Citation: Qinyu Zhao, Yunchao Zhao, Songjing Zhong, Zhaoyang Yue, Zhuoheng Jiang, Shaobo Wang, Quanhong Hu, Shuncheng Yao, Kaikai Wen, Linlin Li. Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy[J]. Chinese Chemical Letters, ;2024, 35(12): 109644. doi: 10.1016/j.cclet.2024.109644 shu

Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy

Qinyu Zhao ^{a, b, 1} ,
Yunchao Zhao ^{d, b, 1} ,
Songjing Zhong ^{b, c} ,
Zhaoyang Yue ^{a, b} ,
Zhuoheng Jiang ^{b, c} ,
Shaobo Wang ^{a, b} ,
Quanhong Hu ^{a, b} ,
Shuncheng Yao ^{b, c} ,
Kaikai Wen ^{b, c} ,
Linlin Li ^{a, b, c, *,}

a.
School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China
b.
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
c.
School of Nanoscience and Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
d.
College of Chemistry and Material Science, Shandong Agricultural University, Tai'an 271018, China

lilinlin@binn.cas.cn

Received Date: 12 December 2023
Revised Date: 6 February 2024
Accepted Date: 7 February 2024
Available Online: 10 February 2024

Figures(6)

Sonodynamic therapy (SDT) exhibits noninvasive and accuracy in cancer treatment, and has aroused widespread attention. However, the low quantum yield of inorganic sonosensitizers under ultrasound (US) stimulation leads to unsatisfactory efficacy. In this work, an urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction was constructed as an efficient sonosensitizer for enhanced SDT. The p-n heterojunction formation narrows the band bandgap and increases the piezoelectric property, which contribute to the promotion of carrier separation and suppression of carrier recombination, resulting in enhanced SDT. Moreover, under tumor microenvironment (TME) with over produced H₂O₂ and glutathione (GSH), Cu₃P NNs induce chemodynamic therapy (CDT) by initiating a Fenton-like reaction and depleting GSH, leading to increased cellular oxidative damage. With the combination effect, the ZnSnO₃/Cu₃P heterojunction demonstrates a 70% tumor growth inhibition rate in 4T1 tumor mice model. This piezoelectric heterojunction achieves the combined treatment of SDT and CDT, and opens new possibilities for the application of SDT in tumor therapy.
- ZnSnO₃,
- Piezoelectric effect,
- Heterojunction,
- Chemodynamic therapy,
- Sonodynamic therapy,
- Reactive oxygen species
1. [1]
  S. Bai, N.L. Yang, X.W. Wang, et al., ACS Nano 14 (2020) 15119–15130. doi: 10.1021/acsnano.0c05235
2. [2]
  Y.M. Ding, Z. Wang, Z.Y. Zhang, et al., Nano Res. 15 (2022) 7304–7312. doi: 10.1007/s12274-022-4336-0
3. [3]
  Y. Zhao, T. Huang, X. Zhang, et al., BMEMat 1 (2023) e12006. doi: 10.1002/bmm2.12006
4. [4]
  D.D. Liu, X.L. Dai, W. Zhang, et al., Biomaterials 292 (2023) 121917. doi: 10.1016/j.biomaterials.2022.121917
5. [5]
  Y. Zhu, Y.J. Wang, G.R. Williams, et al., Adv. Sci. 7 (2020) 2000272. doi: 10.1002/advs.202000272
6. [6]
  X. Xue, H. Qu, Y. Li, Exploration 2 (2022) 20210134. doi: 10.1002/EXP.20210134
7. [7]
  Y. Zhang, X.Q. Zhang, H.C. Yang, et al., Chem. Soc. Rev. 50 (2021) 11227–11248. doi: 10.1039/d1cs00403d
8. [8]
  L.A. Sun, X.W. Wang, F. Gong, et al., Theranostics 11 (2021) 9234. doi: 10.7150/thno.58755
9. [9]
  Y.Q. Yang, X.W. Wang, H.S. Qian, L. Cheng, Appl. Mater. Today 25 (2021) 101215. doi: 10.1016/j.apmt.2021.101215
10. [10]
  M.F. Wang, P.A. Ma, J. Lin, Chin. Chem. Lett. 34 (2023) 108300. doi: 10.1016/j.cclet.2023.108300
11. [11]
  T.T. Hu, W.C. Shen, F.Q. Meng, et al., Adv. Mater. 35 (2023) 2209692. doi: 10.1002/adma.202209692
12. [12]
  A.B. Wu, L.D. Jiang, C. Xia, et al., Adv. Sci. 10 (2023) 2303016. doi: 10.1002/advs.202303016
13. [13]
  A.Q. Ma, H.Q. Chen, Y.H. Cui, et al., Small 15 (2019) 1804028. doi: 10.1002/smll.201804028
