Citation: Ruijing Zhang, Yangyuting Zhou, Song Gao, Jun-Long Zhang. Construction of near-infrared active nickel(Ⅱ) nanoplatform for treating wound bacterial infection[J]. Chinese Chemical Letters, ;2026, 37(5): 110829. doi: 10.1016/j.cclet.2025.110829 shu

Construction of near-infrared active nickel(Ⅱ) nanoplatform for treating wound bacterial infection

Ruijing Zhang ^{a, b} ,
Yangyuting Zhou ^{b, c} ,
Song Gao ^{a, b, d, *,} ,
Jun-Long Zhang ^{b, *,}

a.
The Institute of Spin Science and Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, China
b.
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
c.
College of Chemistry and Chemical Engineering, Shantou University, Shantou 515063, China
d.
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China

gaosong@scut.edu.cn

zhangjunlong@pku.edu.cn

Received Date: 31 October 2024
Revised Date: 26 December 2024
Accepted Date: 6 January 2025
Available Online: 6 January 2025

Figures(9)

The rise of antibiotic-resistant bacteria and the formation of biofilms are significant challenges in surgical practice, posing a serious threat to public health due to postoperative wound infections. A promising approach to tackle this issue is the combination of photothermal therapy (PTT) and chemodynamic therapy (CDT), which has shown remarkable effectiveness in treating both cancer and wound infections. In our study, we developed an innovative artificial nanoplatform called Ni-2@F127 by encapsulating Ni-2 in a biocompatible Pluronic. When exposed to 880 nm laser irradiation, Ni-2@F127 exhibited exceptional photothermal performance, achieving a photothermal conversion efficiency of 60.4%, along with significant photocatalytic capabilities. This platform activates a Fenton-like reaction that catalyzes hydrogen peroxide (H₂O₂), producing toxic hydroxyl radicals (^•OH) effectively. The synergistic effects of hyperthermia and ^•OH not only destroy tumor cells but also demonstrate powerful antimicrobial activity, significantly inhibiting the growth of Escherichia coli and Staphylococcus aureus (S. aureus) in vitro under near-infrared (NIR) irradiation. Importantly, in animal models, Ni-2@F127 effectively eliminates S. aureus from deep tissues in cases of subcutaneous abscesses and knife injuries, significantly accelerating abscess resolution and promoting wound healing. The compelling evidence suggests that Ni-based metal complexes could serve as transformative antibacterial agents in phototherapy, unlocking vast potential for their application in wound healing and the treatment of bacterial infections.
- Nickel nanoplatform,
- Bacterial infection,
- Antimicrobial phototherapy,
- Photothermal therapy,
- Photocatalysis
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