Citation: Haijun Shen, Yi Qiao, Chun Zhang, Yane Ma, Jialing Chen, Yingying Cao, Wenna Zheng. A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing[J]. Chinese Chemical Letters, ;2024, 35(12): 110283. doi: 10.1016/j.cclet.2024.110283 shu

A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing

Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang 212013, China

shenhj@ujs.edu.cn

Received Date: 13 May 2024
Revised Date: 15 July 2024
Accepted Date: 17 July 2024
Available Online: 18 July 2024

Figures(5)

Diabetic pressure ulcers (DPU) are non-healing due to vascular dysfunction and bacterial infection. Early intervention can delay ulcer progression, such as preventing the formation of full-thickness skin defects. Local administration of deferoxamine (DFO) at wound sites has been shown to promote neovascularization and enhance wound healing. However, since DPU skin wounds are not full-thickness defects and DFO is hydrophilic, enhancing its transdermal delivery is crucial for effective treatment. Photothermal ablation of stratum corneum, generated by copper sulfide nanoparticles (CuS NPs) under near-infrared (NIR) light irradiation, is a promising method to improve transdermal drug delivery. Meanwhile, CuS NPs-induced photothermal therapy offers excellent antibacterial performance. In this study, DFO and CuS NPs were incorporated into a matrix metalloproteinase (MMPs)-sensitive hydrogel. This hydrogel promotes cell adhesion and is degraded by cell-secreted MMPs, a process crucial for the controlled release of encapsulated DFO and CuS NPs. Under NIR irradiation, the stratum corneum is disrupted, facilitating transdermal DFO delivery and simultaneously eliminating infected bacteria. As a result, the essential requirements for DPU treatment, "facilitating transdermal DFO delivery, promoting angiogenesis, and inhibiting bacterial infection", were achieved simultaneously.
- Diabetic pressure ulcer,
- Transdermal drug delivery,
- Matrix metalloproteinase-sensitive hydrogel,
- Antibacterial,
- Angiogenesis
1. [1]
  N.H. Cho, J.E. Shaw, S. Karuranga, et al., Diabetes Res Clin Pract. 138 (2018) 271–281. doi: 10.1016/j.diabres.2018.02.023
2. [2]
  L.E. Edsberg, J.M. Black, M. Goldberg, et al., J. Wound. Ostomy. Cont. 43 (2016) 585-597. doi: 10.1097/WON.0000000000000281
3. [3]
  M.S. Hu, Z.N. Maan, J.C. Wu, et al., Ann. Biomed. Eng. 42 (2014) 1494–1507. doi: 10.1007/s10439-014-1010-z
4. [4]
  J. M. Ramirez-Acuna, S.A. Cardenas-Cadena, P.A. Marquez-Salas, et al., Antibiotics 8 (2019) 193. doi: 10.3390/antibiotics8040193
5. [5]
  H.N. Wilkinson, M.J. Hardman, Open Biol. 10 (2020) 200223. doi: 10.1098/rsob.200223
6. [6]
  V. Falanga, R.R. Isseroff, A.M. Soulika, et al., Nat. Rev. Dis. Primers. 8 (2022) 50. doi: 10.1038/s41572-022-00377-3
7. [7]
  Y.M. Niu, Q. Li, Y. Ding, et al., Adv. Drug Deliv. Rev. 146 (2019) 190–208. doi: 10.1016/j.addr.2018.06.002
8. [8]
  Z.Y. Qian, H.P. Wang, Y.T. Bai, et al., ACS Appl. Mater. Interfaces 12 (2020) 55659–55674. doi: 10.1021/acsami.0c17142
9. [9]
