Citation: Liping Yuan, Meng Pan, Hanzhi Deng, Tingyu Yang, Qingya Liu, Wen Chen, Xicheng Li, Jie Liu, Keqi Xu, Xinlong He, Zhiyong Qian. Enhanced hair follicle accumulation and androgenetic alopecia treatment of finasteride by topical nanoparticles hydrogel system[J]. Chinese Chemical Letters, ;2025, 36(9): 110723. doi: 10.1016/j.cclet.2024.110723 shu

Enhanced hair follicle accumulation and androgenetic alopecia treatment of finasteride by topical nanoparticles hydrogel system

Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

anderson-qian@163.com

Received Date: 22 October 2024
Revised Date: 1 December 2024
Accepted Date: 4 December 2024
Available Online: 10 December 2024

Figures(6)

The androgenetic alopecia (AGA) is the most prevalent clinical manifestation of hair loss, believed to be associated with excessive dihydrotestosterone (DHT) caused by type Ⅱ 5α-reductase (5αR2). The utilization of oral finasteride (FNS), which selectively inhibits 5αR2, is frequently constrained by its adverse effects. Topical FNS formulations can mitigate adverse effects but often exhibit limited dermal permeability. Nanocarriers show great potential in augmenting the cutaneous permeation of loaded FNS due to their inherent properties of selective accumulation within the hair follicles (HFs). In this study, hollow mesoporous silica nanoparticles (HMSN) with varying sizes were utilized as the nanocarriers for FNS, following mixing with the Carbopol hydrogel (F@H/Gel) for direct topical application. Specifically, the influence of size on the targeted delivery of FNS to HFs, and its enhanced therapeutic efficacy for the AGA mice model was evaluated. Results showed that the HMSN, with a diameter of approximately 300 nm, exhibited significant enhancement in FNS retention within skin and HFs, as well as remarkably accelerated hair regrowth on an AGA mouse model. In conclusion, this FNS topical formulation has proved to be a viable approach in offering a secure and efficient treatment modality for AGA.
- Finasteride,
- Hollow mesoporous silica nanoparticles,
- Hair follicles,
- Skin permeation,
- Androgenetic alopecia
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沈阳化工大学材料科学与工程学院沈阳 110142