Citation: Zhefei Hu, Jingwen Liao, Jiawen Zhou, Lulu Zhao, Yanjuan Liu, Yuefei Zhang, Wei Chen, Sheng Tang. A new green approach to synthesizing MIP-202@porous silica microspheres for positional isomer/enantiomer/hydrophilic separation[J]. Chinese Chemical Letters, ;2025, 36(1): 109985. doi: 10.1016/j.cclet.2024.109985 shu

A new green approach to synthesizing MIP-202@porous silica microspheres for positional isomer/enantiomer/hydrophilic separation

Zhefei Hu ^a ,
Jingwen Liao ^a ,
Jiawen Zhou ^a ,
Lulu Zhao ^a ,
Yanjuan Liu ^b ,
Yuefei Zhang ^a ,
Wei Chen ^a ,
Sheng Tang ^{a, *,}

a.
School of Chemistry and Environmental Engineering, Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan 430205, China
b.
School of Pharmacy, Linyi University, Linyi 276000, China

Received Date: 7 December 2023
Revised Date: 5 March 2024
Accepted Date: 1 April 2024
Available Online: 9 May 2024

Figures(4)

Metal-organic frameworks (MOFs) with superior physicochemical properties have great potential for applications in chromatographic separation. However, currently popular methods for the synthesis of MOF-based silica composite materials usually require the use of harmful organic solvents and long-term high-temperature sealing reactions. In order to respond to the needs of green chromatography, it is urgent to develop a new green organic-solvent-free strategy for the synthesis of MOF@SiO₂ composites. MIP-202 is a zirconium-MOF constructed from zirconium ion and l-aspartic acid, which features green synthesis as well as good hydrolytic stability and chemical stability. In this paper, SiO₂-NH₂ was first prepared in a hydrophilic deep eutectic solvent, and then an amino acid-based MOF material (MIP-202) was modified on the surface of the SiO₂-NH₂ in an aqueous solution to obtain a MIP-202@SiO₂ composite material. The multi-mode separation performance of MIP-202@SiO₂ as a promising liquid chromatographic stationary phase was particularly evaluated and the separation mechanisms were discussed. The MIP-202@SiO₂ column exhibited excellent separation ability for aromatic positional isomers. In addition, chiral enantiomers and hydrophilic analytes were also satisfactorily detected and separated. This work provides a new approach for the facile synthesis of MOF-based liquid chromatographic separation material by using green deep eutectic solvent and water as the reaction media.
- Metal-organic framework,
- Stationary phase,
- Deep eutectic solvent,
- Green chromatography,
- High-performance liquid chromatography
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