Citation: Ze Wang, Hao Liang, Annan Liu, Xingchen Li, Lin Guan, Lei Li, Liang He, Andrew K. Whittaker, Bai Yang, Quan Lin. Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer[J]. Chinese Chemical Letters, ;2025, 36(2): 109765. doi: 10.1016/j.cclet.2024.109765 shu

Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer

Ze Wang ^a ,
Hao Liang ^a ,
Annan Liu ^a ,
Xingchen Li ^a ,
Lin Guan ^a ,
Lei Li ^b ,
Liang He ^{c, *,} ,
Andrew K. Whittaker ^d ,
Bai Yang ^a ,
Quan Lin ^{a, *,}

a.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China
b.
Department of Endocrinology, Lequn Branch, the First Hospital of Jilin University, Changchun 130021, China
c.
Department of Urology, the First Hospital of Jilin University, Changchun 130021, China
d.
Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, QLD 4072, Australia

lianghe9278@jlu.edu.cn

linquan@jlu.edu.cn

Received Date: 11 January 2024
Revised Date: 9 March 2024
Accepted Date: 12 March 2024
Available Online: 12 March 2024

Figures(5)

Prostate cancer (PCa) is characterized by high incidence and propensity for easy metastasis, presenting significant challenges in clinical diagnosis and treatment. Tumor microenvironment (TME)-responsive nanomaterials provide a promising prospect for imaging-guided precision therapy. Considering that tumor-derived alkaline phosphatase (ALP) is over-expressed in metastatic PCa, it makes a great chance to develop a theranostics system with ALP responsive in the TME. Herein, an ALP-responsive aggregation-induced emission luminogens (AIEgens) nanoprobe AMNF self-assembly was designed for enhancing the diagnosis and treatment of metastatic PCa. The nanoprobe exhibited self-aggregation in the presence of ALP resulted in aggregation-induced fluorescence, and enhanced accumulation and prolonged retention period at the tumor site. In terms of detection, the fluorescence (FL)/computed tomography (CT)/magnetic resonance (MR) multi-mode imaging effect of nanoprobe was significantly improved post-aggregation, enabling precise diagnosis through the amalgamation of multiple imaging modes. Enhanced CT/MR imaging can achieve assist preoperative tumor diagnosis, and enhanced FL imaging technology can achieve "intraoperative visual navigation", showing its potential application value in clinical tumor detection and surgical guidance. In terms of treatment, AMNF showed strong absorption in the near infrared region after aggregation, which improved the photothermal treatment effect. Overall, our work developed an effective aggregation-enhanced theranostic strategy for ALP-related cancers.
- AIE,
- Prostate cancer,
- ALP responsive,
- Enhanced multi-mode imaging,
- Enhanced photothermal therapy
1. [1]
  B.S. Wang, S.D. Zhang, J.X. Meng, et al., Adv. Mater. 33 (2021) 2103999. doi: 10.1002/adma.202103999
2. [2]
  Z.H. Ding, C.J. Wu, G.C. Chu, et al., Nature 470 (2011) 269–273. doi: 10.1038/nature09677
3. [3]
  T.T. Wheeler, P. Cao, M.D. Ghouri, et al., Sci. China Chem. 65 (2022) 1498–1514. doi: 10.1007/s11426-022-1271-0
4. [4]
  Z. Wang, A.N. Liu, X.C. Li, et al., Talanta 256 (2023) 124255. doi: 10.1016/j.talanta.2023.124255
5. [5]
  Z.M. Wang, L.N. Chen, C.S. Huang, Y.K. Huang, N.Q. Jia, J. Mater. Chem. B 5 (2017) 3498–3510. doi: 10.1039/C7TB00561J
6. [6]
  Y.L. Lin, Y.Q. Zhao, Z. Yang, et al., Talanta 241 (2022) 123241. doi: 10.1016/j.talanta.2022.123241
7. [7]
  A.D. Salaam, P.T.J. Hwang, A. Poonawalla, et al., Nanotechnology 25 (2014) 425103. doi: 10.1088/0957-4484/25/42/425103
8. [8]
  K.X. Huang, B. Shi, W.G. Xu, et al., Acta Biomater. 27 (2015) 179–193. doi: 10.1016/j.actbio.2015.08.049
9. [9]
  P. Armanetti, A. Chilla, F. Margheri, et al., Adv. Sci. 8 (2021) 2001175. doi: 10.1002/advs.202001175
10. [10]
  J.W. Wang, J.J. Fu, H. Chen, et al., Biosens. Bioelectron. 224 (2023) 115051. doi: 10.1016/j.bios.2022.115051
11. [11]
  L.A. Austin, B. Kang, M.A. El-Sayed, Nano Today 10 (2015) 542–558. doi: 10.1016/j.nantod.2015.07.005
12. [12]
  Y.X. Liu, M.D. Cao, Z.X. Huang, et al., Chin. Chem. Lett. 33 (2022) 1855–1860. doi: 10.1016/j.cclet.2021.08.117
13. [13]
  J.Y. Zhu, A. Ouyang, Z.L. Shen, et al., Chin. Chem. Lett. 33 (2022) 1907–1912. doi: 10.1016/j.cclet.2021.11.017
14. [14]
  M.Z. Lv, M.X. Chen, R. Zhang, et al., Cell Res. 30 (2020) 966–979. doi: 10.1038/s41422-020-00395-4
15. [15]
  X.H. Lin, R. Zhu, Z.Z. Hong, et al., Adv. Funct. Mater. 31 (2021) 2101278. doi: 10.1002/adfm.202101278
16. [16]
  D. Huo, S. Liu, C. Zhang, et al., ACS Nano 11 (2017) 10159–10174. doi: 10.1021/acsnano.7b04737
17. [17]
  E.M. Higbee-Dempsey, A. Amirshaghaghi, M.J. Case, et al., J. Am. Chem. Soc. 142 (2020) 7783–7794. doi: 10.1021/jacs.9b13813
18. [18]
  Z. Wang, D.Z. Wang, X.J. Ren, et al., ACS Cent. Sci. 9 (2023) 1976–1988. doi: 10.1021/acscentsci.3c00994
19. [19]
  F. Danhier, J. Control Release 244 (2016) 108–121. doi: 10.1016/j.jconrel.2016.11.015
20. [20]
  D.Y. Liu, L.Y. Liu, F.Y. Liu, et al., Adv. Sci. 8 (2021) 2100074. doi: 10.1002/advs.202100074
21. [21]
  R.R. Wang, N.N. Zhao, F.J. Xu, Adv. Funct. Mater. 27 (2017) 1700256. doi: 10.1002/adfm.201700256
22. [22]
  Q.L. Mao, J. Fang, A.N. Wang, et al., Angew. Chem. Int. Ed. 60 (2021) 23805–23811. doi: 10.1002/anie.202109863
23. [23]
  M.Q. Liu, M. Yang, X.Z. Wan, et al., Adv. Mater. 35 (2023) 2208995. doi: 10.1002/adma.202208995
24. [24]
  J.L. Shen, B. Situ, X.C. Du, et al., ACS Sens. 7 (2022) 766–774. doi: 10.1021/acssensors.1c02237
25. [25]
  Y.Y. Yuan, C.J. Zhang, M. Gao, et al., Angew. Chem. Int. Ed. 54 (2015) 1780–1786. doi: 10.1002/anie.201408476
26. [26]
  Y.Q. Xu, M.Y. Cui, W.C. Zhang, et al., Chem. Eng. J. 428 (2022) 132514. doi: 10.1016/j.cej.2021.132514
27. [27]
  C.F. Wu, R. Zhang, W. Du, L. Cheng, G.L. Liang, Nano Lett. 18 (2018) 7749–7754. doi: 10.1021/acs.nanolett.8b03482
28. [28]
  D.F. Yao, S.Y. Yang, Y.S. Wang, et al., Nanoscale 11 (2019) 6307–6314. doi: 10.1039/c9nr00913b
29. [29]
  J.Z. Liu, H.M. Meng, L. Zhang, et al., Chin. Chem. Lett. 32 (2021) 3421–3425. doi: 10.1016/j.cclet.2021.05.019
30. [30]
  Z. Feng, H. Wang, X. Chen, B. Xu, J. Am. Chem. Soc. 139 (2017) 15377–15384. doi: 10.1021/jacs.7b07147
31. [31]
  S.Y. Yang, D.F. Yao, Y.S. Wang, et al., Chem. Commun. 54 (2018) 9841–9844. doi: 10.1039/c8cc05136d
32. [32]
  R.C. Guo, X.H. Zhang, P.S. Fan, et al., Angew. Chem. Int. Ed. 60 (2021) 25128–25134. doi: 10.1002/anie.202111839
33. [33]
  Z. Wang, X.L. Ou, L. Guan, et al., Biosens. Bioelectron. 235 (2023) 115386. doi: 10.1016/j.bios.2023.115386
34. [34]
  Z. Wang, H.Y. Xing, A.N. Liu, et al., Acta Biomater. 166 (2023) 581–592. doi: 10.1016/j.actbio.2023.05.014
35. [35]
  Z. Zhao, H.K. Zhang, J.W.Y. Lam, B.Z. Tang, Angew. Chem. Int. Ed. 59 (2020) 9888–9907. doi: 10.1002/anie.201916729
36. [36]
  S. Suzuki, S. Sasaki, A.S. Sairi, et al., Angew. Chem. Int. Ed. 59 (2020) 9856–9867. doi: 10.1002/anie.202000940
37. [37]
  B.N. Wang, L.R. Wang, H.Z. Wu, et al., Bioact. Mater. 23 (2023) 223–233. doi: 10.1080/11956860.2024.2303187
38. [38]
  H.L. Zhao, N. Li, C.X. Ma, et al., Chin. Chem. Lett. 34 (2023) 107699. doi: 10.1016/j.cclet.2022.07.042
1. [1]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
2. [2]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
3. [3]
  Xing Tian , Di Wu , Wanheng Wei , Guifu Dai , Zhanxian Li , Benhua Wang , Mingming Yu . A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue. Chinese Chemical Letters, 2024, 35(6): 108912-. doi: 10.1016/j.cclet.2023.108912
4. [4]
  Ya-Ping Liu , Zhi-Rong Gui , Zhen-Wen Zhang , Sai-Kang Wang , Wei Lang , Yanzhu Liu , Qian-Yong Cao . A phenylphenthiazide anchored Tb(Ⅲ)-cyclen complex for fluorescent turn-on sensing of ClO⁻. Chinese Chemical Letters, 2025, 36(2): 109769-. doi: 10.1016/j.cclet.2024.109769
5. [5]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
6. [6]
  Xuejian Xing , Pan Zhu , E Pang , Shaojing Zhao , Yu Tang , Zheyu Hu , Quchang Ouyang , Minhuan Lan . D-A-D-structured boron-dipyrromethene with aggregation-induced enhanced phototherapeutic efficiency for near-infrared fluorescent and photoacoustic imaging-guided synergistic photodynamic and photothermal cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109452-. doi: 10.1016/j.cclet.2023.109452
7. [7]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
8. [8]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
9. [9]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
10. [10]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
11. [11]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
12. [12]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
13. [13]
  Jianye Kang , Xinyu Yang , Xuhao Yang , Jiahui Sun , Yuhang Liu , Shutao Wang , Wenlong Song . Carbon dots-enhanced pH-responsive lubricating hydrogel based on reversible dynamic covalent bondings. Chinese Chemical Letters, 2024, 35(5): 109297-. doi: 10.1016/j.cclet.2023.109297
14. [14]
  Haijing Cui , Weihao Zhu , Chuning Yue , Ming Yang , Wenzhi Ren , Aiguo Wu . Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment. Chinese Chemical Letters, 2024, 35(10): 109727-. doi: 10.1016/j.cclet.2024.109727
15. [15]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895
16. [16]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
17. [17]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
18. [18]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
19. [19]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
20. [20]
  Xiaoshuai Wu , Bailei Wang , Yichen Li , Xiaoxuan Guan , Mingjing Yin , Wenquan Lv , Yin Chen , Fei Lu , Tao Qin , Huyang Gao , Weiqian Jin , Yifu Huang , Cuiping Li , Ming Gao , Junyu Lu . NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS. Chinese Chemical Letters, 2025, 36(2): 110211-. doi: 10.1016/j.cclet.2024.110211

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(36)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142