14. [14]
  S. Liang, X.R. Deng, P.A. Ma, Z.Y. Cheng, J. Lin, Adv. Mater. 32 (2020) 2003214. doi: 10.1002/adma.202003214
15. [15]
  X.Q. Qian, Y.Y. Zheng, Y. Chen, Adv. Mater. 28 (2016) 8097–8129. doi: 10.1002/adma.201602012
16. [16]
  Z.R. Gong, Z.F. Dai, Adv. Sci. 8 (2021) 2002178. doi: 10.1002/advs.202002178
17. [17]
  X.H. Lin, J.B. Song, X.Y. Chen, H.H. Yang, Angew. Chem. Int. Ed. 59 (2020) 14212–14233. doi: 10.1002/anie.201906823
18. [18]
  Y.F. Zhou, S.Y. Fan, L.L. Feng, X.L. Huang, X.Y. Chen, Adv. Mater. 33 (2021) 2104223. doi: 10.1002/adma.202104223
19. [19]
  P.R. Zhao, H.Y. Li, W.B. Bu, Angew. Chem. Int. Ed. 62 (2023) e2022104.
20. [20]
  S.P. Ning, X.L. Dai, W.W. Tang, et al., Acta Biomater. 152 (2022) 562–574. doi: 10.1016/j.actbio.2022.08.067
21. [21]
  Q.T. Hoang, V. Ravichandran, T.G.N. Cao, et al., Chem. Eng. J. 435 (2022) 135039. doi: 10.1016/j.cej.2022.135039
22. [22]
  P. Zhu, Y. Chen, J.L. Shi, Adv. Mater. 32 (2020) 2001976. doi: 10.1002/adma.202001976
23. [23]
  Y.C. Zhao, S.B. Wang, Y.M. Ding, et al., ACS Nano 16 (2022) 9304–9316. doi: 10.1021/acsnano.2c01968
24. [24]
  X.X. Deng, P. Chen, R.R. Cui, et al., Appl. Catal. B 339 (2023) 123148. doi: 10.1016/j.apcatb.2023.123148
25. [25]
  H.Q. Ma, W.Y. Yang, S. Gao, et al., Chem. Eng. J. 455 (2023) 140471. doi: 10.1016/j.cej.2022.140471
26. [26]
  J. Jang, K. Kim, J. Yoon, C.B. Park, Biomaterials 255 (2020) 120165. doi: 10.1016/j.biomaterials.2020.120165
27. [27]
  Z.L. Wang, Nano Today 5 (2010) 540–552. doi: 10.1016/j.nantod.2010.10.008
28. [28]
  Z.L. Wang, Adv. Mater. 24 (2012) 4632–4646. doi: 10.1002/adma.201104365
29. [29]
  Z.L. Wang, W.Z. Wu, Natl. Sci. Rev. 1 (2014) 62–90. doi: 10.1093/nsr/nwt002
30. [30]
  S. Chen, P. Zhu, L.J. Mao, et al., Adv. Mater. 35 (2023) 2208256. doi: 10.1002/adma.202208256
31. [31]
  Z.J. Wang, J. Liu, F.J. Wang, et al., J. Phys. Chem. C 114 (2010) 13577–13582. doi: 10.1021/jp104733e
32. [32]
  J. Zhang, K.L. Yao, Z.L. Liu, et al., Phys. Chem. Chem. Phys. 12 (2010) 9197–9204. doi: 10.1039/b920065g
33. [33]
  Y. Inaguma, M. Yoshida, T. Katsumata, J. Am. Chem. Soc. 130 (2008) 6704. doi: 10.1021/ja801843v
34. [34]
  K.Y. Lee, D. Kim, J.H. Lee, et al., Adv. Funct. Mater. 24 (2014) 37–43. doi: 10.1002/adfm.201301379
35. [35]
  S. Shawon, Z.D. Carballo, V.S. Vega, et al., Nano Energy 92 (2022) 106653. doi: 10.1016/j.nanoen.2021.106653
36. [36]
  X.S. Cao, M.X. Li, Q.Y. Liu, et al., Small 19 (2023) 2303195. doi: 10.1002/smll.202303195
37. [37]
  G.R. Dillip, P.C. Nagajyothi, R. Ramaraghavulu, et al., Mater. Chem. Phys. 248 (2020) 122946. doi: 10.1016/j.matchemphys.2020.122946
38. [38]
  B.J. Ma, S. Wang, F. Liu, et al., J. Am. Chem. Soc. 141 (2019) 849–857. doi: 10.1021/jacs.8b08714
39. [39]
  S.J. Zhong, C. Xiong, Y.C. Zhao, et al., Adv. Funct. Mater. 33 (2023) 2305625. doi: 10.1002/adfm.202305625
40. [40]
  Y.T. Zhao, L. Tao, Chin. Chem. Lett. 35 (2024) 108571. doi: 10.1016/j.cclet.2023.108571
41. [41]
  S. Wang, S.Q. Yang, Z.L. Cui, et al., Chem. Eng. J. 457 (2023) 141186. doi: 10.1016/j.cej.2022.141186
42. [42]
  H. Lei, Z. Pei, C. Jiang, L. Cheng, Exploration 3 (2023) 20220001. doi: 10.1002/EXP.20220001
43. [43]
  D. Jana, Y. Zhao, Exploration 2 (2022) 20210238. doi: 10.1002/EXP.20210238
44. [44]
  J.A. Malla, R.M. Umesh, S. Yousf, et al., Angew. Chem., Int. Ed. 59 (2020) 7944–7952. doi: 10.1002/anie.202000961
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6. [6]
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Urchin-like piezoelectric ZnSnO3/Cu3P p-n heterojunction for enhanced cancer sonodynamic therapy

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通讯作者: 陈斌, bchen63@163.com

Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy