Citation: Haijing Cui, Weihao Zhu, Chuning Yue, Ming Yang, Wenzhi Ren, Aiguo Wu. Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment[J]. Chinese Chemical Letters, ;2024, 35(10): 109727. doi: 10.1016/j.cclet.2024.109727 shu

Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment

Haijing Cui ^{a, b, 1} ,
Weihao Zhu ^{a, b, 1} ,
Chuning Yue ^{a, b} ,
Ming Yang ^b ,
Wenzhi Ren ^{a, b, c, *,} ,
Aiguo Wu ^{b, c, *,}

a.
Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo 315300, China
b.
Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China
c.
Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, China

renwzh@nimte.ac.cn

aiguo@nimte.ac.cn

Received Date: 27 December 2023
Revised Date: 23 February 2024
Accepted Date: 25 February 2024
Available Online: 7 March 2024

Figures(5)

Sonodynamic therapy (SDT) exhibits promising clinical applications in cancer treatment owing to its advantages, including ultrasonic cavitation effect, mechanical effect, and deep tissue penetration. Titanium dioxide (TiO₂) nanomaterials, recognized as excellent sonosensitizers, have been extensively studied in cancer SDT. This review first outlines the mechanism of TiO₂-based SDT, then systematically discusses the regulation of TiO₂ sonosensitivity, covering aspects such as morphology, particle size, element doping, defect engineering, heterojunction structure, and interactions with the tumor microenvironment. Furthermore, the review generalizes ultrasound-responsive TiO₂-based therapeutic modalities for tumor treatment, including SDT, SDT combined with chemotherapy, chemodynamic therapy, photothermal therapy, immunotherapy, and treatment visualization. Finally, the review navigates the ongoing challenges and prospects in TiO₂-based cancer SDT.
- Titanium dioxide,
- Sonodynamic therapy,
- Reactive oxygen species,
- Cavitation effects,
- Combined therapy
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沈阳化工大学材料科学与工程学院沈阳 110142