  Z.N. Yi, X.N. Xu, X.H. Meng, et al., Chin. Chem. Lett. 34 (2023) 108238. doi: 10.1016/j.cclet.2023.108238
10. [10]
  R. Zhang, G.H. Jiang, Q.Q. Gao, et al., Nanoscale 13 (2021) 15937–15951. doi: 10.1039/d1nr04687j
11. [11]
  M. Wang, C.G. Wang, M. Chen, et al., ACS Nano 13 (2019) 10279–10293. doi: 10.1021/acsnano.9b03656
12. [12]
  L.Z. Kong, Z. Wu, H.K. Zhao, et al., ACS Appl. Mater. Interfaces 10 (2018) 30103–30114. doi: 10.1021/acsami.8b09191
13. [13]
  J.Z. Zhu, C. Chen, J. Dong, et al., Chin. Chem. Lett. 34 (2023) 107514. doi: 10.1016/j.cclet.2022.05.028
14. [14]
  S. Ramadan, L.R. Guo, Y.J. Li, et al., Small 8 (2012) 3143–3150. doi: 10.1002/smll.201200783
15. [15]
  Z.K. Hu, H.J. Zhang, Z.Q. Li, et al., Chin. Chem. Lett. 35 (2024) 109527. doi: 10.1016/j.cclet.2024.109527
16. [16]
  D. Kupczyk, R. Bilski, R. Studziñska, et al., Postepy. Dermatol. Alergol. 39 (2022) 59–65. doi: 10.5114/ada.2020.100737
17. [17]
  W. Chen, C.Y. Wang, W. Liu, et al., Adv. Mater. 35 (2023) e2209041. doi: 10.1002/adma.202209041
18. [18]
  S.L. Zhu, B.J. Zhao, M.C. Li, et al., Bioact. Mater. 26 (2023) 306–320.
19. [19]
  B.D. Zheng, M.T. Xiao, Carbohydr. Polym. 299 (2023) 120228. doi: 10.1016/j.carbpol.2022.120228
20. [20]
  S. Sharma, V.K. Rai, R.K. Narang, et al., Life Sci. 290 (2022) 120096. doi: 10.1016/j.lfs.2021.120096
1. [1]
  Xicheng Li , Dong Mo , Shoushan Hu , Meng Pan , Meng Wang , Tingyu Yang , Changxing Qu , Yujia Wei , Jianan Li , Hanzhi Deng , Zhongwu Bei , Tianying Luo , Qingya Liu , Yun Yang , Jun Liu , Jun Wang , Zhiyong Qian . A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis. Chinese Chemical Letters, 2025, 36(9): 110674-. doi: 10.1016/j.cclet.2024.110674
2. [2]
  Yuyao Guan , Baoting Yu , Jun Ding , Tingting Sun , Zhigang Xie . BODIPY photosensitizers for antibacterial photodynamic therapy. Chinese Chemical Letters, 2025, 36(8): 110645-. doi: 10.1016/j.cclet.2024.110645
3. [3]
  Yueying Wang , Jianming Xiong , Linwei Xin , Yuanyuan Li , He Huang , Wenjun Miao . Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing. Chinese Chemical Letters, 2025, 36(4): 110003-. doi: 10.1016/j.cclet.2024.110003
4. [4]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
5. [5]
  Wen Zhong , Dan Zheng , Xukun Liao , Yadi Zhou , Yan Jiang , Ting Gao , Ming Li , Chengli Yang . Elaborate construction of pH-sensitive polymyxin B loaded nanoparticles for safe and effective treatment of carbapenem-resistant Klebsiella pneumoniae. Chinese Chemical Letters, 2025, 36(3): 110448-. doi: 10.1016/j.cclet.2024.110448
6. [6]
  Yue Ren , Kang Li , Yi-Zi Wang , Shao-Peng Zhao , Shu-Min Pan , Haojie Fu , Mengfan Jing , Yaming Wang , Fengyuan Yang , Chuntai Liu . Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement. Chinese Chemical Letters, 2025, 36(2): 110468-. doi: 10.1016/j.cclet.2024.110468
7. [7]
  Xiangrong Pan , Xixi Hou , Yuhang Du , Zhixin Pang , Shiyang He , Lan Wang , Jianxue Yang , Longfei Mao , Jianhua Qin , Haixia Wu , Baozhong Liu , Zhan Zhou , Lufang Ma , Chaoliang Tan . Solvent-mediated synthesis of 2D In-TCPP MOF nanosheets for enhanced photodynamic antibacterial therapy. Chinese Chemical Letters, 2025, 36(12): 110536-. doi: 10.1016/j.cclet.2024.110536
