Citation: Yingjie Wang, Peng Tang, Wenchao Tu, Qi Gao, Cuizhu Wang, Luying Tan, Lixin Zhao, Hongye Han, Liefeng Ma, Kouharu Otsuki, Weilie Xiao, Wenli Wang, Jinping Liu, Yong Li, Zhajun Zhan, Wei Li, Xianli Zhou, Ning Li. Highly anticipated natural diterpenoids as an important source of new drugs in 2013–2023[J]. Chinese Chemical Letters, ;2025, 36(1): 109955. doi: 10.1016/j.cclet.2024.109955 shu

Highly anticipated natural diterpenoids as an important source of new drugs in 2013–2023

Yingjie Wang ^{a, 1} ,
Peng Tang ^{b, 1} ,
Wenchao Tu ^{b, 1} ,
Qi Gao ^{c, 1} ,
Cuizhu Wang ^{d, 1} ,
Luying Tan ^{d, 1} ,
Lixin Zhao ^{e, 1} ,
Hongye Han ^{e, 1} ,
Liefeng Ma ^{f, 1} ,
Kouharu Otsuki ^{g, 1} ,
Weilie Xiao ^{b, *,} ,
Wenli Wang ^{c, *,} ,
Jinping Liu ^{d, *,} ,
Yong Li ^{e, *,} ,
Zhajun Zhan ^{f, *,} ,
Wei Li ^{g, *,} ,
Xianli Zhou ^{h, *,} ,
Ning Li ^{a, *,}

a.
School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Yunnan Key Laboratory of Research and Development for Natural Products; School of Pharmacy and School of Chemical Science and Technology, State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, China
c.
School of Pharmacy, Nantong University, Nantong 226001, China
d.
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China
e.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
f.
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
g.
Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan
h.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

xiaoweilie@ynu.edu.cn

liwei@phar.toho-u.ac.jp

zhouxl@swjtu.edu.cn

liningsypharm@163.com

Received Date: 11 March 2024
Revised Date: 26 April 2024
Accepted Date: 29 April 2024
Available Online: 1 May 2024

Figures(17)

This review covers the structures of diterpenoids, including chain (72), monocyclic (9), labdane-type (67), clerodane-type (127) abietane-type (716), ent-kaurane-type (89), grayanane-type (331), ingenane-type (55), tigliane-type (154), daphnane-type (237), and aconitine-type diterpene alkaloids (265) with rich biological activities reported in 2013–2023. And the drugs in clinical use or under clinical investigation of diterpenoids and leading compounds were summarized.
- Natural diterpenoids,
- Structures,
- Bioactivities,
- Druggability,
- Leading compounds,
- New drugs
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