Citation: Beitong Zhu, Xiaorui Yang, Lirong Jiang, Tianhong Chen, Shuangfei Wang, Lintao Zeng. A portable and versatile fluorescent platform for high-throughput screening of toxic phosgene, diethyl chlorophosphate and volatile acyl chlorides[J]. Chinese Chemical Letters, ;2025, 36(1): 110222. doi: 10.1016/j.cclet.2024.110222 shu

A portable and versatile fluorescent platform for high-throughput screening of toxic phosgene, diethyl chlorophosphate and volatile acyl chlorides

Beitong Zhu ^{a, 1} ,
Xiaorui Yang ^{a, 1} ,
Lirong Jiang ^{b, *,} ,
Tianhong Chen ^{c, *,} ,
Shuangfei Wang ^a ,
Lintao Zeng ^{a, *,}

a.
Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
b.
School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
c.
College of Chemistry, Beijing Normal University, Beijing 100875, China

jianglirong_2000@163.com

cthniu@163.com

zlt1981@126.com

Received Date: 26 May 2024
Revised Date: 2 July 2024
Accepted Date: 5 July 2024
Available Online: 6 July 2024

Figures(8)

Highly toxic phosgene, diethyl chlorophosphate (DCP) and volatile acyl chlorides endanger our life and public security. To achieve facile sensing and discrimination of multiple target analytes, herein, we presented a single fluorescent probe (BDP-CHD) for high-throughput screening of phosgene, DCP and volatile acyl chlorides. The probe underwent a covalent cascade reaction with phosgene to form boron dipyrromethene (BODIPY) with bright green fluorescence. By contrast, DCP, diphosgene and acyl chlorides can covalently assembled with the probe, giving rise to strong blue fluorescence. The probe has demonstrated high-throughput detection capability, high sensitivity, fast response (within 3 s) and parts per trillion (ppt) level detection limit. Furthermore, a portable platform based on BDP-CHD was constructed, which has achieved high-throughput discrimination of 16 analytes through linear discriminant analysis (LDA). Moreover, a smartphone adaptable RGB recognition pattern was established for the quantitative detection of multi-analytes. Therefore, this portable fluorescence sensing platform can serve as a versatile tool for rapid and high-throughput detection of toxic phosgene, DCP and volatile acyl chlorides. The proposed "one for more" strategy simplifies multi-target discrimination procedures and holds great promise for various sensing applications.
- Fluorescent platform,
- High throughput,
- BODIPY,
- Linear discriminant analysis,
- Phosgene,
- Acyl chloride,
- Diethyl chlorophosphate
1. [1]
  M.E. Swanson, H.L. Greene, S. Qutubuddin, et al., Appl. Catal. B: Environ. Energy 52 (2004) 91–108. doi: 10.1016/j.apcatb.2004.03.015
2. [2]
  X. Zhou, Y. Zeng, L. Chen, et al., Angew. Chem. Int. Ed. 55 (2016) 4729–4733. doi: 10.1002/anie.201601346
3. [3]
  B. Zhu, R. Sheng, T. Chen, et al., Coord. Chem. Rev. 463 (2022) 214527. doi: 10.1016/j.ccr.2022.214527
