Citation: Zhe-Han Yang, Jie Yin, Lei Xin, Yuanfang Li, Yijie Huang, Ruo Yuan, Ying Zhuo. Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment[J]. Chinese Chemical Letters, ;2024, 35(10): 109558. doi: 10.1016/j.cclet.2024.109558 shu

Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment

Zhe-Han Yang ^{a, 1,} ,
Jie Yin ^{a, 1} ,
Lei Xin ^a ,
Yuanfang Li ^a ,
Yijie Huang ^a ,
Ruo Yuan ^b ,
Ying Zhuo ^{b, *,}

a.
Chongqing Key Laboratory of Catalysis and Functional Organic Molecules, College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China
b.
Key Laboratory of Luminescence and Real-Time Analytic Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

yzhzn89@ctbu.edu.cn

Yingzhuo@swu.edu.cn

Received Date: 29 September 2023
Revised Date: 29 December 2023
Accepted Date: 24 January 2024
Available Online: 26 January 2024

Figures(8)

DNA-based hydrogels are exceptional materials for biological applications because of their numerous advantages such as biodegradability, biocompatibility, hydrophilicity, super absorbency, porosity, and swelling. Among these advantages, the ability of DNA-based hydrogels to respond to specific physical and chemical triggers and undergo reversible phase transitions has garnered significant attention in the fields of disease diagnosis (biosensors) and treatment (drug delivery). This article focuses on the recent advancements in the research of DNA-based hydrogels and discusses the different types of these hydrogels, the synthetic methods, their unique properties, and their applications in biosensors and drug delivery. The types of DNA hydrogels are categorized based on their building blocks, and the process of synthesis as well as the unique characteristics of DNA-based hydrogels are described. Then, DNA-based responsive hydrogels utilized as intelligent materials for the development of biosensors are reviewed. Furthermore, this article also presents the current status of DNA-based responsive hydrogels in drug delivery for cancer treatment, wound healing, and other therapeutic applications. Ultimately, this paper discusses the current challenges in expanding the practical application of DNA-based hydrogels.
- DNA-based hydrogel,
- Intelligent hydrogel,
- Manufacture,
- Characteristics,
- Disease diagnosis and treatment
1. [1]
  N.A. Peppas, J.Z. Hilt, A. Khademhosseini, et al., Adv. Mater. 18 (2006) 1345–1360. doi: 10.1002/adma.200501612
2. [2]
  W. Yu, E. Gong, B. Liu, et al., Chin. Chem. Lett. 34 (2023) 108205. doi: 10.1016/j.cclet.2023.108205
3. [3]
  Z. Zhao, X. Fan, S. Wang, et al., Chin. Chem. Lett. 34 (2023) 107892. doi: 10.1016/j.cclet.2022.107892
4. [4]
  G. Liu, Y. Zhou, Z. Xu, et al., Chin. Chem. Lett. 34 (2023) 107705. doi: 10.1016/j.cclet.2022.07.048
5. [5]
  F.G. Downs, D.J. Lunn, M.J. Booth, et al., Nat. Chem. 12 (2020) 363–371. doi: 10.1038/s41557-020-0444-1
6. [6]
  D. Jung, K.M. Lee, J.Y. Chang, et al., ACS Appl. Mater. Interfaces 10 (2018) 42985–42991. doi: 10.1021/acsami.8b14528
7. [7]
  S.J. Jeon, A.W. Hauser, R.C. Hayward, Acc. Chem. Res. 50 (2017) 161–169. doi: 10.1021/acs.accounts.6b00570
8. [8]
  X. Le, W. Lu, J. Zhang, et al., Adv. Sci. 6 (2019) 1801584. doi: 10.1002/advs.201801584
9. [9]
  D. Zhang, B. Ren, Y. Zhang, et al., J. Mater. Chem. B 8 (2020) 3171–3191. doi: 10.1039/c9tb02692d
10. [10]
  Y. Liu, M. Zhu, M. Meng, et al., Chin. Chem. Lett. 34 (2023) 107583. doi: 10.1016/j.cclet.2022.06.006
11. [11]
  S. Chen, L. Yin, L. Liu, et al., Chin. Chem. Lett. 32 (2021) 3133–3136. doi: 10.1016/j.cclet.2021.03.059
12. [12]
  X. Mao, D. Mao, T. Chen, et al., ACS Appl. Mater. Interfaces 12 (2020) 36851–36859. doi: 10.1021/acsami.0c08064
13. [13]
  Y. Liu, J. Cheng, S. Fan, et al., Angew. Chem. Int. Ed. 59 (2020) 23277–23282. doi: 10.1002/anie.202010433
14. [14]
  L. He, J. Mu, O. Gang, et al., Adv. Sci. 8 (2021) 2003775. doi: 10.1002/advs.202003775
15. [15]
  Y. Dong, C. Yao, Y. Zhu, et al., Chem. Rev. 120 (2020) 9420–9481. doi: 10.1021/acs.chemrev.0c00294
16. [16]
  C. Wang, M.P. O'Hagan, Z. Li, et al., Chem. Soc. Rev. 51 (2022) 720–760. doi: 10.1039/d1cs00688f
17. [17]
  Y. Tian, J.R. Lhermitte, L. Bai, et al., Nat. Mater. 19 (2020) 789–796. doi: 10.1038/s41563-019-0550-x
18. [18]
  J.S. Kahn, Y. Hu, I. Willner, Acc. Chem. Res. 50 (2017) 680–690. doi: 10.1021/acs.accounts.6b00542
19. [19]
  Y. Shao, H. Jia, T. Cao, et al., Acc. Chem. Res. 50 (2017) 659–668. doi: 10.1021/acs.accounts.6b00524
20. [20]
  D. Wang, Y. Hu, P. Liu, et al., Acc. Chem. Res. 50 (2017) 733–739. doi: 10.1021/acs.accounts.6b00581
21. [21]
  S. Iqbal, F. Ahmed, H. Xiong, Chem. Eng. J. 420 (2021) 130384. doi: 10.1016/j.cej.2021.130384
22. [22]
  L. Zhao, L. Li, G. Yang, et al., Biosens. Bioelectron. 194 (2021) 113597. doi: 10.1016/j.bios.2021.113597
23. [23]
  P. Chen, C. Yu, J. Chen, et al., Chin. Chem. Lett. 34 (2023) 108627. doi: 10.1016/j.cclet.2023.108627
24. [24]
  Y. Huang, W. Xu, G. Liu, et al., Chem. Commun. 53 (2017) 3038–3041. doi: 10.1039/C7CC00636E
25. [25]
  S. Lu, S. Wang, J. Zhao, et al., Chem. Commun. 54 (2018) 4621–4624. doi: 10.1039/c8cc01603h
26. [26]
  Y. Wei, K. Wang, S. Luo, et al., Small 18 (2022) e2107640. doi: 10.1002/smll.202107640
27. [27]
  F. Li, D. Lyu, S. Liu, et al., Adv. Mater. 32 (2020) e1806538. doi: 10.1002/adma.201806538
28. [28]
  V. Morya, S. Walia, B.B. Mandal, et al., ACS Biomater. Sci. Eng. 6 (2020) 6021–6035. doi: 10.1021/acsbiomaterials.0c01125
29. [29]
  N. Ren, R. Sun, K. Xia, et al., ACS Appl. Mater. Interfaces 11 (2019) 26704–26710. doi: 10.1021/acsami.9b08652
30. [30]
  J.B. Lee, S. Peng, D. Yang, et al., Nat. Nanotechnol. 7 (2012) 816–820. doi: 10.1038/nnano.2012.211
31. [31]
  Y. Xing, E. Cheng, Y. Yang, et al., Adv. Mater. 23 (2011) 1117–1121. doi: 10.1002/adma.201003343
32. [32]
  M.M. Bhanjadeo, A.K. Nayak, U. Subudhi, Biochem. Biophys. Res. Commun. 485 (2017) 492–498. doi: 10.1016/j.bbrc.2017.02.024
33. [33]
  S.H. Um, J.B. Lee, N. Park, et al., Nat. Mater. 5 (2006) 797–801. doi: 10.1038/nmat1741
34. [34]
  S. Basu, S. Pacelli, Y. Feng, et al., ACS Nano 12 (2018) 9866–9880. doi: 10.1021/acsnano.8b02434
35. [35]
  W. -C. Liao, S. Lilienthal, J.S. Kahn, et al., Chem. Sci. 8 (2017) 3362–3373. doi: 10.1039/C6SC04770J
36. [36]
  S. Nagahara, T. Matsuda, Polym. Gels Netw. 4 (1996) 111–127. doi: 10.1016/0966-7822(96)00001-9
37. [37]
  S. Lilienthal, Z. Shpilt, F. Wang, et al., ACS Appl. Mater. Interfaces 7 (2015) 8923–8931. doi: 10.1021/acsami.5b02156
38. [38]
  Y. Mao, J. Li, J. Yan, et al., Chem. Commun. 53 (2017) 6375–6378. doi: 10.1039/C7CC01360D
39. [39]
  S. Liu, W. Su, Y. Li, et al., Biosens. Bioelectron. 103 (2018) 1–5. doi: 10.1016/j.bios.2017.12.021
40. [40]
  J. Song, K. Im, S. Hwang, et al., Nanoscale 7 (2015) 9433–9437. doi: 10.1039/C5NR00858A
41. [41]
  L. Zhang, S.R. Jean, S. Ahmed, et al., Nat. Commun. 8 (2017) 1–9. doi: 10.1038/s41467-016-0009-6
42. [42]
  H. Kang, A.C. Trondoli, G. Zhu, et al., ACS Nano 5 (2011) 5094–5099. doi: 10.1021/nn201171r
43. [43]
  W. Bai, D.A. Spivak, Angew. Chem. Int. Ed. 53 (2014) 2095–2098. doi: 10.1002/anie.201309462
44. [44]
  X. Meng, K. Zhang, W. Dai, et al., Chem. Sci. 9 (2018) 7419–7425. doi: 10.1039/c8sc02858c
45. [45]
  L. Hao, W. Wang, X. Shen, et al., J. Agric. Food. Chem. 68 (2019) 369–375.
46. [46]
  T. Noll, S. Wenderhold-Reeb, H. Schonherr, et al., Angew. Chem. Int. Ed. 56 (2017) 12004–12008. doi: 10.1002/anie.201705001
47. [47]
  E. Cheng, Y. Xing, P. Chen, et al., Angew. Chem. Int. Ed. 48 (2009) 7660–7663. doi: 10.1002/anie.200902538
48. [48]
  T. Nöll, H. Schönherr, D. Wesner, et al., Angew. Chem. 126 (2014) 8468–8472. doi: 10.1002/ange.201402497
49. [49]
  R. Merindol, G. Delechiave, L. Heinen, et al., Nat. Commun. 10 (2019) 528. doi: 10.1038/s41467-019-08428-2
50. [50]
  C. Yao, H. Tang, W. Wu, et al., J. Am. Chem. Soc. 142 (2020) 3422–3429. doi: 10.1021/jacs.9b11001
51. [51]
  Y.A. Pardo, K.G. Yancey, D.S. Rosenwasser, et al., Mater. Today 53 (2022) 98–105. doi: 10.1016/j.mattod.2021.10.029
52. [52]
  A. Cangialosi, C. Yoon, J. Liu, et al., Science 357 (2017) 1126–1130. doi: 10.1126/science.aan3925
53. [53]
  F.X. Jiang, B. Yurke, B.L. Firestein, et al., Ann. Biomed. Eng. 36 (2008) 1565–1579. doi: 10.1007/s10439-008-9530-z
54. [54]
  M.L. Previtera, U. Chippada, R.S. Schloss, et al., Biores. Open Access 1 (2012) 256–259. doi: 10.1089/biores.2012.9906
55. [55]
  G.C. Aran, C. Bayraç, Bioconj. Chem. 34 (2023) 922–933. doi: 10.1021/acs.bioconjchem.3c00130
56. [56]
  Y. Hu, S. Gao, H. Lu, et al., J. Am. Chem. Soc. 144 (2022) 5461–5470. doi: 10.1021/jacs.1c13426
57. [57]
  Y. Hu, Y. Ke, I. Willner, Adv. Funct. Mater. 33 (2023) 2304966.
58. [58]
  C.H. Lu, X.J. Qi, R. Orbach, et al., Nano Lett. 13 (2013) 1298–1302. doi: 10.1021/nl400078g
59. [59]
  C.H. Lu, W. Guo, Y. Hu, et al., J. Am. Chem. Soc. 137 (2015) 15723–15731. doi: 10.1021/jacs.5b06510
60. [60]
  L. Yan, Z. Zhu, Y. Zou, et al., J. Am. Chem. Soc. 135 (2013) 3748–3751. doi: 10.1021/ja3114714
61. [61]
  Q. Wang, Y. Hu, N. Jiang, et al., Bioconjug. Chem. 31 (2020) 813–820. doi: 10.1021/acs.bioconjchem.9b00874
62. [62]
  Y. Bian, Z. Zhou, G. Li, et al., Sens. Actuat. B 380 (2023) 133402. doi: 10.1016/j.snb.2023.133402
63. [63]
  L. Tang, Y. Huang, C. Lin, et al., Talanta 214 (2020) 120862. doi: 10.1016/j.talanta.2020.120862
64. [64]
  C.H. Lu, W. Guo, Y. Hu, et al., J. Am. Chem. Soc. 137 (2015) 15723–15731. doi: 10.1021/jacs.5b06510
65. [65]
  F. Huang, M. Chen, Z. Zhou, et al., Nat. Commun. 12 (2021) 2364. doi: 10.1038/s41467-021-22645-8
66. [66]
  J. Tang, X. Jia, Q. Li, et al., Proc. Natl. Acad. Sci. U. S. A. 120 (2023) e2303822120. doi: 10.1073/pnas.2303822120
67. [67]
  A. Pourdadashi, R. Rezaei Adriani, S.L. Mousavi Gargari, J. Biosci. Bioeng. 134 (2022) 441–449. doi: 10.1016/j.jbiosc.2022.07.009
68. [68]
  C. Wang, J. Zhang, ACS Appl. Bio. Mater. 5 (2022) 1934–1953. doi: 10.1021/acsabm.1c01197
69. [69]
  H. Peng, A.M. Newbigging, Z. Wang, et al., Anal. Chem. 90 (2018) 190–207. doi: 10.1021/acs.analchem.7b04926
70. [70]
  M. Chen, Y. Wang, J. Zhang, et al., J. Nanobiotechnol. 20 (2022) 40. doi: 10.1186/s12951-022-01242-x
71. [71]
  J. Zhao, C. He, Y. Long, et al., Anal. Chim. Acta 1276 (2023) 341642. doi: 10.1016/j.aca.2023.341642
72. [72]
  F. Mo, K. Jiang, D. Zhao, et al., Adv. Drug Deliv. Rev. 168 (2021) 79–98. doi: 10.1016/j.addr.2020.07.018
73. [73]
  K. Yazdani, S. Seshadri, D. Tillo, et al., Nucleic Acids Res. 51 (2023) 12020–12030. doi: 10.1093/nar/gkad981
74. [74]
  S. Singh, A. Mishra, R. Kumari, et al., Carbon 114 (2017) 169–176. doi: 10.1016/j.carbon.2016.12.020
75. [75]
  Y. Zhang, L. Zhu, J. Tian, et al., Adv. Sci. 8 (2021) 2100216. doi: 10.1002/advs.202100216
76. [76]
  C. Wang, M. Fadeev, J. Zhang, et al., Chem. Sci. 9 (2018) 7145–7152. doi: 10.1039/c8sc02411a
77. [77]
  D. Cao, Y. Xie, J. Song, Macromol. Rapid Commun. 43 (2022) e2200281. doi: 10.1002/marc.202200281
78. [78]
  X. Liu, J. Zhang, M. Fadeev, et al., Chem. Sci. 10 (2019) 1008–1016. doi: 10.1039/c8sc04292f
79. [79]
  S. Basu, R. Johl, S. Pacelli, et al., ACS Macro. Lett. 9 (2020) 1230–1236. doi: 10.1021/acsmacrolett.0c00448
80. [80]
  X. Du, P.P. He, C. Wang, et al., Adv. Mater. 35 (2023) e2206302. doi: 10.1002/adma.202206302
81. [81]
  F. Mo, K. Jiang, D. Zhao, et al., Adv. Drug Del. Rev. 168 (2021) 79–98. doi: 10.1016/j.addr.2020.07.018
82. [82]
  C. Du, R.J. Hill, Macromolecules 52 (2019) 6683–6697. doi: 10.1021/acs.macromol.9b01338
83. [83]
  C.O. Akintayo, G. Creusen, P. Straub, et al., Macromolecules 54 (2021) 7125–7133. doi: 10.1021/acs.macromol.1c00600
84. [84]
  Q. Chen, L. Wu, F. Zhao, et al., Food Chem. 418 (2023) 135891. doi: 10.1016/j.foodchem.2023.135891
85. [85]
  Q. Hu, K. Dong, J. Ming, et al., Mater. Today Chem. 23 (2022) 100680. doi: 10.1016/j.mtchem.2021.100680
86. [86]
  J. Tang, X. Jia, Q. Li, et al., Proc. Natl. Acad. Sci 120 (2023) e2303822120. doi: 10.1073/pnas.2303822120
87. [87]
  X. Du, Y. Bi, P. He, et al., Adv. Funct. Mater. 30 (2020) 2006305. doi: 10.1002/adfm.202006305
88. [88]
  A.T. Uzumcu, O. Guney, O. Okay, Polymer 100 (2016) 169–178. doi: 10.1016/j.polymer.2016.08.041
89. [89]
  M.Z. Quazi, N. Park, Biomacromolecules 24 (2023) 2127–2137. doi: 10.1021/acs.biomac.3c00021
90. [90]
  C. Wang, B. Willner, I. Willner, React. Funct. Polym. 166 (2021) 104983.
91. [91]
  P.P. He, X. Du, Y. Cheng, et al., Small 18 (2022) 2200263. doi: 10.1002/smll.202200263
92. [92]
  X. Fu, T. Chen, Y. Song, et al., Small 17 (2021) 2101224. doi: 10.1002/smll.202101224
93. [93]
  X. Ma, Z. Yang, Y. Wang, et al., ACS Appl. Mater. Interfaces 9 (2017) 1995–2000. doi: 10.1021/acsami.6b12327
94. [94]
  G.C. Aran, C. Bayrac, Bioconjug. Chem. 34 (2023) 922–933. doi: 10.1021/acs.bioconjchem.3c00130
95. [95]
  S. Li, Z. Wang, X. Lin, et al., Analyst 148 (2023) 4730–4737. doi: 10.1039/d3an01011b
96. [96]
  Q. Yang, Y. Wang, T. Liu, et al., ACS Nano 16 (2022) 18366–18375. doi: 10.1021/acsnano.2c06261
97. [97]
  S. Liu, Y. Yang, M. Shi, et al., ACS Sens. 7 (2022) 658–665. doi: 10.1021/acssensors.1c02662
98. [98]
  W.H. Chang, Y.F. Lee, Y.W. Liu, et al., Nanoscale 13 (2021) 16799–16808. doi: 10.1039/d1nr05170a
99. [99]
  M. Mao, S. Fu, Y. Lu, et al., J. Lumin. 238 (2021) 118250. doi: 10.1016/j.jlumin.2021.118250
100. [100]
  W. Chen, J. Li, X. Wei, et al., Microchim. Acta 187 (2020) 1–10. doi: 10.1007/s00604-019-3921-8
101. [101]
  Y. Si, L. Xu, N. Wang, et al., Anal. Chem. 92 (2020) 2649–2655. doi: 10.1021/acs.analchem.9b04606
102. [102]
  M. Liu, W. Ma, Y. Zhou, et al., ACS Sens. 7 (2022) 3153–3160. doi: 10.1021/acssensors.2c01636
103. [103]
  X. Zhang, Z. Zhang, C. Yang, et al., Analyst 147 (2022) 2757–2763. doi: 10.1039/d2an00667g
104. [104]
  M.L. Zhao, W.J. Zeng, Y.Q. Chai, et al., Anal. Chem. 92 (2020) 11044–11052. doi: 10.1021/acs.analchem.0c00152
105. [105]
  F. Jin, Q. Zeng, H. Qian, et al., Front. Pharmacol. 13 (2022) 807498. doi: 10.3389/fphar.2022.807498
106. [106]
