Citation: Qi Huang, Jun Liao, Jingjing Li, Zhengyan Gu, Xinkang Zhang, Mingxue Sun, Wenqi Meng, Guanchao Mao, Zhipeng Pei, Shanshan Zhang, Songling Li, Chuan Zhang, Yunqin Wang, Jihao Liu, Tingbin Shu, Min Tao, Ying Lu, Kai Xiao, Qingqiang Xu, Jincai Lu. Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury[J]. Chinese Chemical Letters, ;2025, 36(4): 109914. doi: 10.1016/j.cclet.2024.109914 shu

Curcumin-loaded ceria nanoenzymes for dual-action suppression of inflammation and alleviation of oxidative damage in the treatment of acute lung injury

Qi Huang ^{a, b, 1} ,
Jun Liao ^{c, d, e, 1} ,
Jingjing Li ^{a, b, 1} ,
Zhengyan Gu ^{b, d, 1} ,
Xinkang Zhang ^b ,
Mingxue Sun ^b ,
Wenqi Meng ^b ,
Guanchao Mao ^b ,
Zhipeng Pei ^b ,
Shanshan Zhang ^b ,
Songling Li ^b ,
Chuan Zhang ^e ,
Yunqin Wang ^b ,
Jihao Liu ^b ,
Tingbin Shu ^b ,
Min Tao ^b ,
Ying Lu ^{d, *,} ,
Kai Xiao ^{b, f, *,} ,
Qingqiang Xu ^{b, g, *,} ,
Jincai Lu ^{a, *,}

a.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
b.
Lab of Toxicology and Pharmacology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China
c.
School of Basic Medical Sciences, Peking University, Beijing 100191, China
d.
Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China
e.
School of Medicine, Shanghai University, Shanghai 200444, China
f.
Marine Biomedical Science and Technology Innovation Platform of Lingang Special Area, Shanghai 201306, China
g.
Basic Medical Center for Pulmonary Disease, Naval Medical University, Shanghai 200433, China

acuace@163.com

kaixiaocn@163.com

xuqingqiang1027@126.com

jincailu@syphu.edu.cn

Received Date: 26 February 2024
Revised Date: 15 April 2024
Accepted Date: 21 April 2024
Available Online: 22 April 2024

Figures(4)

