Citation: Jian Li, Jinjin Chen, Qi-Long Hu, Zhen Wang, Xiao-Feng Xiong. Recent progress of chemical methods for lysine site-selective modification of peptides and proteins[J]. Chinese Chemical Letters, ;2025, 36(5): 110126. doi: 10.1016/j.cclet.2024.110126 shu

Recent progress of chemical methods for lysine site-selective modification of peptides and proteins

Jian Li ^a ,
Jinjin Chen ^a ,
Qi-Long Hu ^b ,
Zhen Wang ^{a, c, d, *,} ,
Xiao-Feng Xiong ^{b, *,}

a.
School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, China
b.
State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
c.
The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
d.
Qinghai Provincial Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China

zhenw@lzu.edu.cn

xiongxf7@mail.sysu.edu.cn

Received Date: 19 April 2024
Revised Date: 12 June 2024
Accepted Date: 14 June 2024
Available Online: 14 June 2024

Figures(18)

Chemical modification of native peptides and proteins is a versatile strategy to facilitate late-stage diversification for functional studies. Among the proteogenic amino acids, lysine is extensively involved in post-translational modifications and the binding of ligands to target proteins, making its selective modification attractive. However, lysine’s high natural abundance and solvent accessibility, as well as its relatively low reactivity to cysteine, necessitate addressing chemoselectivity and regioselectivity for the Lys modification of native proteins. Although Lys chemoselective modification methods have been well developed, achieving site-selective modification of a specific Lys residue remains a great challenge. In this review, we discussed the challenges of Lys selective modification, presented recent examples of Lys chemoselective modification, and summarized the currently known methods and strategies for Lys site-selective modification. We also included an outlook on potential solutions for Lys site-selective labeling and its potential applications in chemical biology and drug development.
- Protein modification,
- Lysine,
- Site-selective modification,
- Antibody-drug conjugates,
- Peptide
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沈阳化工大学材料科学与工程学院沈阳 110142