , Wenxiu Ren . A near-infrared Ⅱ fluorescent dye based on oxanthracene: Real-time imaging of drug-induced acute liver injury and photothermal therapy for tumor. Chinese Chemical Letters, 2025, 36(10): 110772-. doi: 10.1016/j.cclet.2024.110772
9. [9]
  Yanyan Ma , Lizhen Xu , Muxin Xu , Jie Niu , Wei Xu , Weiying Lin . All in one: An in-situ activated tumor theranostic agent for NIR-Ⅱ fluorescence imaging guided surgical resection and photothermal therapy. Chinese Chemical Letters, 2025, 36(11): 110850-. doi: 10.1016/j.cclet.2025.110850
10. [10]
  Lei Li , Annan Liu , Gang Wei , Xingchen Li , Hao Liang , Maja D. Nešić , Ze Wang , Hui Guo , Quan Lin . Advanced nanosystem for target recognition and precise dual-mode imaging-guided photothermal therapy against triple-negative breast cancer. Chinese Chemical Letters, 2026, 37(2): 110961-. doi: 10.1016/j.cclet.2025.110961
11. [11]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
12. [12]
  Zhenjian Li , Xue Wu , Lingyun Li , Bingzhe Wang , Guichuan Xing , Yupeng Liu , Songnan Qu . Red and near-infrared emissive nitrogen-sulfur co-doped carbonized nanoparticles for red laser-induced synergistic photothermal and photodynamic tumor therapy. Chinese Chemical Letters, 2026, 37(5): 111501-. doi: 10.1016/j.cclet.2025.111501
13. [13]
  Zhen Shi , Wei Jin , Yuhang Sun , Xu Li , Liang Mao , Xiaoyan Cai , Zaizhu Lou . Interface charge separation in Cu2CoSnS4/ZnIn2S4 heterojunction for boosting photocatalytic hydrogen production. Chinese Journal of Structural Chemistry, 2023, 42(12): 100201-100201. doi: 10.1016/j.cjsc.2023.100201
14. [14]
  Qiang Zhang , Weiran Gong , Huinan Che , Bin Liu , Yanhui Ao . S doping induces to promoted spatial separation of charge carriers on carbon nitride for efficiently photocatalytic degradation of atrazine. Chinese Journal of Structural Chemistry, 2023, 42(12): 100205-100205. doi: 10.1016/j.cjsc.2023.100205
15. [15]
  Ziruo Zhou , Wenyu Guo , Tingyu Yang , Dandan Zheng , Yuanxing Fang , Xiahui Lin , Yidong Hou , Guigang Zhang , Sibo Wang . Defect and nanostructure engineering of polymeric carbon nitride for visible-light-driven CO2 reduction. Chinese Journal of Structural Chemistry, 2024, 43(3): 100245-100245. doi: 10.1016/j.cjsc.2024.100245
16. [16]
  Weixu Li , Yuexin Wang , Lin Li , Xinyi Huang , Mengdi Liu , Bo Gui , Xianjun Lang , Cheng Wang . Promoting energy transfer pathway in porphyrin-based sp2 carbon-conjugated covalent organic frameworks for selective photocatalytic oxidation of sulfide. Chinese Journal of Structural Chemistry, 2024, 43(7): 100299-100299. doi: 10.1016/j.cjsc.2024.100299
17. [17]
  Mengjun Zhao , Yuhao Guo , Na Li , Tingjiang Yan . Deciphering the structural evolution and real active ingredients of iron oxides in photocatalytic CO2 hydrogenation. Chinese Journal of Structural Chemistry, 2024, 43(8): 100348-100348. doi: 10.1016/j.cjsc.2024.100348
18. [18]
  Jiangqi Ning , Junhan Huang , Yuhang Liu , Yanlei Chen , Qing Niu , Qingqing Lin , Yajun He , Zheyuan Liu , Yan Yu , Liuyi Li . Alkyl-linked TiO2@COF heterostructure facilitating photocatalytic CO2 reduction by targeted electron transport. Chinese Journal of Structural Chemistry, 2024, 43(12): 100453-100453. doi: 10.1016/j.cjsc.2024.100453
19. [19]
  Jiaqi Ma , Lan Li , Yiming Zhang , Jinjie Qian , Xusheng Wang . Covalent organic frameworks: Synthesis, structures, characterizations and progress of photocatalytic reduction of CO2. Chinese Journal of Structural Chemistry, 2024, 43(12): 100466-100466. doi: 10.1016/j.cjsc.2024.100466
20. [20]
  Yanghanbin Zhang , Dongxiao Wen , Wei Sun , Jiahe Peng , Dezhong Yu , Xin Li , Yang Qu , Jizhou Jiang . State-of-the-art evolution of g-C3N4-based photocatalytic applications: A critical review. Chinese Journal of Structural Chemistry, 2024, 43(12): 100469-100469. doi: 10.1016/j.cjsc.2024.100469

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(9)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142