Citation: Kai Ye, Zhicheng Ye, Chuantao Wang, Zhilai Luo, Cheng Lian, Chunyan Bao. Artificial signal transduction triggered by molecular photoisomerization in lipid membranes[J]. Chinese Chemical Letters, ;2025, 36(4): 110033. doi: 10.1016/j.cclet.2024.110033 shu

Artificial signal transduction triggered by molecular photoisomerization in lipid membranes

Kai Ye ^{a, 1} ,
Zhicheng Ye ^{a, 1} ,
Chuantao Wang ^a ,
Zhilai Luo ^a ,
Cheng Lian ^a ,
Chunyan Bao ^{a, b, *,}

a.
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China
b.
State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of pharmacy, East China University of Science and Technology, Shanghai 200237, China

baochunyan@ecust.edu.cn

Received Date: 22 February 2024
Revised Date: 16 May 2024
Accepted Date: 20 May 2024
Available Online: 21 May 2024

Figures(5)

Inspired by the light-dependent signal transduction in nature, we herein report a fully synthetic receptor AZO with the capacity of transmembrane signaling, working by photo-induced change of molecular conformation. Our receptor has an anchoring group, a rigid and photoresponsive transmembrane unit and a precatalyst tailgroup. After doping in lipid membranes, AZO is membrane anchored and the extended trans-isomer enables the tailgroup to bind with intravesicular Zn²⁺, thereby achieving enzyme activation and triggering downstream events (ester hydrolysis). However, the shortened cis-isomer pulls the tailgroup into lipids, thereby preventing the complexation and all transduction processes. Upon alternative irradiation of ultraviolet (UV) and visible light, the transduction process can be reversible switch between "ON" and "OFF", achieving light signal transduction. This study provides a new strategy for future design of artificial signal transduction receptors.
- Artificial signal transduction,
- Photoisomerization,
- Azobenzene,
- ON/OFF switch,
- Lipid membranes
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