Citation: Ruijianghan Shi, Yujie Zhu, Weitong Lu, Yuhan Shao, Yang Chen, Mi Zhou, Yunfeng Lin, Sirong Shi. Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair[J]. Chinese Chemical Letters, ;2025, 36(5): 110241. doi: 10.1016/j.cclet.2024.110241 shu

Tetrahedral framework nucleic acids enhance osteogenic differentiation and prevent apoptosis for dental follicle stem cell therapy in diabetic bone repair

Ruijianghan Shi ^{a, b} ,
Yujie Zhu ^{a, b} ,
Weitong Lu ^{a, b} ,
Yuhan Shao ^{a, b} ,
Yang Chen ^c ,
Mi Zhou ^{a, b} ,
Yunfeng Lin ^{a, b} ,
Sirong Shi ^{a, b, *,}

a.
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu 610041, China
c.
Department of Pediatric Surgery, Department of Liver Surgery & Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China

sirongshi@scu.edu.cn

Received Date: 21 May 2024
Revised Date: 9 July 2024
Accepted Date: 10 July 2024
Available Online: 14 July 2024

Figures(5)

Hyperglycemia resulting from diabetes mellitus (DM) exacerbates osteoporosis and fractures, damaging bone regeneration due to impaired healing capacity. Stem cell therapy offers the potential for bone repair, accelerating the healing of bone defects by introducing stem cells with osteogenic differentiation ability. Dental follicle stem cells (DFSCs) are a newly emerging type of dental stem cells that not only have the potential for multipotent differentiation but also hold easy accessibility and can stand long-term storage. However, DM-associated oxidative stress and inflammation elevate the risk of DFSCs dysfunction and apoptosis, diminishing stem cell therapy efficacy. Recent nanomaterial advances, particularly in DNA nanostructures like tetrahedral framework nucleic acids (tFNAs), have been promising candidates for modulating cellular behaviors. Accumulating experiments have shown that tFNAs' cell proliferation and migration-promoting ability and induce osteogenic differentiation of stem cells. Meanwhile, tFNAs can scavenge reactive oxygen species (ROS) and downregulate the secretion of inflammatory factors by inhibiting various inflammation-related signaling pathways. Here, we applied tFNAs to modify DFSCs and observed enhanced osteogenic differentiation alongside ROS scavenging and anti-inflammatory effects mediated by suppressing the ROS/mitogen-activated protein kinases (MAPKs)/nuclear factor kappa-B (NF-κB) signaling pathway. This intervention reduced stem cell apoptosis, bolstering stem cell therapy efficacy in DM. Our study establishes a simple yet potent tFNAs-DFSCs system, offering potential as a bone repair agent for future DM treatment.
- Tetrahedral framework nucleic acids,
- DNA nanomaterials,
- Diabetes mellitus,
- Dental follicle stem cells,
- ROS/MAPKs/NF-κB pathway
1. [1]
  A. Scott, D. Chambers, E. Goyder, et al., PLoS ONE 12 (2017) e0177210. doi: 10.1371/journal.pone.0177210
2. [2]
  X. Yang, M. Bao, Y. Fang, et al., J. Transl. Med. 19 (2021) 283. doi: 10.1017/s0014479721000259
3. [3]
  Y. An, H. Zhang, C. Wang, et al., FASEB J. 33 (2019) 12515–12527. doi: 10.1096/fj.201802805rr
4. [4]
  L.C. Hofbauer, B. Busse, R. Eastell, et al., Lancet Diabetes Endocrinol. 10 (2022) 207–220. doi: 10.1016/S2213-8587(21)00347-8
5. [5]
  L. Bai, M. Feng, Q. Zhang, et al., Adv. Funct. Mater. (2024), https://doi.org/10.1038/s41413-024-00319-7. doi: 10.1038/s41413-024-00319-7
6. [6]
  S.C. Tao, X.R. Li, W.J. Wei, et al., Biomaterials 283 (2022), https://doi.org/10.1002/adfm.202314789. doi: 10.1002/adfm.202314789
7. [7]
