Citation: Yi Luo, Lin Dong. Multicomponent remote C(sp²)-H bond addition by Ru catalysis: An efficient access to the alkylarylation of 2H-imidazoles[J]. Chinese Chemical Letters, ;2024, 35(10): 109648. doi: 10.1016/j.cclet.2024.109648 shu

Multicomponent remote C(sp²)-H bond addition by Ru catalysis: An efficient access to the alkylarylation of 2H-imidazoles

Yi Luo ,
Lin Dong ^*,

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

dongl@scu.edu.cn

Received Date: 22 November 2023
Revised Date: 25 January 2024
Accepted Date: 4 February 2024
Available Online: 10 February 2024

Figures(6)

Sequential C-H bond addition with two different coupling partners is a powerful method for the rapid and modular construction of complex molecules based on simple starting materials. Herein, an efficient ruthenium-catalysed multicomponent long-range C-H functionalization of 2H-imidazoles was developed. This protocol showed good substrate suitability and yielded alkyl arylation products with potential biological activity.
- Remote C-H functionalization,
- Multi-component reaction,
- Ruthenium catalysis,
- 2H-Imidazoles
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沈阳化工大学材料科学与工程学院沈阳 110142

Multicomponent remote C(sp2)-H bond addition by Ru catalysis: An efficient access to the alkylarylation of 2H-imidazoles

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通讯作者: 陈斌, bchen63@163.com

Multicomponent remote C(sp²)-H bond addition by Ru catalysis: An efficient access to the alkylarylation of 2H-imidazoles