  P.P. He, X. Du, Y. Cheng, et al., Small 18 (2022) e2200263. doi: 10.1002/smll.202200263
107. [107]
  X. Liu, M. Ma, S. Tian, et al., Eur. J. Med. Chem. 256 (2023) 115441. doi: 10.1016/j.ejmech.2023.115441
108. [108]
  L. Zhou, W. Pi, M. Hao, et al., Biomater. Sci. 9 (2021) 4904–4921. doi: 10.1039/d1bm00568e
109. [109]
  L. Zhou, W. Pi, S. Cheng, et al., Adv. Funct. Mater. 31 (2021) 2106167. doi: 10.1002/adfm.202106167
110. [110]
  Z. Wang, W. Li, L. Gou, et al., Adv. Healthc. Mater. 11 (2022) 2200782. doi: 10.1002/adhm.202200782
111. [111]
  F. Gao, X. Ma, F. Wang, et al., Chem. Eng. J. 470 (2023) 144347. doi: 10.1016/j.cej.2023.144347
112. [112]
  X. Fu, T. Chen, Y. Song, et al., Small 17 (2021) e2101224. doi: 10.1002/smll.202101224
1. [1]
  Zheyi Li , Xiaoyang Liang , Zitong Qiu , Zimeng Liu , Siyu Wang , Yue Zhou , Nan Li . Ion-interferential cell cycle arrest for melanoma treatment based on magnetocaloric bimetallic-ion sustained release hydrogel. Chinese Chemical Letters, 2024, 35(11): 109592-. doi: 10.1016/j.cclet.2024.109592
2. [2]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
3. [3]
  Zhenyang Lin . A classification scheme for inorganic cluster compounds based on their electronic structures and bonding characteristics. Chinese Journal of Structural Chemistry, 2024, 43(5): 100254-100254. doi: 10.1016/j.cjsc.2024.100254
4. [4]
  Hongyun Liu , Jiarun Li , Xinyi Li , Zhe Liu , Jiaxuan Li , Cong Xiao . Course Ideological and Political Design of a Comprehensive Chemistry Experiment: Constructing a Visual Molecular Logic System Based on Intelligent Hydrogel Film Electrodes. University Chemistry, 2024, 39(2): 227-233. doi: 10.3866/PKU.DXHX202309070
5. [5]
  Zhongyu Wang , Lijun Wang , Huaixin Zhao . DNA-based nanosystems to generate reactive oxygen species for nanomedicine. Chinese Chemical Letters, 2024, 35(11): 109637-. doi: 10.1016/j.cclet.2024.109637
6. [6]
  Jianye Kang , Xinyu Yang , Xuhao Yang , Jiahui Sun , Yuhang Liu , Shutao Wang , Wenlong Song . Carbon dots-enhanced pH-responsive lubricating hydrogel based on reversible dynamic covalent bondings. Chinese Chemical Letters, 2024, 35(5): 109297-. doi: 10.1016/j.cclet.2023.109297
7. [7]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
8. [8]
  Caihong Mao , Yanfeng He , Xiaohan Wang , Yan Cai , Xiaobo Hu . Synthesis and molecular recognition characteristics of a tetrapodal benzene cage. Chinese Chemical Letters, 2024, 35(8): 109362-. doi: 10.1016/j.cclet.2023.109362
9. [9]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
10. [10]
  Guilong Li , Wenbo Ma , Jialing Zhou , Caiqin Wu , Chenling Yao , Huan Zeng , Jian Wang . A composite hydrogel with porous and homogeneous structure for efficient osmotic energy conversion. Chinese Chemical Letters, 2025, 36(2): 110449-. doi: 10.1016/j.cclet.2024.110449