  L. Yang, Y. Liu, L. Sun, et al., Nanomicro. Lett. 14 (2021) 4.
8. [8]
  R. Bi, P. Lyu, Y. Song, et al., Biomolecules 11 (2021) 997. doi: 10.3390/biom11070997
9. [9]
  M. Rezai-Rad, J.F. Bova, M. Orooji, et al., Cytotherapy 17 (2015) 1572–1581. doi: 10.1016/j.jcyt.2015.07.013
10. [10]
  X. Luan, Y. Ito, S. Dangaria, T.G. Diekwisch, Stem Cells Dev. 15 (2006) 595–608. doi: 10.1089/scd.2006.15.595
11. [11]
  T. Zhou, J. Pan, P. Wu, et al., Stem Cells Int. 2019 (2019) 9159605.
12. [12]
  B.W. Park, S.J. Jang, J.H. Byun, et al., J. Tissue Eng. Regen. Med. 11 (2017) 489–500. doi: 10.1002/term.1945
13. [13]
  H.J. Lee, C.W. Chae, H.J. Han, Biomed. Pharmacother. 168 (2023) 115759. doi: 10.1016/j.biopha.2023.115759
14. [14]
  Q. Zhang, X.X. Wan, X.M. Hu, et al., Front. Cell. Dev. Biol. 9 (2021) 809656. doi: 10.3389/fcell.2021.809656
15. [15]
  L. Zhang, Z. Bei, T. Li, Z. Qian, Bioact. Mater. 29 (2023) 132–150.
16. [16]
  Y.L. Zhang, Y. An, L.J. Sun, et al., Front. Endocrinol. 14 (2023) 1152845. doi: 10.3389/fendo.2023.1152845
17. [17]
  B. Yang, T.S. Johnson, G.L. Thomas, et al., Kidney Int. 62 (2002) 1301–1313. doi: 10.1111/j.1523-1755.2002.kid587.x
18. [18]
  S. Cheng, H.N. Wang, L.J. Xu, et al., J. Neuroinflamm. 18 (2021) 182. doi: 10.1007/978-3-030-77080-8_16
19. [19]
  Y. Chen, X. Chen, B. Zhang, et al., Signal Transduct. Tar. 9 (2024) 28. doi: 10.1038/s41392-024-01736-0
20. [20]
  Q. Wang, J. Cheng, F. Liu, et al., Adv. Sci. (2024), https://doi.org/10.1002/advs.202306622. doi: 10.1002/advs.202306622
21. [21]
  D. Xiao, T. Chen, T, Zhang, et al., Chin. Chem. Lett. 35 (2024) 108602. doi: 10.1016/j.cclet.2023.108602
22. [22]
  Y. Wen, M. Zhang, Y. Yao, et al., Chin. Chem. Lett. 34 (2023) 107549. doi: 10.1016/j.cclet.2022.05.063
23. [23]
  Y. Li, Z. Cai, W. Ma, et al., Bone Res. 12 (2024) 14. doi: 10.1038/s41413-024-00319-7
24. [24]
  Y. Ge, Q. Wang, Y. Yao, et al., Adv. Sci. (2024), https://doi.org/10.1002/advs.202308701. doi: 10.1002/advs.202308701
25. [25]
  Y. Liu, C. Zeng, Z. Huang, et al., Chem. Eng. J. 486 (2024) 150419. doi: 10.1016/j.cej.2024.150419
26. [26]
  J. Sun, Y. Gao, Y. Yao, et al., Chem. Eng. J. 487 (2024) 150706. doi: 10.1016/j.cej.2024.150706
27. [27]
  W. Zou, J. Lu, L. Zhang, et al., J. Nanobiotechnol. 22 (2024) 113. doi: 10.1186/s12951-024-02365-z
28. [28]
  S. Lin, Q. Zhang, S. Li, et al., ACS Appl. Mater. Interfaces 12 (2020) 11397–11408. doi: 10.1021/acsami.0c00874
29. [29]
  M. Liu, W. Ma, Q. Li, et al., Cell Prolif. 52 (2019) e12511. doi: 10.1111/cpr.12511
30. [30]
  Z. Wang, H. Lu, T. Tang, et al., Cell Prolif. 55 (2022) e13316. doi: 10.1111/cpr.13316
31. [31]
  M. Zhou, N.X. Liu, S.R. Shi, et al., Nanomedicine 14 (2018) 1227–1236. doi: 10.1016/j.nano.2018.02.004
32. [32]
  B. Guo, T. Chen, D. Xiao, et al., Chin. Chem. Lett. 33 (2022) 2517–2521. doi: 10.1007/s12221-022-4028-0
33. [33]
  M. Zhou, S. Gao, X. Zhang, et al., Bioact. Mater. 6 (2021) 1676–1688.
34. [34]
  P. Li, L. Fu, C. Ning, et al., Cell Prolif. (2024), https://doi.org/10.1111/cpr.13605. doi: 10.1111/cpr.13605
35. [35]
  X. Chen, J. He, Y. Xie, et al., Cell Prolif. 56 (2023) e13424. doi: 10.1111/cpr.13424
36. [36]
  W. Ma, X. Shao, D. Zhao, et al., ACS Appl. Mater. Interfaces 10 (2018) 7892–7900. doi: 10.1021/acsami.8b00833
37. [37]
  D. Genç, M. Sezer Kürkçü, G. Yiğittürk, et al., Arch. Rheumatol. 37 (2022) 94–109. doi: 10.46497/archrheumatol.2022.8891
38. [38]
  G. Mori, A. Ballini, C. Carbone, et al., Int. J. Med. Sci. 9 (2012) 480–487. doi: 10.7150/ijms.4583
39. [39]
  T. Zhang, T. Tian, R. Zhou, et al., Nat. Protoc. 15 (2020) 2728–2757. doi: 10.1038/s41596-020-0355-z
40. [40]
  L. Liang, J. Li, Q. Li, et al., Angew. Chem. Int. Ed. 53 (2014) 7745–7750. doi: 10.1002/anie.201403236
41. [41]
  T. Tian, C. Zhang, J. Li, et al., Small 17 (2021) e2100837. doi: 10.1002/smll.202100837
42. [42]
  J.M. Tang, J.N. Wang, L. Zhang, et al., Cardiovasc. Res. 91 (2011) 402–411. doi: 10.1093/cvr/cvr053
43. [43]
  Y. Chen, T. Wu, S. Huang, et al., ACS Appl. Mater. Interfaces 11 (2019) 14608–14618. doi: 10.1021/acsami.9b01532
44. [44]
  Z. Qian, H. Wang, Y. Bai, et al., ACS Appl. Mater. Interfaces 12 (2020) 55659–55674. doi: 10.1021/acsami.0c17142
45. [45]
  P. Ramos-García, J.A. Gil-Montoya, C. Scully, et al., Oral Dis. 23 (2017) 897–912. doi: 10.1111/odi.12620
46. [46]
  W. Ren, M. Chai, M. Jiang, et al., Mol. Biol. Rep. 49 (2022) 2723–2733. doi: 10.1007/s11033-021-07082-6
47. [47]
  T. Kawane, X. Qin, Q. Jiang, et al., Sci. Rep. 8 (2018) 13551. doi: 10.1038/s41598-018-31853-0
48. [48]
  E. Zherebitskaya, E. Akude, D.R. Smith, P. Fernyhough, Diabetes 58 (2009) 1356–1364. doi: 10.2337/db09-0034
49. [49]
  Y. Yao, X. Lei, Y. Wang, et al., ACS Nano 17 (2023) 22334–22354. doi: 10.1021/acsnano.3c04462
50. [50]
  X. Qin, N. Li, M. Zhang, et al., Nanoscale 11 (2019) 20667–20675. doi: 10.1039/c9nr07171g
51. [51]
  H. Wei, K. Yi, F. Li, et al., Adv. Mater. (2023), https://doi.org/10.1002/adma.202305826. doi: 10.1002/adma.202305826
52. [52]
  H. Kim, Y.D. Lee, H.J. Kim, et al., J. Bone Miner. Res. 32 (2017) 397–406. doi: 10.1002/jbmr.2974
53. [53]
  C. Bi, Y. Ma, Z. Wu, et al., Plant. Mol. Biol. 94 (2017) 197–213. doi: 10.1007/s11103-017-0603-y
54. [54]
