Citation: Beitong Zhu, Xiaorui Yang, Lirong Jiang, Tianhong Chen, Shuangfei Wang, Lintao Zeng. A portable and versatile fluorescent platform for high-throughput screening of toxic phosgene, diethyl chlorophosphate and volatile acyl chlorides[J]. Chinese Chemical Letters, ;2025, 36(1): 110222. doi: 10.1016/j.cclet.2024.110222 shu

A portable and versatile fluorescent platform for high-throughput screening of toxic phosgene, diethyl chlorophosphate and volatile acyl chlorides

Beitong Zhu ^{a, 1} ,
Xiaorui Yang ^{a, 1} ,
Lirong Jiang ^{b, *,} ,
Tianhong Chen ^{c, *,} ,
Shuangfei Wang ^a ,
Lintao Zeng ^{a, *,}

a.
Guangxi Key Laboratory of Clean Pulp & Papermaking and Pollution Control, School of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China
b.
School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530006, China
c.
College of Chemistry, Beijing Normal University, Beijing 100875, China

jianglirong_2000@163.com

cthniu@163.com

zlt1981@126.com

Received Date: 26 May 2024
Revised Date: 2 July 2024
Accepted Date: 5 July 2024
Available Online: 6 July 2024

Figures(8)

Highly toxic phosgene, diethyl chlorophosphate (DCP) and volatile acyl chlorides endanger our life and public security. To achieve facile sensing and discrimination of multiple target analytes, herein, we presented a single fluorescent probe (BDP-CHD) for high-throughput screening of phosgene, DCP and volatile acyl chlorides. The probe underwent a covalent cascade reaction with phosgene to form boron dipyrromethene (BODIPY) with bright green fluorescence. By contrast, DCP, diphosgene and acyl chlorides can covalently assembled with the probe, giving rise to strong blue fluorescence. The probe has demonstrated high-throughput detection capability, high sensitivity, fast response (within 3 s) and parts per trillion (ppt) level detection limit. Furthermore, a portable platform based on BDP-CHD was constructed, which has achieved high-throughput discrimination of 16 analytes through linear discriminant analysis (LDA). Moreover, a smartphone adaptable RGB recognition pattern was established for the quantitative detection of multi-analytes. Therefore, this portable fluorescence sensing platform can serve as a versatile tool for rapid and high-throughput detection of toxic phosgene, DCP and volatile acyl chlorides. The proposed "one for more" strategy simplifies multi-target discrimination procedures and holds great promise for various sensing applications.
- Fluorescent platform,
- High throughput,
- BODIPY,
- Linear discriminant analysis,
- Phosgene,
- Acyl chloride,
- Diethyl chlorophosphate
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