4. [4]
  L. Chen, D. Wu, J.M. Kim, et al., Anal. Chem. 89 (2017) 12596–12601. doi: 10.1021/acs.analchem.7b03988
5. [5]
  F. Xiao, D. Lei, C. Liu, et al., Angew. Chem. Int. Ed. 63 (2024) e202400453. doi: 10.1002/anie.202400453
6. [6]
  Q. Chen, J. Liu, S. Liu, et al., Anal. Chem. 95 (2023) 4390–4394. doi: 10.1021/acs.analchem.2c04891
7. [7]
  W. Mo, Z. Zhu, F. Kong, et al., Nat. Commun. 13 (2022) 5189. doi: 10.1038/s41467-022-32878-w
8. [8]
  M. Kumar, N. Kaur, N. Singh, et al., Sensor. Actuat. B: Chem. 392 (2023) 134080. doi: 10.1016/j.snb.2023.134080
9. [9]
  B. Huo, M. Du, A. Shen, et al., Anal. Chem. 91 (2019) 10979–10983. doi: 10.1021/acs.analchem.9b01006
10. [10]
  L. Zeng, H. Zeng, L. Jiang, et al., Anal. Chem. 91 (2019) 12070–12076. doi: 10.1021/acs.analchem.9b03230
11. [11]
  L. Chen, D. Wu, J. Yoon, ACS Sens. 3 (2018) 27–43. doi: 10.1021/acssensors.7b00816
12. [12]
  Q. Wang, H. Wu, A. Gao, et al., Chin. Chem. Lett. 34 (2023) 107644. doi: 10.1016/j.cclet.2022.06.067
13. [13]
  T. Chen, L. Jiang, H.Q. Yuan, et al., Sensor. Actuat. B: Chem. 319 (2020) 128289. doi: 10.1016/j.snb.2020.128289
14. [14]
  X. Yu, L. Fu, T. Wang, et al., Chin. Chem. Lett. 35 (2024) 109167. doi: 10.1016/j.cclet.2023.109167
15. [15]
  G. Yue, S. Su, N. Li, et al., Coordin. Chem. Rev. 311 (2016) 75–84. doi: 10.1016/j.ccr.2015.11.009
16. [16]
  W.Q. Meng, A.C. Sedgwick, N. Kwon, et al., Chem. Soc. Rev. 52 (2022) 601–662. doi: 10.2991/978-94-6463-052-7_70
17. [17]
  J. Yang, M. Gao, M. Zhang, et al., Coordin. Chem. Rev. 493 (2023) 215289. doi: 10.1016/j.ccr.2023.215289
18. [18]
  N. Couzon, J. Dhainaut, C. Campagne, et al., Coord. Chem. Rev. 467 (2022) 214598. doi: 10.1016/j.ccr.2022.214598
19. [19]
  T. Islamoglu, Z. Chen, M.C. Wasson, et al., Chem. Rev. 120 (2020) 8130–8160. doi: 10.1021/acs.chemrev.9b00828
20. [20]
  G.G. Esposito, D. Lillian, G.E. Podolak, et al., Anal. Chem. 49 (1977) 1774–1778. doi: 10.1021/ac50020a035
21. [21]
  J. Liu, L. Zhang, W. Zeng, et al., Chin. Chem. Lett. 34 (2023) 108141. doi: 10.1016/j.cclet.2023.108141
22. [22]
  H.B. Singh, D. Lillian, A. Appleby, et al., Anal. Chem. 47 (1975) 860–864. doi: 10.1021/ac60356a003
23. [23]
  W. Li, X. Zhang, S. Chen, et al., Chin. Chem. Lett. 33 (2022) 4405–4410. doi: 10.1016/j.cclet.2021.12.026
24. [24]
  I. Roy, A. Garci, Y. Beldjoudi, et al., J. Am. Chem. Soc. 142 (2020) 16600–16609. doi: 10.1021/jacs.0c05445
25. [25]
  H. Chen, X. Zeng, H.P. Tham, et al., Angew. Chem. Int. Ed. 58 (2019) 7641–7646. doi: 10.1002/anie.201900886
26. [26]
  W. Ren, Y. Zhang, W.Y. Liang, et al., Sensor. Actuat. B: Chem. 330 (2020) 129330.
27. [27]
  J. Zhang, C. Yue, Y. Ke, et al., Adv. Agroc. 2 (2023) 127–141. doi: 10.3390/wevj14050127
28. [28]
  D. Zhang, L. Wang, X. Yuan, et al., Angew. Chem. Int. Ed. 59 (2019) 695–699. doi: 10.3390/ani9090695
29. [29]
  Q. Hu, C. Duan, J. Wu, et al., Anal. Chem. 90 (2018) 8686–8691. doi: 10.1021/acs.analchem.8b02119
30. [30]
  T.I. Kim, B. Hwang, J. Bouffard, et al., Anal. Chem. 89 (2017) 12837–12842. doi: 10.1021/acs.analchem.7b03316
31. [31]
  H.C. Xia, X.H. Xu, Q.H. Song, ACS Sens. 2 (2016) 178–182. doi: 10.1002/ana.24560
32. [32]
  L. Zeng, H. Zeng, S. Wang, et al., Chem. Commoun. 55 (2019) 13753–13756. doi: 10.1039/c9cc07437f
33. [33]
  T. Chen, L. Jiang, J.T. Hou, et al., J. Mater. Chem. A 8 (2020) 24695–24702. doi: 10.1039/d0ta08333j
34. [34]
  X. Liu, N. Li, M. Li, et al., Coordin. Chem. Rev. 404 (2019) 213109.
35. [35]
  X. Chen, F. Wang, J.Y. Hyun, et al., Chem. Soc. Rev. 45 (2016) 2976–3016. doi: 10.1039/C6CS00192K
36. [36]
  Y. Wang, Y. Qin, X. Zhao, et al., Chin. Chem. Lett. 34 (2023) 107576. doi: 10.1016/j.cclet.2022.05.090
37. [37]
  S. Bencic-Nagale, T. Sternfeld, D.R. Walt, et al., J. Am. Chem. Soc. 128 (2006) 5041–5048. doi: 10.1021/ja057057b
38. [38]
  T.I. Kim, S.B. Maity, J. Bouffard, et al., Anal. Chem. 88 (2016) 9259–9263. doi: 10.1021/acs.analchem.6b02516
39. [39]
  L. Wang, A. Mei, N. Li, et al., Chin. Chem. Lett. 35 (2024) 108974. doi: 10.1016/j.cclet.2023.108974
40. [40]
  T.J. Dale, J. Rebek, Angew. Chem. Int. Ed. 48 (2009) 7850–7852. doi: 10.1002/anie.200902820
41. [41]
  Y.J. Jang, O.G. Tsay, D.P. Murale, et al., Chem. Commun. 50 (2014) 7531–7534. doi: 10.1039/C4CC02689F
42. [42]
  M.S.J. Khan, Y.W. Wang, M.O. Senge, et al., J. Hazard. Mater. 342 (2017) 10–19.
43. [43]
  L. Zheng, R.A. Jon, S.S. Kenneth, Chem. Rev. 119 (2018) 231–292. doi: 10.3390/met8040231
44. [44]
  L. Zheng, S.S. Kenneth, Acc. Chem. Res. 54 (2020) 950–960. doi: 10.1109/iciea48937.2020.9248381
45. [45]
  B. Chen, X. Mo, X. Qu, et al., Anal. Chem. 96 (2024) 6228–6235. doi: 10.1021/acs.analchem.3c05282
46. [46]
  Y. Mei, Q.W. Zhang, Q. Gu, et al., J. Am. Chem. Soc. 144 (2022) 2351–2359. doi: 10.1021/jacs.1c12959
47. [47]
  X. Feng, X. Zhang, J. Huang, et al., Anal. Chem. 94 (2022) 5946–5952. doi: 10.1021/acs.analchem.2c00374
48. [48]
  M. Wu, B. Yang, L. Shi, et al., Anal. Chem. 95 (2023) 3486–4392. doi: 10.1021/acs.analchem.2c05447
49. [49]
  A.J. Pluchinsky, D.J. Wackelin, X. Huang, et al., J. Am. Chem. Soc. 142 (2020) 19804–19808. doi: 10.1021/jacs.0c07828
50. [50]
  X. Gao, S. Li, F. Ding, et al., Angew. Chem. Int. Ed. 58 (2019) 8719–8723. doi: 10.1002/anie.201901997
51. [51]
  H. Yan, F. Huo, Y. Yue, et al., J. Am. Chem. Soc. 143 (2020) 318–325. doi: 10.1177/2050157919884718
52. [52]
  L. Guo, M. Tian, Z. Zhang, et al., J. Am. Chem. Soc. 143 (2021) 3169–3179. doi: 10.1021/jacs.0c12323
53. [53]
  X. Ma, Y. Huang, W. Chen, et al., Angew. Chem. Int. Ed. 62 (2023) e202216109. doi: 10.1002/anie.202216109
54. [54]
  D. Li, T. Shen, X. Xue, et al., Sci. China Chem. 66 (2023) 2329-1338.
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