Citation: Lintao Wu, Yujia Meng, Xumei Zheng, Yiqiao Bai, Chun Han, Zhijun Wang, Jie Yang, Xiaobi Jing, Yong Yao. Pillar[5]arene based prodrug as a GSH-responsive SO₂ nanogenerator for effective gas cancer therapy[J]. Chinese Chemical Letters, ;2025, 36(9): 110808. doi: 10.1016/j.cclet.2024.110808 shu

Pillar[5]arene based prodrug as a GSH-responsive SO₂ nanogenerator for effective gas cancer therapy

Lintao Wu ^a ,
Yujia Meng ^b ,
Xumei Zheng ^a ,
Yiqiao Bai ^b ,
Chun Han ^a ,
Zhijun Wang ^a ,
Jie Yang ^d ,
Xiaobi Jing ^{c, *,} ,
Yong Yao ^{b, *,}

a.
Department of Chemistry, Changzhi University, Changzhi 046011, China
b.
School of Chemistry and Chemical Engineering, Nantong City Key Laboratory of Life-Organic Chemistry, Nantong University, Nantong 226019, China
c.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225009, China
d.
College of Science, Nanjing Forestry University, Nanjing 210037, China

xbjing@yzu.edu.cn

yaoyong1986@ntu.edu.cn

Received Date: 30 September 2024
Revised Date: 16 December 2024
Accepted Date: 26 December 2024
Available Online: 27 December 2024

Figures(5)

Sulfur dioxide (SO₂), being one of the therapeutic gaseous molecules, has been widely utilized in cancer therapy because of its high therapeutic efficacy and biosafety. Nevertheless, the in situ-triggered and efficient transportation of SO₂ to tumors are the main obstacles that restrict its clinical application. To overcome this impediment, we functionalized pillar[5]arene with 2, 4-dinitrobenzene sulfonic acid (DNSB) and then self-assembled it with tetraphenyl-PEG (TPE-PEG) in aqueous media to form fluorescent nanoparticles (PSTPE NPs). Meanwhile, the target guest (NH₂-PEG-FA) was encapsulated within the spacious cavity of pillar[5]arene via host-guest interaction. The resulting nanoparticles possess distinctive characteristics: (Ⅰ) dual GSH recognition motifs for enhanced SO₂ release kinetics; (Ⅱ) incorporation of targeting ligands for selective cytotoxicity towards tumor cells while sparing normal tissues and cells; and (Ⅲ) surface modification of pillar[5]arene with TPE-PEG conferring excellent dispersibility, biocompatibility, and fluorescence properties in aqueous environments. Collectively, this novel nanoparticle represents an innovative approach that utilizes macrocyclics as SO₂ gas donors to induce cellular apoptosis and provides new insights into gas-based therapy.
- Pillar[5]arenes,
- Theranostics,
- GSH-responsiveness,
- Host-guest interaction,
- Gas therapy
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Pillar[5]arene based prodrug as a GSH-responsive SO2 nanogenerator for effective gas cancer therapy

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通讯作者: 陈斌, bchen63@163.com

Pillar[5]arene based prodrug as a GSH-responsive SO₂ nanogenerator for effective gas cancer therapy