Acute lung injury (ALI) is a critical respiratory disorder with a high mortality rate and is caused by several factors. Addressing oxidative stress and inflammation is a pivotal strategy for ALI treatment. In this study, we introduced a novel nanotherapeutic approach involving a curcumin-loaded ceria nanoenzyme delivery system tailored to counteract the multifaceted aspects of ALI. This system leverages the individual and combined effects of the components to provide a comprehensive therapeutic solution. The dual-action capability of this nanosystem was manifested by mitigating mitochondrial oxidative stress in lung epithelial cells and inhibiting the transient receptor potential melanosome-associated protein 2 (TRPM2)-NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, offering a highly effective therapeutic approach to ALI. Our findings reveal the underlying mechanisms of this innovative nanodelivery system, showcasing its potential as a versatile strategy for ALI treatment and encouraging further exploration of nanoenzyme-based therapies for ALI.
- Ceria nanoenzymes,
- Curcumin,
- Acute lung injury,
- Oxidative damage,
- Inflammation,
- Nano delivery systems
1. [1]
  S.R. Leist, K.H. Dinnon, A. Schäfer, et al., Cell 183 (2020) 1070–1085.
2. [2]
  W. Zhong, X. Zhang, Y. Zeng, et al., Nano Res. 14 (2021) 2067–2089. doi: 10.1007/s12274-020-3180-3
3. [3]
  Y. Wang, Q. Li, M. Deng, et al., Chin. Chem. Lett. 33 (2022) 324–327. doi: 10.1016/j.cclet.2021.06.080
4. [4]
  H. Wu, F. Li, S. Wang, et al., Biomaterials 151 (2018) 66–77. doi: 10.1002/sam.11370
5. [5]
  C. Zhuang, M. Kang, M. Lee, J. Control. Release 360 (2023) 1–14.
6. [6]
  Y. Li, J. Liao, L. Xiong, et al., J. Control. Release 368 (2024) 607–622.
7. [7]
  C. Liu, J. Yao, J. Hu, et al., Mater. Horiz. 7 (2020) 3176–3186. doi: 10.1039/d0mh01225d
8. [8]
  Y. Meng, S. Han, J. Yin, J. Wu, ACS Appl. Mater. Interfaces 15 (2023) 41743–41754. doi: 10.1021/acsami.3c08608
9. [9]
  C. Liu, W. Fan, W.X. Cheng, et al., Adv. Funct. Mater. 33 (2023) 2213856.
10. [10]
  J. Liao, Y. Li, L. Fan, et al., ACS Nano 18 (2024) 5510–5529.
11. [11]
  C. Liu, J. Xing, O.U. Akakuru, et al., Nano Lett. 19 (2019) 5674–5682. doi: 10.1021/acs.nanolett.9b02253
12. [12]
  C. Liu, L. Luo, L. Zeng, et al., Small 14 (2018) 1801851.
13. [13]
  J. Liu, D. He, T. Hao, et al., Chin. Chem. Lett. 35 (2024) 109296. doi: 10.1016/j.cclet.2023.109296
14. [14]
  Z. Wu, H. Wang, S. Fang, C. Xu, Mol. Med. Rep. 18 (2018) 4163–4174.
15. [15]
  Y. Wang, H. Dong, H. Qu, et al., Nano Lett. 24 (2024) 2131–2141. doi: 10.1021/acs.nanolett.3c03671
16. [16]
  F. Zeng, Y. Wu, X. Li, et al., Angew. Chem. Int. Ed. 57 (2018) 5808–5812. doi: 10.1002/anie.201802309
17. [17]
  J. Liao, Y. Li, Y. Luo, et al., Mol. Pharm. 19 (2022) 3026–3041. doi: 10.1021/acs.molpharmaceut.2c00383
18. [18]
  J. Liao, L. Fan, Y. Li, et al., J. Control. Release 358 (2023) 439–464.
19. [19]
  C. Xie, J. Liao, N. Zhang, et al., Chin. Chem. Lett. 35 (2024) 109149. doi: 10.1016/j.cclet.2023.109149
20. [20]
  R. Yuan, Y. Li, S. Han, et al., ACS Cent. Sci. 8 (2021) 10–21. doi: 10.15302/j-laf-1-010013
21. [21]
  H. He, L. Du, H. Xue, et al., Small Methods 7 (2023) 2300230.
22. [22]
  L. Sun, Y. Liu, X. Liu, et al., Adv. Sci. 9 (2022) 2104051.
23. [23]
  C. Liu, L. Xi, Y. Liu, et al., ACS Nano 17 (2023) 11626–11644. doi: 10.1021/acsnano.3c02075
24. [24]
  A. Unlu, E. Nayir, M. Dogukan Kalenderoglu, et al., J. BUON 21 (2016) 1050–1060.
25. [25]
  J. Gao, Z. Weng, Z. Zhang, et al., Adv. Healthc. Mater. 13 (2024) 2303095. doi: 10.1002/adhm.202303095
26. [26]
  A. Farazin, M. Mohammadimehr, A.H. Ghasemi, H. Naeimi, RSC Adv. 11 (2021) 32775–32791.
27. [27]
  H. Wei, D. Jiang, B. Yu, et al., Bioact. Mater. 19 (2023) 282–291.
28. [28]
  N.J. Himmel, D.N. Cox, Proc. Biol. Soc. 287 (2020) 20201309.
29. [29]
  E. Jäger, S. Murthy, C. Schmidt, et al., Nat. Commun. 11 (2020) 4243.
30. [30]
