Citation: Xicheng Li, Dong Mo, Shoushan Hu, Meng Pan, Meng Wang, Tingyu Yang, Changxing Qu, Yujia Wei, Jianan Li, Hanzhi Deng, Zhongwu Bei, Tianying Luo, Qingya Liu, Yun Yang, Jun Liu, Jun Wang, Zhiyong Qian. A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis[J]. Chinese Chemical Letters, ;2025, 36(9): 110674. doi: 10.1016/j.cclet.2024.110674 shu

A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis

Xicheng Li ^a ,
Dong Mo ^a ,
Shoushan Hu ^b ,
Meng Pan ^a ,
Meng Wang ^a ,
Tingyu Yang ^a ,
Changxing Qu ^b ,
Yujia Wei ^a ,
Jianan Li ^a ,
Hanzhi Deng ^a ,
Zhongwu Bei ^a ,
Tianying Luo ^a ,
Qingya Liu ^a ,
Yun Yang ^a ,
Jun Liu ^b ,
Jun Wang ^b ,
Zhiyong Qian ^{a, *,}

a.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
State Key Laboratory of Oral Diseases and National Center for Stomatology and National Clinical Research Center for Oral Diseases and Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

anderson-qian@163.com

Received Date: 3 August 2024
Revised Date: 15 November 2024
Accepted Date: 22 November 2024
Available Online: 23 November 2024

Figures(8)

Periodontitis is a chronic inflammatory disease caused by oral pathogens, and the osteogenic potential of human periodontal ligament stem cells (hPDLSCs) is severely impaired under the inflammatory environment. Current clinical periodontitis treatment strategies such as surgical interventions and antibiotic delivery still suffer from poor antibacterial efficacy, difficulty in ameliorating excessive inflammatory responses and slow periodontal tissue regeneration. Here, we have innovatively developed a non-surgical treatment strategy based on a functional composite hydrogel. A composite hydrogel system (Pt@ZIF-8/ALN-ac/Gel) containing bioactive zeolite imidazolate framework-8 (ZIF-8) integrated with platinum nanoparticles (Pt@ZIF-8) and alendronate acrylamide (ALN-ac) was constructed on the basis of gelatin methacryloyl (GelMA) to achieve enhanced antibacterial effect and reactive oxygen species (ROS) scavenging ability while promoting the osteogenic potential of hPDLSCs. We confirmed that Pt@ZIF-8/ALN-ac/Gel was able to continuously release Zn²⁺ and exerted an obvious antibacterial effect against Porphyromonas gingivalis. In vitro experiments proved that Pt@ZIF-8/ALN-ac/Gel had good biocompatibility, while efficiently featuring excellent reactive oxygen species (ROS) scavenging capacity, increasing alkaline phosphatase activity, and promoting extracellular matrix mineralization by hPDLSCs. In vivo, Pt@ZIF-8/ALN-ac/Gel significantly inhibited the alveolar bone deterioration and reduced osteoclast activation and inflammation, thereby promoting the regeneration of damaged tissues. These findings demonstrated superior therapeutic efficacy in the reported clinical periodontitis treatment, exhibiting great potential for application.
- ZIF-8,
- Reactive oxygen species,
- Hydrogel,
- Antibacterial,
- Alendronate,
- Periodontal regeneration
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沈阳化工大学材料科学与工程学院沈阳 110142