Citation: Yunyan Li, Zimin Cai, Zhicheng Wang, Sifeng Zhu, Wendian Liu, Cheng Wang. Construction of biomimetic hybrid nanovesicles based on M1 macrophage-derived exosomes for therapy of cancer[J]. Chinese Chemical Letters, ;2025, 36(4): 109942. doi: 10.1016/j.cclet.2024.109942 shu

Construction of biomimetic hybrid nanovesicles based on M1 macrophage-derived exosomes for therapy of cancer

Yunyan Li ^a ,
Zimin Cai ^a ,
Zhicheng Wang ^a ,
Sifeng Zhu ^a ,
Wendian Liu ^a ,
Cheng Wang ^{a, b, *,}

a.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
b.
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China

cheng13980029671@163.com

Received Date: 20 February 2024
Revised Date: 24 April 2024
Accepted Date: 28 April 2024
Available Online: 29 April 2024

Figures(5)

Established evidence has unveiled two strategies for treating cancer: depleting tumor-associated macrophages (TAMs) and reprogramming M2-like TAMs into an antitumor M1 phenotype. Here, we designed novel pH-sensitive biomimetic hybrid nanovesicles (EDHPA) loaded with doxorubicin (DOX). DOX@EDHPA can specifically target TAMs by activating macrophage-derived exosomes (M1-Exos) and anisamide (AA) as cancer-specific targeting ligands. In vitro and in vivo studies demonstrated that DOX@EDHPA could efficiently be delivered to the tumor site and taken up by cells. Meanwhile, it synergistically enhanced immunogenic cell death (ICD) and induced a subsequent antigen-specific T cell immune response. The tumor inhibitory rate of the DOX@EDHPA group was 1.42 times that of the free DOX group. Further analysis showed that the excellent antitumor effects of DOX@EDHPA should ascribe to the homing effect of M1-Exos on macrophages and the repolarization to antitumor M1 TAMs, which induced the elevated secretion of pro-inflammatory factors. Therefore, the hybrid EDHPA targeting TAMs to reshape the tumor microenvironment constituted a novel immunochemotherapy strategy to inhibit tumor growth.
- Tumor-associated macrophages,
- M1-Exos,
- Hybrid nanovesicles,
- Immunogenic cell death,
- Immunochemotherapy
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沈阳化工大学材料科学与工程学院沈阳 110142