  T. Wu, X. Chen, Y. Wang, et al., Nanomedicine 14 (2018) 2215–2226. doi: 10.1016/j.nano.2018.06.010
55. [55]
  M. Xiong, Y. Zhao, H. Mo, et al., Int. Immunopharmacol. 100 (2021) 108165. doi: 10.1016/j.intimp.2021.108165
56. [56]
  Y. Xu, J. Chen, W. Jiang, et al., Small 18 (2022) e2102848. doi: 10.1002/smll.202102848
57. [57]
  X. Yin, X. Zhuang, W. Luo, et al., Front. Immunol. 13 (2022) 990297. doi: 10.3389/fimmu.2022.990297
58. [58]
  Y. Zhang, S. Xu, K. Li, et al., Ecotoxicol. Environ. Saf. 252 (2023) 114607. doi: 10.1016/j.ecoenv.2023.114607
59. [59]
  H.S. Choi, A.P. Mathew, S. Uthaman, et al., J. Nanobiotechnology 20 (2022) 205. doi: 10.1080/07341512.2022.2129278
60. [60]
  M. Zhou, T. Zhang, B. Zhang, et al., ACS Nano 16 (2022) 1456–1470. doi: 10.1021/acsnano.1c09626
61. [61]
  C.K. Chan, H. Supriady, B.H. Goh, H.A. Kadir, J. Ethnopharmacol. 168 (2015) 291–304. doi: 10.1016/j.jep.2015.03.072
62. [62]
  C. Park, H.J. Cha, M.Y. Kim, et al., Antioxidants 11 (2022) 2353. doi: 10.3390/antiox11122353
63. [63]
  P.E. Czabotar, A.J. Garcia-Saez, Nat. Rev. Mol. Cell Biol. 24 (2023) 732–748. doi: 10.1038/s41580-023-00629-4
64. [64]
  M. Certo, V. Del Gaizo Moore, M. Nishino, et al., Cancer Cell 9 (2006) 351–365. doi: 10.1016/j.ccr.2006.03.027
65. [65]
  A. Nechushtan, C.L. Smith, I. Lamensdorf, et al., J. Cell Biol. 153 (2001) 1265–1276. doi: 10.1083/jcb.153.6.1265
66. [66]
  H. Ze, T. Li, X. He, et al., Respir. Res. 21 (2020) 229. doi: 10.1186/s12931-020-01495-w
67. [67]
  H.A. Park, K. Broman, E.A. Jonas, Neural Regen. Res. 16 (2021) 12–15. doi: 10.4103/1673-5374.286946
68. [68]
  Y. Liu, X. Gong, J. Wang, et al., Environ. Toxicol. 37 (2022) 2058–2071. doi: 10.1002/tox.23550
69. [69]
  H. Rizwan, S. Kumar, G. Kumari, A. Pal, Life Sci. 312 (2023) 121208. doi: 10.1016/j.lfs.2022.121208
70. [70]
  C. Lou, C. Lin, W. Wang, et al., J. Ethnopharmacol. 316 (2023) 116744. doi: 10.1016/j.jep.2023.116744
71. [71]
  F.F. Wang, P.Y. Zhao, X.J. He, et al., Front. Cell Infect. Microbiol. 12 (2022) 827750. doi: 10.3389/fcimb.2022.827750
72. [72]
  N. Yan, Y. Liu, S. Liu, et al., Mol. Neurobiol. 53 (2016) 4449–4460. doi: 10.1007/s12035-015-9380-2
73. [73]
  T. Sessler, S. Healy, A. Samali, E. Szegezdi, Pharmacol. Ther. 140 (2013) 186–199. doi: 10.1016/j.pharmthera.2013.06.009
74. [74]
  C.H. Su, S.P. Chen, L.Y. Chen, et al., Ecotoxicol. Environ. Saf. 228 (2021) 112962. doi: 10.1016/j.ecoenv.2021.112962
75. [75]
