Citation: Bowen Wang, Longwu Sun, Qianqian Cao, Xinzhi Li, Jianai Chen, Shizhao Wang, Miaolin Ke, Fener Chen. Cu-catalyzed three-component CSP coupling for the synthesis of trisubstituted allenyl phosphorothioates[J]. Chinese Chemical Letters, ;2024, 35(12): 109617. doi: 10.1016/j.cclet.2024.109617 shu

Cu-catalyzed three-component CSP coupling for the synthesis of trisubstituted allenyl phosphorothioates

Bowen Wang ^{a, 1} ,
Longwu Sun ^{a, 1} ,
Qianqian Cao ^a ,
Xinzhi Li ^a ,
Jianai Chen ^a ,
Shizhao Wang ^{a, *,} ,
Miaolin Ke ^{a, *,} ,
Fener Chen ^{a, b, c, *,}

a.
Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
b.
Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China
c.
Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China

^**

wangsz@zjut.edu.cn

kemiaolin@126.com

rfchen@fudan.edu.cn

Received Date: 23 October 2023
Revised Date: 23 January 2024
Accepted Date: 6 February 2024
Available Online: 20 February 2024

Figures(6)

A copper-catalyzed three-component reaction involving cyclic carbonates, elemental sulfur, and H-phosphonates is presented. It proceeds with excellent yields and provides an attractive approach for the construction of valuable trisubstituted allenyl phosphorothioates using a one-step strategy. Moreover, this method can be easily adapted to large-scale preparation.
- Cu-catalyzed,
- Construction of CSP bond,
- Three-component reaction,
- Elemental sulfur,
- Allenyl phosphorothioates
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