Citation: Yangyang Zhang, Lu Qiu, Houying Li, Wenli Cai, Ergang Liu, Hongtao Zhang, Bahtiyor Muhitdinov, Jianming Liang, Yongzhuo Huang. Biomimetically engineered plant-derived exosomes-like nanovesicles for rheumatoid arthritis therapy[J]. Chinese Chemical Letters, ;2025, 36(9): 110658. doi: 10.1016/j.cclet.2024.110658 shu

Biomimetically engineered plant-derived exosomes-like nanovesicles for rheumatoid arthritis therapy

Yangyang Zhang ^{a, b, 1} ,
Lu Qiu ^{a, b, 1} ,
Houying Li ^{a, b, 1} ,
Wenli Cai ^{a, b} ,
Ergang Liu ^{b, *,} ,
Hongtao Zhang ^c ,
Bahtiyor Muhitdinov ^d ,
Jianming Liang ^{a, *,} ,
Yongzhuo Huang ^{a, b, e, f, *,}

a.
Artemisinin Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510450, China
b.
Zhongshan Institute for Drug Discovery, SIMM, CAS, Zhongshan 528437, China
c.
Department of Orthopedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan 528400, China
d.
Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent 100125, Uzbekistan
e.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China
f.
NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Shanghai 201203, China

liuergang@zidd.ac.cn

liangjianming@gzucm.edu.cn

yzhuang@simm.ac.cn

Received Date: 16 July 2024
Revised Date: 13 November 2024
Accepted Date: 20 November 2024
Available Online: 20 November 2024

Figures(4)

Rheumatoid arthritis (RA) is a refractory autoimmune disease with limited treatment options. Plant-derived exosomes-like nanovesicles (PDENs) have emerged as a novel nanomedical approach, with the inherent bioactive compounds from their source plants. The roots of Morinda officinalis How. (MO), a Chinese herb, exhibit notable anti-inflammatory activities and hold promising therapeutic value. We engineered a joint-targeting delivery system (termed MOE@EM) by masking MO-derived exosomes-like nanovesicles (MOE) with erythrocyte membrane (EM). This biomimetic strategy, using EM camouflage, is intended to improve the in vivo fate of MOE. We investigated the antioxidative and anti-inflammatory activities, immunogenicity, drug accumulation in the joint, and therapeutic efficacy to ascertain its suitability for RA therapy. UV irradiation significantly increased the activities of catalase and peroxidase of MOE, and enhanced the anti-inflammatory effects via the Wnt/β-catenin pathway. Furthermore, MOE@EM markedly attenuated dendritic cell activation. MOE@EM exhibited joint-specific delivery, with substantial reduction in paw swelling, and favorable modulation of immune microenvironment.
- Rheumatoid arthritis,
- Morinda officinalis How.,
- Plant-derived exosome like-nanovesicles,
- UV irradiation,
- Erythrocyte membrane coating,
- Targeted delivery
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