8. [8]
  Feng Cui , Fangman Chen , Xiaochun Xie , Chenyang Guo , Kai Xiao , Ziping Wu , Yinglu Chen , Junna Lu , Feixia Ruan , Chuanxu Cheng , Chao Yang , Dan Shao . Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation. Chinese Chemical Letters, 2024, 35(4): 108681-. doi: 10.1016/j.cclet.2023.108681
9. [9]
  Hongwei Ding , Jingjing Yang , Yongchen Shuai , Di Wei , Xueliang Liu , Guiying Li , Lin Jin , Jianliang Shen . In situ preparation of tannin-mediated CeO₂@CuS nanocomposites for multimodal wound therapy. Chinese Chemical Letters, 2025, 36(6): 110286-. doi: 10.1016/j.cclet.2024.110286
10. [10]
  Ruijun Song , Huixu Xie , Guiting Liu . Advances of MXene-based hydrogels for chronic wound healing. Chinese Chemical Letters, 2025, 36(7): 110442-. doi: 10.1016/j.cclet.2024.110442
11. [11]
  Xingchen Li , Lin Guan , Xiaoli Li , Xiaolan Ou , Wenlai Guo , Andrei V. Zvyagin , Wenrui Qu , Bai Yang , Quan Lin . A hierarchical hydrogel dressing with continuous biochemical gradient for immunoregulation, nerve repair and angiogenesis of refractory diabetes wounds. Chinese Chemical Letters, 2025, 36(9): 110661-. doi: 10.1016/j.cclet.2024.110661
12. [12]
  Min Zhang , Ye Chen , Yanan Li , Yifan Zhao , Bai Lv , Jie Cao , Bing Yu , Hailin Cong . Manipulating extracellular matrix to enhance intratumor drug delivery for nanomaterial-based photothermal therapy. Chinese Chemical Letters, 2025, 36(12): 111588-. doi: 10.1016/j.cclet.2025.111588
13. [13]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
14. [14]
  Jiajia Wang , XinXin Ge , Yajing Xiang , Xiaoliang Qi , Ying Li , Hangbin Xu , Erya Cai , Chaofan Zhang , Yulong Lan , Xiaojing Chen , Yizuo Shi , Zhangping Li , Jianliang Shen . An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing. Chinese Chemical Letters, 2025, 36(2): 109819-. doi: 10.1016/j.cclet.2024.109819
15. [15]
  Mengyu Chen , Qinglin Zhou , Tianyun Qin , Ningyao Sun , Yuxi Chen , Yuwei Gong , Xingyi Li , Jinsong Liu . An ionic liquid-reinforced gelatin hydrogel with strong adhesion, antibacterial and anti-inflammatory properties for treating oral ulcers. Chinese Chemical Letters, 2025, 36(7): 110441-. doi: 10.1016/j.cclet.2024.110441
16. [16]
  Bing Xie , Qi Jiang , Fang Zhu , Yaoyao Lai , Yueming Zhao , Wei He , Pei Yang . Transdermal delivery of amphotericin B using deep eutectic solvents for antifungal therapy. Chinese Chemical Letters, 2025, 36(5): 110508-. doi: 10.1016/j.cclet.2024.110508
17. [17]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
18. [18]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
19. [19]
  Dexuan Xiao , Tianyu Chen , Tianxu Zhang , Sirong Shi , Mei Zhang , Xin Qin , Yunkun Liu , Longjiang Li , Yunfeng Lin . Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib. Chinese Chemical Letters, 2024, 35(4): 108602-. doi: 10.1016/j.cclet.2023.108602
20. [20]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(1061)
HTML views(33)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142