Citation: Chenkai Yang, Xiaoling Pan, Weiguang Zhao, Zhiwen Qiu, Lei He, Cong Wu, Ang Li, Zhengnan Huang, Yilin Yan, Shengzhou Li, Zhuofan Nan, Xiangqian Cao, Bing Shen, Wei Li. Intratumoral photo-controlled antigens burst release for synergistic immunotherapy by bio-membrane and organic membrane coated dual-functional nanoparticles[J]. Chinese Chemical Letters, ;2025, 36(9): 110740. doi: 10.1016/j.cclet.2024.110740 shu

Intratumoral photo-controlled antigens burst release for synergistic immunotherapy by bio-membrane and organic membrane coated dual-functional nanoparticles

Chenkai Yang ^{a, 1} ,
Xiaoling Pan ^{b, 1} ,
Weiguang Zhao ^{a, 1} ,
Zhiwen Qiu ^b ,
Lei He ^b ,
Cong Wu ^b ,
Ang Li ^b ,
Zhengnan Huang ^a ,
Yilin Yan ^a ,
Shengzhou Li ^c ,
Zhuofan Nan ^c ,
Xiangqian Cao ^{c, *,} ,
Bing Shen ^{a, c, *,} ,
Wei Li ^{b, *,}

a.
Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China
b.
Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University, Shanghai 200433, China
c.
Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China

cxqcaoxiangqian@163.com

urodrshenbing@shsmu.edu.cn

liwei_dds@163.com

Received Date: 7 August 2024
Revised Date: 5 December 2024
Accepted Date: 8 December 2024
Available Online: 9 December 2024

Figures(7)

The induction of antitumor immunity by tumor antigens released from cancer cells following regional photothermal therapy (PTT) alone may not be adequate for achieving complete tumor elimination. Combination therapy with immune adjuvants enhances antitumor immune responses, but faces challenges such as targeting deficiencies, systemic toxicity, and uncontrolled release behavior. Herein, we introduce a novel dual-functional hybrid membrane nanoparticle (HM-NP) incorporating gold nanorods (GNRs) and a thermally responsive polymer shell. HM-NP demonstrates exceptional homotypic targeting efficacy beneath the tumor cell membrane (TM), leading to substantial tumor accumulation. Upon in situ near-infrared (NIR) stimulation, GNRs within HM-NP generate heat, triggering the burst release of HM by facilitating the contraction and disintegration of the thermally responsive polymer shell. HM-NP exhibits excellent photothermal conversion efficiency under NIR irradiation, enabling effective destruction of primary tumors, release of tumor-associated antigens, and stimulation of potent anti- cancer immune. Simultaneously, the immune responses are strengthened by TM and Escherichia coli membrane (EM) through promoting the maturation of antigen presenting cells (APCs) and activating cytotoxic T lymphocytes (CTLs). Moreover, the use of polymer shells enables efficient cancer therapy with minimal host clearance and adverse effects. This photothermally triggered immunotherapy holds promise for precise and personalized treatment of tumors.
- Hybrid membrane,
- Photothermal synergistic immunotherapy,
- Tumor-targeting,
- Photo-controlled release,
- Gold nanorods,
- Thermo-responsive
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