Citation: Fadeng Yang, Pengli Zhang, Jianbo Liu, Chuan Wan, Jinming Sun, Chuan Dai, Zhihong Liu, Yuhao An, Yujie Wu, Yun Xing, Feng Yin, Yuxin Ye, Wei Han, Zigang Li. Self-assembly of a cyclo-pentapeptide with a novel frame structure[J]. Chinese Chemical Letters, ;2025, 36(9): 110785. doi: 10.1016/j.cclet.2024.110785 shu

Self-assembly of a cyclo-pentapeptide with a novel frame structure

Fadeng Yang ^{a, 1} ,
Pengli Zhang ^{a, 1} ,
Jianbo Liu ^{b, 1} ,
Chuan Wan ^{e, 1} ,
Jinming Sun ^a ,
Chuan Dai ^d ,
Zhihong Liu ^b ,
Yuhao An ^b ,
Yujie Wu ^f ,
Yun Xing ^a ,
Feng Yin ^{b, *,} ,
Yuxin Ye ^{b, *,} ,
Wei Han ^{a, c, h, *,} ,
Zigang Li ^{a, c, g, *,}

a.
State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China
b.
Pingshan translational medicine center, Shenzhen Bay Laboratory, Shenzhen 518055, China
c.
Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518132, China
d.
Department of Pharmacy, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China
e.
College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China
f.
Office of Core Facilities, Shenzhen Bay Laboratory, Shenzhen 518055, China
g.
Tianfu Jincheng Laboratory, Chengdu 610212, China
h.
Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Hong Kong SAR, China

yinfeng@szbl.ac.cn

yeyx@szbl.ac.cn

hanw_chem@hkbu.edu.hk

lizg@pkusz.edu.cn

Received Date: 5 October 2024
Revised Date: 5 December 2024
Accepted Date: 19 December 2024
Available Online: 24 December 2024

Figures(5)

Developing novel building blocks with predictable side-chain orientations and minimal intramolecular interactions is essential for peptide-based self-assembling materials. Traditional structures like α-helices and β-sheets rely on such interactions for stability, limiting control over exposed interacting moieties. Here, we reported a novel, frame-like peptide scaffold that maintains exceptional stability without intramolecular interactions. This structure exposes its backbone and orients side chains for hierarchical self-assembly into micron-scale cubes. By introducing mutations at specific sites, we controlled packing orientations, offering new options for tunable self-assembly. Our scaffold provides a versatile platform for designing advanced peptide materials, with applications in nanotechnology and biomaterials.
- Peptide based self-assembly,
- Cyclo-pentapeptide,
- Rigid frame-like structure,
- Hierarchical packing,
- Chiral center induced conformation
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沈阳化工大学材料科学与工程学院沈阳 110142