Citation: Qi Huang, Jun Liao, Jingjing Li, Zhengyan Gu, Xinkang Zhang, Mingxue Sun, Wenqi Meng, Guanchao Mao, Zhipeng Pei, Shanshan Zhang, Songling Li, Chuan Zhang, Yunqin Wang, Jihao Liu, Tingbin Shu, Min Tao, Ying Lu, Kai Xiao, Qingqiang Xu, Jincai Lu. Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury[J]. Chinese Chemical Letters, ;2025, 36(4): 109914. doi: 10.1016/j.cclet.2024.109914 shu

Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury

Qi Huang ^{a, b, 1} ,
Jun Liao ^{c, d, e, 1} ,
Jingjing Li ^{a, b, 1} ,
Zhengyan Gu ^{b, d, 1} ,
Xinkang Zhang ^b ,
Mingxue Sun ^b ,
Wenqi Meng ^b ,
Guanchao Mao ^b ,
Zhipeng Pei ^b ,
Shanshan Zhang ^b ,
Songling Li ^b ,
Chuan Zhang ^e ,
Yunqin Wang ^b ,
Jihao Liu ^b ,
Tingbin Shu ^b ,
Min Tao ^b ,
Ying Lu ^{d, *,} ,
Kai Xiao ^{b, f, *,} ,
Qingqiang Xu ^{b, g, *,} ,
Jincai Lu ^{a, *,}

a.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
c.
School of Basic Medical Sciences, Peking University, Beijing 100191, China
d.
Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
e.
School of Medicine, Shanghai University, Shanghai 200444, China
f.
Marine Biomedical Science and Technology Innovation Platform of Lingang Special Area, Shanghai 201306, China
g.
Basic Medical Center for Pulmonary Disease, Naval Medical University, Shanghai 200433, China

acuace@163.com

kaixiaocn@163.com

xuqingqiang1027@126.com

jincailu@syphu.edu.cn

Received Date: 26 February 2024
Revised Date: 15 April 2024
Accepted Date: 21 April 2024
Available Online: 22 April 2024

Figures(4)

Acute lung injury (ALI) is a critical respiratory disorder with a high mortality rate and is caused by several factors. Addressing oxidative stress and inflammation is a pivotal strategy for ALI treatment. In this study, we introduced a novel nanotherapeutic approach involving a curcumin-loaded ceria nanoenzyme delivery system tailored to counteract the multifaceted aspects of ALI. This system leverages the individual and combined effects of the components to provide a comprehensive therapeutic solution. The dual-action capability of this nanosystem was manifested by mitigating mitochondrial oxidative stress in lung epithelial cells and inhibiting the transient receptor potential melanosome-associated protein 2 (TRPM2)-NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, offering a highly effective therapeutic approach to ALI. Our findings reveal the underlying mechanisms of this innovative nanodelivery system, showcasing its potential as a versatile strategy for ALI treatment and encouraging further exploration of nanoenzyme-based therapies for ALI.
- Ceria nanoenzymes,
- Curcumin,
- Acute lung injury,
- Oxidative damage,
- Inflammation,
- Nano delivery systems
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