  J. Kizhakkayil, F. Thayyullathil, S. Chathoth, et al., Free Radic. Biol. Med. 52 (2012) 1854–1864.
76. [76]
  K. Aral, C.A. Aral, Y. Kapila, J. Periodontol. 90 (2019) 288–294. doi: 10.1002/jper.17-0716
77. [77]
  L. Xu, Y. Zhang, X. Qu, et al., Mol. Oncol. 11 (2017) 1733–1751. doi: 10.1002/1878-0261.12140
78. [78]
  R. Gong, D. Wang, G. Abbas, et al., Sci. China Life Sci. 65 (2022) 540–549. doi: 10.1007/s11427-021-1986-7
79. [79]
  Z. Chen, H. Gao, L. Wang, et al., Chem. Biol. Interact. 316 (2020) 108921. doi: 10.1016/j.cbi.2019.108921
80. [80]
  C. Park, H.J. Cha, H. Hwangbo, et al., Antioxidants 12 (2023) 1410. doi: 10.3390/antiox12071410
81. [81]
  E.S. Jo, N. Sp, D.Y. Kang, et al., Molecules 25 (2020) 2342. doi: 10.3390/molecules25102342
82. [82]
  I. Rahman, P.S. Gilmour, L.A. Jimenez, W. MacNee, Mol. Cell Biochem. 234-235 (2002) 239–248. doi: 10.1023/A:1015905010086
83. [83]
  X. Sui, N. Kong, L. Ye, et al., Cancer Lett. 344 (2014) 174–179. doi: 10.1016/j.canlet.2013.11.019
84. [84]
  Y. Li, C. Shang, Z. Liu, et al., Cell Commun. Signal 20 (2022) 134. doi: 10.1186/s12964-022-00940-1
85. [85]
  Q. Qian, X. Cao, B. Wang, et al., J. Cell Physiol. 234 (2019) 5953–5963. doi: 10.1002/jcp.27061
86. [86]
  N. Fujiwara, S. Yamashita, M. Okamoto, et al., Ecotoxicol. Environ. Saf. 260 (2023) 115089. doi: 10.1016/j.ecoenv.2023.115089
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  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
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  Jia-Li Xie , Tian-Jin Xie , Yu-Jie Luo , Kai Mao , Cheng-Zhi Huang , Yuan-Fang Li , Shu-Jun Zhen . Octopus-like DNA nanostructure coupled with graphene oxide enhanced fluorescence anisotropy for hepatitis B virus DNA detection. Chinese Chemical Letters, 2024, 35(6): 109137-. doi: 10.1016/j.cclet.2023.109137
9. [9]
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  Chang Liu , Tao Wu , Lijiao Deng , Xuzi Li , Xin Fu , Shuzhen Liao , Wenjie Ma , Guoqiang Zou , Hai Yang . Programmed DNA walkers for biosensors. Chinese Chemical Letters, 2024, 35(9): 109307-. doi: 10.1016/j.cclet.2023.109307
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  Yang Feng , Yang-Qing Tian , Yong-Qiang Zhao , Sheng-Jun Chen , Bi-Feng Yuan . Dynamic deformylation of 5-formylcytosine and decarboxylation of 5-carboxylcytosine during differentiation of mouse embryonic stem cells into mouse neurons. Chinese Chemical Letters, 2024, 35(11): 109656-. doi: 10.1016/j.cclet.2024.109656
13. [13]
  Liangji Chen , Zhen Yuan , Fudong Feng , Xin Zhou , Zhile Xiong , Wuji Wei , Hao Zhang , Banglin Chen , Shengchang Xiang , Zhangjing Zhang . A hydrogen-bonded organic framework containing fluorescent carbazole and responsive pyridyl units for sensing organic acids. Chinese Chemical Letters, 2024, 35(9): 109344-. doi: 10.1016/j.cclet.2023.109344
14. [14]
  Ping Liu , Fei Yu . Covalent organic framework ionomers for medium-temperature fuel cells. Chinese Journal of Structural Chemistry, 2025, 44(4): 100465-100465. doi: 10.1016/j.cjsc.2024.100465
15. [15]
  Ningxiang Wu , Huaping Zhao , Yong Lei . Nanomaterials with highly ordered nanostructures: Definition, influence and future challenge. Chinese Journal of Structural Chemistry, 2024, 43(11): 100392-100392. doi: 10.1016/j.cjsc.2024.100392
16. [16]
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17. [17]
  Wenbiao Zhang , Bolong Yang , Zhonghua Xiang . Atomically dispersed Cu-based metal-organic framework directly for alkaline polymer electrolyte fuel cells. Chinese Chemical Letters, 2025, 36(2): 109630-. doi: 10.1016/j.cclet.2024.109630
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19. [19]
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20. [20]
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