Citation: Yue Pan, Jing Ren, Yifan Sun, Luying Lu, Jia Gao, Liping Chen, Shancheng Yan, Zhiyang Li. Harnessing chirality: A new dawn in inorganic nanomaterial synthesis and biomedical applications[J]. Chinese Chemical Letters, ;2026, 37(4): 110791. doi: 10.1016/j.cclet.2024.110791 shu

Harnessing chirality: A new dawn in inorganic nanomaterial synthesis and biomedical applications

Yue Pan ^a ,
Jing Ren ^a ,
Yifan Sun ^b ,
Luying Lu ^b ,
Jia Gao ^b ,
Liping Chen ^a ,
Shancheng Yan ^{a, *,} ,
Zhiyang Li ^{b, *,}

a.
School of Chemistry and Life Sciences, School of Integrated Circuit Science and Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China
b.
Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China

yansc@njupt.edu.cn

lizhiyangcn@qq.com

Received Date: 28 October 2024
Revised Date: 16 December 2024
Accepted Date: 20 December 2024
Available Online: 23 December 2024

Figures(16)

Chirality, a fundamental property of biological systems, is widely present at the molecular, cellular, and tissue levels. Current studies have shown that chiral inorganic nanomaterials, have good chiral optical activity as well as high enantioselectivity. When interacting with biological systems, the enantioselective behavior of chiral inorganic nanomaterials towards biomolecules can distinguish between different isomers of biomarkers, which, combined with the excellent optical activity of chiral inorganic nanomaterials, allows for the rapid and sensitive detection of biomarkers. Moreover, chiral inorganic nanomaterials exhibit stronger internalization and retention capabilities in cells, and by specifically targeting specific biomarkers can regulate cellular activity and catalyze related reactions, thereby achieving synergistic treatment of various diseases. In addition, chiral inorganic nanomaterials also have good biocompatibility and do not cause cell damage in living organisms. Moreover, chiral inorganic nanomaterials have programmable surfaces that can be tailored to suit specific biological functions. Due to the important role of chiral inorganic nanomaterials in the biomedical field, this paper summarizes and discusses the synthesis and biomedical applications of chiral inorganic nanomaterials. It further looks forward to its future development prospects to provide a reference for promoting relevant research on chiral inorganic nanomaterials in biomedical fields.
- Chiral inorganic nanomaterials,
- Enantioselectivity,
- Chiral optical properties,
- Biomarker detection,
- Disease therapy
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