  K. Wang, Q. Sun, X. Zhong, et al., Cell 180 (2020) 941–955.
31. [31]
  L. Meng, X. Zhao, H. Zhang, Med. Sci. Monit. 25 (2019) 827–835. doi: 10.12659/msm.912507
32. [32]
  F.J. Bock, S.W.G. Tait, Nat. Rev. Mol. Cell Biol. 21 (2020) 85–100. doi: 10.1038/s41580-019-0173-8
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  Haijiao Li , Mingzu Zhang , Jinlin He , Jian Liu , Xingwei Sun , Peihong Ni . Synthesis of curcumin polyprodrug via click chemistry and construction of dual-drug-loaded nano platform for highly efficient tumor treatment. Chinese Chemical Letters, 2025, 36(8): 110615-. doi: 10.1016/j.cclet.2024.110615
2. [2]
  Ying Xu , Chengying Shen , Hailong Yuan , Wei Wu . Mapping multiple phases in curcumin binary solid dispersions by fluorescence contrasting. Chinese Chemical Letters, 2024, 35(9): 109324-. doi: 10.1016/j.cclet.2023.109324
3. [3]
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4. [4]
  Dandan Tang , Ningge Xu , Yuyang Fu , Wei Peng , Jinsheng Wu , Heng Liu , Fabiao Yu . Rationally designed an innovative proximity labeling near-infrared fluorogenic probe for imaging of peroxynitrite in acute lung injury. Chinese Chemical Letters, 2025, 36(5): 110082-. doi: 10.1016/j.cclet.2024.110082
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  Ruimiao Chang , Xinying Qu , Yuting Ye , Ying Qu , Bingyang Chu , Zhiyong Qian . Current advances in nanomedicine-based therapies for acute kidney injury. Chinese Chemical Letters, 2025, 36(10): 110802-. doi: 10.1016/j.cclet.2024.110802
6. [6]
  Yingtao Zhong , Ziwen Qiu , Yanmei Li , Jiaqi Huang , Zhenming Lu , Renjiang Kong , Ni Yan , Hong Cheng . Nutrients deprivation of biomimetic nanozymes for cascade catalysis triggered and oxidative damage induced tumor eradication. Chinese Chemical Letters, 2025, 36(3): 109846-. doi: 10.1016/j.cclet.2024.109846
7. [7]
  Xiaoyi Meng , Xinyue Sun , Zhaogang Sun , Yue Cheng , Yong Wang , Jun Ye , Yin Xiao , Hongqian Chu . Supramolecular-orchestrated carrier-free chemodynamic synergists with augmented oxidative damage for potentiated cancer therapy. Chinese Chemical Letters, 2025, 36(5): 110765-. doi: 10.1016/j.cclet.2024.110765
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10. [10]
  Yang Li , Ning Sheng , Kun Wang , Yuhuan Li , Jiandong Jiang , Jinlan Zhang . Azvudine alleviates SARS-CoV-2-induced inflammation by targeting myeloperoxidase in NETosis. Chinese Chemical Letters, 2025, 36(5): 110238-. doi: 10.1016/j.cclet.2024.110238
11. [11]
  Gaowa Xing , Yuxuan Li , Hongren Yao , Qiang Zhang , Zengnan Wu , Caihou Lin , Jin-Ming Lin . Tryptophan accumulation and inflammation of glioblastoma cells in a multicomponent microchip for gut-brain-axis simulation. Chinese Chemical Letters, 2025, 36(12): 111035-. doi: 10.1016/j.cclet.2025.111035
12. [12]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
13. [13]
  Feifei Wang , Hang Yao , Xinyue Wu , Yijian Tang , Yang Bai , Hui Chong , Huan Pang . Metal–organic framework and its composites modulate macrophage polarization in the treatment of inflammatory diseases. Chinese Chemical Letters, 2024, 35(5): 108821-. doi: 10.1016/j.cclet.2023.108821
14. [14]
  Xianzhu Luo , Feifei Yu , Rui Wang , Tian Su , Pan Luo , Pengfei Wen , Fabiao Yu . A near-infrared two-photon fluorescent probe for the detection of HClO in inflammatory and tumor-bearing mice. Chinese Chemical Letters, 2025, 36(7): 110531-. doi: 10.1016/j.cclet.2024.110531
15. [15]
  Yikun Chen , Wenling Li , Juan Cao , Yongjun Wang , Yufang Guo , Liu Qing , Li Wang , Sisi Yu , Lei Xing , Hulin Jiang , Bing Wan . Break the vicious cycle and remodel the malignant inflammatory microenvironment in ARDS with efferocytosis-informed nanodrugs. Chinese Chemical Letters, 2026, 37(7): 111722-. doi: 10.1016/j.cclet.2025.111722
16. [16]
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17. [17]
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19. [19]
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