Citation: Sha-Sha Meng, Xiao-Yi Fu, Hai-Yue Wei, Ming Xu, Zhi-Yuan Gu. Improving the separation ability of MOF-based stationary phases by increasing the thermodynamic differentiation of analytes[J]. Chinese Chemical Letters, ;2025, 36(9): 110720. doi: 10.1016/j.cclet.2024.110720 shu

Improving the separation ability of MOF-based stationary phases by increasing the thermodynamic differentiation of analytes

Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of New Power Batteries, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

mingxu@njnu.edu.cn

xhytibetan@xza.edu.cn

Received Date: 31 July 2024
Revised Date: 22 October 2024
Accepted Date: 3 December 2024
Available Online: 4 December 2024

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For chromatographic separation, the reasonable modulation of stationary phases is the key factor to achieve high separation performance. We proposed that developing MOF stationary phases through precisely modulating the thermodynamic interactions between MOFs and analytes is conducive to improving the separation resolution. MIL-125, MIL-125-NH₂, MIL-143-BTB, and MIL-143-TATB were developed as stationary phases with the careful modulation of organic ligands. MIL-125-NH₂ and MIL-143-TATB coated columns exhibited much better separation performance than their counterparts, MIL-125 and MIL-143-BTB, respectively. The investigation of the separation mechanism indicated that thermodynamic interaction, rather than kinetic diffusion, was responsible for the separation improvement. MIL-125-NH₂ and MIL-143-TATB provided stronger and distinguishable interactions with targets than corresponding MIL-125 and MIL-143-BTB, respectively, resulting in enhanced separation performance. This work demonstrates a guide to improving the separation performance of MOF stationary phases by increasing the thermodynamic interactions between MOFs and analytes.
- Metal-organic frameworks,
- Stationary phase,
- Gas chromatography,
- Separation,
- Thermodynamic interaction
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