Citation: Yunli Xu, Xuwen Da, Lei Wang, Yatong Peng, Wanpeng Zhou, Xiulian Liu, Yao Wu, Wentao Wang, Xuesong Wang, Qianxiong Zhou. Ru(Ⅱ)-based aggregation-induced emission (AIE) agents with efficient ¹O₂ generation, photo-catalytic NADH oxidation and anticancer activity[J]. Chinese Chemical Letters, ;2025, 36(5): 110168. doi: 10.1016/j.cclet.2024.110168 shu

Ru(Ⅱ)-based aggregation-induced emission (AIE) agents with efficient ¹O₂ generation, photo-catalytic NADH oxidation and anticancer activity

Yunli Xu ^{a, b} ,
Xuwen Da ^a ,
Lei Wang ^c ,
Yatong Peng ^{a, b} ,
Wanpeng Zhou ^{a, b} ,
Xiulian Liu ^{a, b} ,
Yao Wu ^{a, b} ,
Wentao Wang ^c ,
Xuesong Wang ^{a, b, *,} ,
Qianxiong Zhou ^{a, *,}

a.
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China

xswang@mail.ipc.ac.cn

zhouqianxiong@mail.ipc.ac.cn

Received Date: 22 April 2024
Revised Date: 20 June 2024
Accepted Date: 21 June 2024
Available Online: 22 June 2024

Figures(5)

Photodynamic therapy (PDT) has received much attention in recent years. However, traditional photosensitizers (PSs) applied in PDT usually suffer from aggregation-caused quenching (ACQ) effect in H₂O, single and inefficient photochemical mechanism of action (MoA), poor cancer targeting ability, etc. In this work, two novel Ru(Ⅱ)-based aggregation-induced emission (AIE) agents (Ru1 and Ru2) were developed. Both complexes exhibited long triplet excited lifetimes and nearly 100% singlet oxygen quantum yields in H₂O. In addition, Ru1 and Ru2 displayed potent photo-catalytic reduced nicotinamide adenine dinucleotide (NADH) oxidation activity with turnover frequency (TOF) values of about 1779 and 2000 h⁻¹, respectively. Therefore, both Ru1 and Ru2 showed efficient PDT activity towards a series of cancer cells. Moreover, Ru2 was further loaded in bovine serum albumin (BSA) to enhance the tumor targeting ability in vivo, and the obtained Ru2@BSA could selectively accumulate in tumor tissues and effectively inhibit tumor growth on a 4T1 tumor-bearing mouse model. So far as we know, this work represents the first report about Ru(Ⅱ) AIE agents that possess high singlet oxygen quantum yields and also potent photo-catalytic NADH oxidation activity, and may provide new ideas for rational design of novel PSs with efficient PDT activity.
- Ru(Ⅱ) complexes,
- Aggregation-induced emission,
- Photo-catalytic NADH oxidation,
- Photodynamic therapy,
- Turnover frequency
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沈阳化工大学材料科学与工程学院沈阳 110142

Ru(Ⅱ)-based aggregation-induced emission (AIE) agents with efficient 1O2 generation, photo-catalytic NADH oxidation and anticancer activity

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通讯作者: 陈斌, bchen63@163.com

Ru(Ⅱ)-based aggregation-induced emission (AIE) agents with efficient ¹O₂ generation, photo-catalytic NADH oxidation and anticancer activity