Citation: Lulu He, Le Wang, Zhen He, Yiqian Yang, Cheng Heng Pang, Aiguo Wu, Bencan Tang, Juan Li. An imine-linked covalent organic framework with intrinsic photo-induced mitochondrial regulation for breast cancer therapy[J]. Chinese Chemical Letters, ;2025, 36(9): 110717. doi: 10.1016/j.cclet.2024.110717 shu

An imine-linked covalent organic framework with intrinsic photo-induced mitochondrial regulation for breast cancer therapy

Lulu He ^{a, b, c, d} ,
Le Wang ^{b, c} ,
Zhen He ^{b, c} ,
Yiqian Yang ^{b, c} ,
Cheng Heng Pang ^{a, *,} ,
Aiguo Wu ^{b, c, d, *,} ,
Bencan Tang ^{a, *,} ,
Juan Li ^{b, c, d, *,}

a.
Department of Chemical and Environment Engineering, The University of Nottingham Ningbo China, Ningbo 315100, China
b.
Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
c.
Ningbo Cixi Institute of Biomedical Engineering, Cixi 315300, China
d.
Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China

Chengheng.Pang@nottingham.edu.cn

aiguo@nimte.ac.cn

Bencan.Tang@nottingham.edu.cn

lij@nimte.ac.cn

Received Date: 12 August 2024
Revised Date: 27 November 2024
Accepted Date: 3 December 2024
Available Online: 9 December 2024

Figures(6)

Majority of photodynamic therapy (PDT) or photothermal therapy (PTT) is achieved by the integration of photosensitizers or photothermal agents into nanocarriers, which may bring risks due to uncertain leakage with serious nonspecific damage to normal tissues. Thus, we report an imine-linked nanoscale covalent organic framework (COF) with intrinsic photo-response ability, showing a high singlet oxygen generation ability by 660 nm irradiation, followed by the surface fabrication of polydopamine (PDA) that displays an excellent photothermal conversion performance under 808 nm irradiation. Furthermore, therapeutic agents with the modulation capacity of subcellular organelle such as mitochondria, shows more precision and effectiveness in cancer therapy. Herein, the obtained COF@PDA nanoplatform not only provides an excellent PDT/PTT-in-one therapeutic effect on inhibition of MCF-7 cancer cells, but also gives a prominent photo-induced mitochondrial regulation performance for enhanced treatment.
- Covalent organic framework,
- Mitochondrial regulation,
- Photodynamic therapy,
- Photothermal therapy,
- Breast cancer
1. [1]
  J. Hu, J. Hu, W. Wu, et al., Acta Biomater. 148 (2022) 206–217. doi: 10.1016/j.actbio.2022.06.012
2. [2]
  S. Chen, T. Sun, M. Zheng, Z. Xie, Adv. Funct. Mater. 30 (2020) 2004680. doi: 10.1002/adfm.202004680
3. [3]
  S. Gan, X. Tong, Y. Zhang, et al., Adv. Funct. Mater. 29 (2019) 1902757. doi: 10.1002/adfm.201902757
4. [4]
  L. Zhang, Q.C. Yang, S. Wang, et al., Adv. Mater. 34 (2021) e2108174.
5. [5]
  P. Gao, R. Wei, Y. Chen, et al., Biomaterials 297 (2023) 122109. doi: 10.1016/j.biomaterials.2023.122109
6. [6]
  Y. Qin, M. Huang, C. Huang, et al., Chin. Chem. Lett. 35 (2024) 109171. doi: 10.1016/j.cclet.2023.109171
7. [7]
  C. Huang, S. Zhou, C. Chen, et al., Small 18 (2022) e2205062. doi: 10.1002/smll.202205062
8. [8]
  Y. Zhou, S. Jing, S. Liu, J. Nanobiotechnol. 20 (2022) 188. doi: 10.54691/bcpssh.v18i.974
9. [9]
  H. Peng, F. Yao, J. Zhao, et al., Exploration 3 (2023) 20220115. doi: 10.1002/EXP.20220115
10. [10]
  X. Yu, M. Lyu, X. Ou, et al., Adv. Healthc. Mater. 12 (2023) e2202907. doi: 10.1002/adhm.202202907
11. [11]
  Z. Yu, X. Luo, C. Zhang, et al., Chin. Chem. Lett. 35 (2024) 109519. doi: 10.1016/j.cclet.2024.109519
12. [12]
  N. Singh, J. Kim, J. Kim, et al., Bioact. Mater. 21 (2023) 358–380.
13. [13]
  Y. Shi, J. Yang, F. Gao, Q. Zhang, ACS Nano 17 (2023) 1879–1905. doi: 10.1021/acsnano.2c11346
14. [14]
  A. Mal, H. Ding, M. Li, W. Li, C. Wang, ACS Appl. Nano Mater. 5 (2022) 13972–13984. doi: 10.1021/acsanm.2c01517
15. [15]
  L. Zhang, A. Song, Q.C. Yang, et al., Nat. Commun. 14 (2023) 5355. doi: 10.1038/s41467-023-41121-z
16. [16]
  S. Wang, Y. Pang, S. Hu, et al., Chem. Eng. J. 451 (2023) 138864. doi: 10.1016/j.cej.2022.138864
17. [17]
  L. Zhang, Y. Xiao, Q.C. Yang, et al., Adv. Funct. Mater. 32 (2022) 2201542. doi: 10.1002/adfm.202201542
18. [18]
  P. Dong, H. Lv, R. Luo, Z. Li, X. Wu, J. Lei, Chem. Eng. J. 461 (2023) 141817. doi: 10.1016/j.cej.2023.141817
19. [19]
  X.J. Dong, W.Y. Li, Q. Guan, Y.A. Li, Y.B. Dong, Chem. Commun. 58 (2022) 2387–2390. doi: 10.1039/d1cc06330h
20. [20]
  L. Chen, J. Zhang, K. Cai, et al., Sens. Actuators B: Chem. 350 (2022) 130861. doi: 10.1016/j.snb.2021.130861
21. [21]
  J. Chen, Y. Wang, Y. Yu, et al., Exploration 3 (2023) 20220144. doi: 10.1002/EXP.20220144
22. [22]
  P. Gao, R. Wei, X. Liu, et al., Chem. Commun. 57 (2021) 5646–5649. doi: 10.1039/d1cc00314c
23. [23]
  J. Feng, W.X. Ren, F. Kong, et al., Sci. China Mater. 65 (2021) 1122–1133.
24. [24]
  D. Ren, G.R. Williams, Y. Zhang, et al., ACS Appl. Bio Mater. 5 (2022) 123–133. doi: 10.1021/acsabm.1c00926
25. [25]
  C.L. Hu, L.H. Cai, S.N. Liu, et al., Chem. Commun. 55 (2019) 9164. doi: 10.1039/c9cc04668b
26. [26]
  Q. Guan, L.L. Zhou, Y.A. Li, et al., ACS Nano 13 (2019) 13304–13316. doi: 10.1021/acsnano.9b06467
27. [27]
  Y. Xiao, C. Ma, Z. Jin, et al., Chem. Eng. J. 421 (2021) 127837. doi: 10.1016/j.cej.2020.127837
28. [28]
  D. Xi, M. Xiao, J. Cao, et al., Adv. Mater. 32 (2020) 1907855. doi: 10.1002/adma.201907855
1. [1]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
2. [2]
  Peng Gao , Yuanyuan Chen , Qianlin He , Xue Liu , Echuan Tan , Zhiqiang Yu , Hui Wang . Highly efficient adoptive cell therapy of metastatic triple negative breast cancer with bioactive covalent organic framework-engineered macrophages. Chinese Chemical Letters, 2025, 36(8): 110585-. doi: 10.1016/j.cclet.2024.110585
3. [3]
  Yu Qin , Mingyang Huang , Chenlu Huang , Hannah L. Perry , Linhua Zhang , Dunwan Zhu . O₂-generating multifunctional polymeric micelles for highly efficient and selective photodynamic-photothermal therapy in melanoma. Chinese Chemical Letters, 2024, 35(7): 109171-. doi: 10.1016/j.cclet.2023.109171
4. [4]
  Yaojun Li , Yun Li , Shenglong Liao , Yang Li , Shouchun Yin . Revolutionizing cancer therapies with organic photovoltaic non-fullerene acceptors: A deep dive into molecular engineering for advanced phototheranostics. Chinese Chemical Letters, 2025, 36(8): 110832-. doi: 10.1016/j.cclet.2025.110832
5. [5]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
6. [6]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
7. [7]
  Haoran Hou , Siwen Wei , Yutong Shao , Yingnan Wu , Gaobo Hong , Jing An , Jiarui Tian , Jianjun Du , Fengling Song , Xiaojun Peng . A 690-nm-excitable type Ⅰ & Ⅱ photosensitizer based on biotinylation of verteporfin for photodynamic therapy of deep-seated orthotopic breast tumors. Chinese Chemical Letters, 2025, 36(6): 110315-. doi: 10.1016/j.cclet.2024.110315
8. [8]
  Yupeng Liu , Hui Wang , Songnan Qu . Review on near-infrared absorbing/emissive carbon dots: From preparation to multi-functional application. Chinese Chemical Letters, 2025, 36(5): 110618-. doi: 10.1016/j.cclet.2024.110618
9. [9]
  Yuyao Guan , Baoting Yu , Jun Ding , Tingting Sun , Zhigang Xie . BODIPY photosensitizers for antibacterial photodynamic therapy. Chinese Chemical Letters, 2025, 36(8): 110645-. doi: 10.1016/j.cclet.2024.110645
10. [10]
  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
11. [11]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
12. [12]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
13. [13]
  Yiling Li , Zekun Gao , Xiuxiu Yue , Minhuan Lan , Xiuli Zheng , Benhua Wang , Shuang Zhao , Xiangzhi Song . FRET-based two-photon benzo[a] phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109133-. doi: 10.1016/j.cclet.2023.109133
14. [14]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
15. [15]
  Wenkai Liu , Yanxian Hou , Weijian Liu , Ran Wang , Shan He , Xiang Xia , Chengyuan Lv , Hua Gu , Qichao Yao , Qingze Pan , Zehou Su , Danhong Zhou , Wen Sun , Jiangli Fan , Xiaojun Peng . Se-substituted pentamethine cyanine for anticancer photodynamic therapy mediated using the hot band absorption process. Chinese Chemical Letters, 2024, 35(12): 109631-. doi: 10.1016/j.cclet.2024.109631
16. [16]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
17. [17]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
18. [18]
  Di An , Mingdong She , Ziyang Zhang , Ting Zhang , Miaomiao Xu , Jinjun Shao , Qian Shen , Xuna Tang . Light-responsive nanomaterials for biofilm removal in root canal treatment. Chinese Chemical Letters, 2025, 36(2): 109841-. doi: 10.1016/j.cclet.2024.109841
19. [19]
  Qianyun Ye , Yuanyuan Liang , Yuhe Yuan , Xiaohuan Sun , Liqi Zhu , Xuan Wu , Jie Han , Rong Guo . pH-responsive chiral supramolecular cysteine-Zn²⁺-indocyanine green assemblies for triple-level chirality-specific anti-tumor efficacy. Chinese Chemical Letters, 2025, 36(5): 110432-. doi: 10.1016/j.cclet.2024.110432
20. [20]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(9)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142