Citation: Shangqian Zhang, Jiaxuan Li, Xuan Hu, Zelong Chen, Junliang Dong, Chenhao Hu, Shuang Chao, Yinghua Lv, Yuxin Pei, Zhichao Pei. H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis[J]. Chinese Chemical Letters, ;2025, 36(1): 110314. doi: 10.1016/j.cclet.2024.110314 shu

H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis

College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China

peiyx@nwafu.edu.cn

peizc@nwafu.edu.cn

Received Date: 4 May 2024
Revised Date: 29 July 2024
Accepted Date: 31 July 2024
Available Online: 2 August 2024

Figures(4)

Disulfidptosis, a novel mechanism of programmed cell death through the disruption of tumor metabolic symbiosis (TMS), has showed tremendous potential in cancer therapy. However, the efficacy of disulfidptosis is limited by poor permeability of drugs in solid tumors. Herein, hydrogen sulfide (H₂S) and near-infrared (NIR) light-driven nanomotors (denoted as HGPP) have been constructed to efficiently penetrate tumors and induce disulfidptosis. HGPP demonstrate glutathione (GSH)-responsive release of H₂S, which combined with NIR light-induced photothermal effect drive HGPP movement to facilitate deep tumor penetration. The released H₂S induces tumor acidosis and disrupts TMS, where disulfide accumulation following cell starvation leads to disulfidptosis. In addition, HGPP induce hepatoma specific cellular uptake and catalyze the conversion of glucose and oxygen to produce hydrogen peroxide (H₂O₂), leading to glucose starvation. Overall, this study has developed a multifunctional Janus nanomotor that provides a novel strategy for disulfidptosis-based solid tumor therapy.
- H₂S,
- NIR light,
- Nanomotors,
- Disulfidptosis,
- Tumor metabolic symbiosis
1. [1]
  K.G. De La Cruz-López, L.J. Castro-Muñoz, D.O. Reyes-Hernández, et al., Front. Oncol. 9 (2019) 1143. doi: 10.3389/fonc.2019.01143
2. [2]
  U. Martinez-Outschoorn, F. Sotgia, M.P. Lisanti, Semin. Oncol. 41 (2014) 195–216. doi: 10.1053/j.seminoncol.2014.03.002
3. [3]
  C.J. Halbrook, G. Thurston, S. Boyer, et al., Nat. Cancer 3 (2022) 1386–1403. doi: 10.1038/s43018-022-00463-1
4. [4]
  J.M. Curry, M. Tuluc, D. Whitaker-Menezes, et al., Cell Cycle 12 (2013) 1371–1384. doi: 10.4161/cc.24092
5. [5]
  M. Wan, Z. Liu, T. Li, et al., Angew. Chem. Int. Ed. 60 (2021) 16139–16148. doi: 10.1002/anie.202104304
6. [6]
  S. Hui, J.M. Ghergurovich, R.J. Morscher, et al., Nature 551 (2017) 115–118. doi: 10.1038/nature24057
7. [7]
  H. Xiong, X. Liu, Z. Xie, et al., Adv. Healthcare Mater. 11 (2022) 2102724. doi: 10.1002/adhm.202102724
8. [8]
  C. Corbet, E. Bastien, N. Draoui, et al., Nat. Commun. 9 (2018) 1208. doi: 10.1038/s41467-018-03525-0
9. [9]
  J. Wang, Z. Sun, S. Wang, et al., J. Am. Chem. Soc. 144 (2022) 19884–19895. doi: 10.1021/jacs.2c07669
10. [10]
  W. Wang, L. Zhang, Q. Deng, et al., Nano Today 42 (2022) 101331. doi: 10.1016/j.nantod.2021.101331
11. [11]
  M. Tang, J. Ni, Z. Yue, et al., Angew. Chem. Int. Ed. 63 (2024) e202315031. doi: 10.1002/anie.202315031
12. [12]
  J. Gao, H. Qin, F. Wang, et al., Nat. Commun. 14 (2023) 4867. doi: 10.1038/s41467-023-40474-9
13. [13]
  M. Pal, N. Somalwar, A. Singh, et al., Adv. Mater. 30 (2018) 1800429. doi: 10.1002/adma.201800429
14. [14]
  M. Hansen-Bruhn, B. Esteban-Fernández de Ávila, M. Beltrán-Gastélum, et al., Angew. Chem. Int. Ed. 57 (2018) 2657–2661. doi: 10.1002/anie.201713082
15. [15]
  S. Zhang, X. Liu, Y. Hao, et al., J. Colloid Interf. Sci. 650 (2023) 67–80. doi: 10.1007/s11401-023-0005-1
16. [16]
  M. Liu, L. Chen, Z. Zhao, et al., J. Am. Chem. Soc. 144 (2022) 3892–3901. doi: 10.1021/jacs.1c11749
17. [17]
  Y. Tu, F. Peng, D. Wilson, Adv. Mater. 29 (2017) 1701970. doi: 10.1002/adma.201701970
18. [18]
  M. Wan, T. Li, H. Chen, et al., Angew. Chem. Int. Ed. 60 (2021) 13158–13176. doi: 10.1002/anie.202013689
19. [19]
  R. Zhuang, D. Zhou, X. Chang, et al., Appl. Mater. Today 26 (2022) 101314. doi: 10.1016/j.apmt.2021.101314
20. [20]
  Q. Zhan, X. Shi, D. Fan, et al., Chem. Eng. J. 404 (2021) 126443. doi: 10.1016/j.cej.2020.126443
21. [21]
  X. Chang, Y. Feng, B. Guo, et al., Nanoscale 14 (2022) 219–238. doi: 10.1039/d1nr07172f
22. [22]
  J. Li, C.C. Mayorga-Martinez, C.D. Ohl, et al., Adv. Funct. Mater. 32 (2022) 2102265. doi: 10.1002/adfm.202102265
23. [23]
  S.B. Wang, C. Zhang, Z.J. Chen, et al., ACS Nano 13 (2019) 5523–5532. doi: 10.1021/acsnano.9b00345
24. [24]
  N. Li, C. Huang, J. Zhang, et al., ACS Nano 17 (2023) 12573–12593. doi: 10.1021/acsnano.3c02781
25. [25]
  F. Tong, J. Liu, Y. Zhong, et al., Appl. Mater. Today 32 (2023) 101823. doi: 10.1016/j.apmt.2023.101823
26. [26]
  H. Chen, T. Shi, Y. Wang, et al., J. Am. Chem. Soc. 143 (2021) 12025–12037. doi: 10.1021/jacs.1c03071
27. [27]
  Q. Fan, W. Xiong, H. Zhou, et al., Adv. Mater. 35 (2023) 2305932. doi: 10.1002/adma.202305932
28. [28]
  S.J. Dixon, K.M. Lemberg, M.R. Lamprecht, et al., Cell 149 (2012) 1060–1072. doi: 10.1016/j.cell.2012.03.042
29. [29]
  L. Qiao, G. Zhu, T. Jiang, et al., Adv. Mater. 36 (2024) 2308241. doi: 10.1002/adma.202308241
30. [30]
  F. Zhao, L. Liang, H. Wang, et al., Adv. Funct. Mater. 33 (2023) 2300941. doi: 10.1002/adfm.202300941
31. [31]
  X. Liu, L. Nie, Y. Zhang, et al., Nat. Cell Biol. 25 (2023) 404–414. doi: 10.1038/s41556-023-01091-2
32. [32]
  Y. Yan, H. Teng, Q. Hang, et al., Nat. Commun. 14 (2023) 3673. doi: 10.1038/s41467-023-39401-9
33. [33]
  L. Hou, X. Gong, J. Yang, et al., Adv. Mater. 34 (2022) 2200389. doi: 10.1002/adma.202200389
34. [34]
  L. Fu, Y. Wan, C. Qi, et al., Adv. Mater. 33 (2021) 2006892. doi: 10.1002/adma.202006892
35. [35]
  W. Tian, Y. Su, Y. Tian, et al., Adv. Sci. 4 (2017) 1600356. doi: 10.1002/advs.201600356
36. [36]
  W. Xu, J. Qian, G. Hou, et al., Adv. Funct. Mater. 32 (2022) 2205013. doi: 10.1002/adfm.202205013
37. [37]
  Z.W. Lee, X.Y. Teo, E.Y.W. Tay, et al., Br. J. Pharmacol. 171 (2014) 4322–4336. doi: 10.1111/bph.12773
38. [38]
  B. Liu, S. Liang, Z. Wang, et al., Adv. Mater. 33 (2021) 2101223. doi: 10.1002/adma.202101223
39. [39]
  J. Chen, F. Xue, W. Du, et al., Nano Lett. 22 (2022) 6156–6165. doi: 10.1021/acs.nanolett.2c01346
40. [40]
  B. Li, Q. Li, Z. Qi, et al., Angew. Chem. Int. Ed. 63 (2024) e202316323. doi: 10.1002/anie.202316323
41. [41]
  J. Liang, Y. Sun, K. Wang, et al., ACS Appl. Mater. Interfaces 15 (2023) 18191–18204. doi: 10.1021/acsami.2c22448
42. [42]
  D. Ren, L. Tang, Z. Wu, et al., Chin. Chem. Lett. 34 (2023) 108617. doi: 10.1016/j.cclet.2023.108617
43. [43]
  J. Yu, Y. Li, A. Yan, et al., Adv. Sci. 10 (2023) 2301919. doi: 10.1002/advs.202301919
44. [44]
  H. Liu, J. Zhang, Y. Jia, et al., Chem. Eng. J. 442 (2022) 135994. doi: 10.1016/j.cej.2022.135994
45. [45]
  Y. Kang, W. Sun, S. Li, et al., Adv. Sci. 6 (2019) 1900716. doi: 10.1002/advs.201900716
46. [46]
  S. Jeon, J. Clavadetscher, D.K. Lee, et al., Nanomaterials 8 (2018) 1028. doi: 10.3390/nano8121028
47. [47]
  S. Cao, Z. Pei, Y. Xu, et al., Chem. Mater. 28 (2016) 4501–4506. doi: 10.1021/acs.chemmater.6b01857
48. [48]
  Y. Qu, W. Jin, Y. Wan, et al., Chin. Chem. Lett. 35 (2024) 108493. doi: 10.1016/j.cclet.2023.108493
49. [49]
  H. Lu, M.H. Stenzel, Small 14 (2018) 1702858. doi: 10.1002/smll.201702858
50. [50]
  T. Sun, H. Wang, X. Zhang, et al., Small Struct. 5 (2023) 2300350.
51. [51]
  Z. Tang, S. Wu, P. Zhao, et al., Adv. Sci. 9 (2022) 2201232. doi: 10.1002/advs.202201232
52. [52]
  B. Xie, H. Zhao, Y.F. Ding, et al., Adv. Sci. 10 (2023) 2304407. doi: 10.1002/advs.202304407
53. [53]
  Z. Shen, N. Ma, F. Wang, et al., Chin. Chem. Lett. 33 (2022) 4563–4566. doi: 10.1016/j.cclet.2022.01.069
54. [54]
  J. Liu, W. Zhang, X. Wang, et al., J. Am. Chem. Soc. 36 (2023) 19662–19675. doi: 10.1021/jacs.3c04303
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4. [4]
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12. [12]
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

H2S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis

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通讯作者: 陈斌, bchen63@163.com

H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis