Citation: Xu Luo, Jinwen Xiao, Qiming Yang, Xiaolong Lu, Qianjun Huang, Xiaojun Ai, Bo Li, Li Sun, Long Chen. Biomaterials for surgical repair of osteoporotic bone defects[J]. Chinese Chemical Letters, ;2025, 36(1): 109684. doi: 10.1016/j.cclet.2024.109684 shu

Biomaterials for surgical repair of osteoporotic bone defects

Xu Luo ^{a, b, 1} ,
Jinwen Xiao ^{a, b, c, 1} ,
Qiming Yang ^{a, b, 1} ,
Xiaolong Lu ^{a, c} ,
Qianjun Huang ^{a, c} ,
Xiaojun Ai ^{a, c} ,
Bo Li ^{a, b, *,} ,
Li Sun ^{a, b, c, *,} ,
Long Chen ^{a, b, c, *,}

a.
Department of Orthopedics, Guizhou Provincial People’s Hospital, Guiyang 550000, China
b.
Medical College, Guizhou University, Guiyang 550000, China
c.
Graduate School, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China

libo8588@hotmail.com

lisun@gzu.edu.cn

longchen@gzu.edu.cn

Received Date: 25 December 2023
Revised Date: 25 February 2024
Accepted Date: 26 February 2024
Available Online: 2 March 2024

As the global population ages, osteoporotic bone fractures leading to bone defects are increasingly becoming a significant challenge in the field of public health. Treating this disease faces many challenges, especially in the context of an imbalance between osteoblast and osteoclast activities. Therefore, the development of new biomaterials has become the key. This article reviews various design strategies and their advantages and disadvantages for biomaterials aimed at osteoporotic bone defects. Overall, current research progress indicates that innovative design, functionalization, and targeting of materials can significantly enhance bone regeneration under osteoporotic conditions. By comprehensively considering biocompatibility, mechanical properties, and bioactivity, these biomaterials can be further optimized, offering a range of choices and strategies for the repair of osteoporotic bone defects.
- Osteoporotic bone defect,
- Biomaterials,
- Nanomaterials,
- Bone tissue engineering,
- Bone regeneration
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沈阳化工大学材料科学与工程学院沈阳 110142