11. [11]
  Kai An , Qinglong Qiao , Lovelesh , Syed Ali Abbas Abedi , Xiaogang Liu , Zhaochao Xu . "Superimposed" spectral characteristics of fluorophores arising from cross-conjugation hybridization. Chinese Chemical Letters, 2025, 36(1): 109786-. doi: 10.1016/j.cclet.2024.109786
12. [12]
  Xin Li , Xuan Ding , Junkun Zhou , Hui Shi , Zhenxi Dai , Jiayi Liu , Yongcun Ma , Penghui Shao , Liming Yang , Xubiao Luo . Utilizing synergistic effects of bifunctional polymer hydrogel PAM-PAMPS for selective capture of Pb(Ⅱ) from wastewater. Chinese Chemical Letters, 2024, 35(7): 109158-. doi: 10.1016/j.cclet.2023.109158
13. [13]
  Xinyue Lan , Junguang Liang , Churan Wen , Xiaolong Quan , Huimin Lin , Qinqin Xu , Peixian Chen , Guangyu Yao , Dan Zhou , Meng Yu . Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy. Chinese Chemical Letters, 2024, 35(4): 108616-. doi: 10.1016/j.cclet.2023.108616
14. [14]
  Zhibin Ren , Shan Li , Xiaoying Liu , Guanghao Lv , Lei Chen , Jingli Wang , Xingyi Li , Jiaqing Wang . Penetrating efficiency of supramolecular hydrogel eye drops: Electrostatic interaction surpasses ligand-receptor interaction. Chinese Chemical Letters, 2024, 35(11): 109629-. doi: 10.1016/j.cclet.2024.109629
15. [15]
  Haijun Shen , Yi Qiao , Chun Zhang , Yane Ma , Jialing Chen , Yingying Cao , Wenna Zheng . A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing. Chinese Chemical Letters, 2024, 35(12): 110283-. doi: 10.1016/j.cclet.2024.110283
16. [16]
  Tong Zhang , Xiaojing Liang , Licheng Wang , Shuai Wang , Xiaoxiao Liu , Yong Guo . An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography. Chinese Chemical Letters, 2025, 36(1): 109889-. doi: 10.1016/j.cclet.2024.109889
17. [17]
  Jiajia Wang , XinXin Ge , Yajing Xiang , Xiaoliang Qi , Ying Li , Hangbin Xu , Erya Cai , Chaofan Zhang , Yulong Lan , Xiaojing Chen , Yizuo Shi , Zhangping Li , Jianliang Shen . An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing. Chinese Chemical Letters, 2025, 36(2): 109819-. doi: 10.1016/j.cclet.2024.109819
18. [18]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
19. [19]
  Yu Yan , Jiawei Song , Dongdong Liu , Zihan Liu , Jialing Cheng , Zhiyang Chen , Yanfang Yang , Weizhe Jiang , Hongliang Wang , Jun Ye , Yuling Liu . Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis. Chinese Chemical Letters, 2024, 35(6): 109736-. doi: 10.1016/j.cclet.2024.109736
20. [20]
  Hui Liu , Xi Xiang , Jian-Bo Huang , Bi-Hui Zhu , Li-Yun Wang , Yuan-Jiao Tang , Fang-Xue Du , Ling Li , Feng Yan , Lang Ma , Li Qiu . Corrigendum to "Ultrasound augmenting injectable chemotaxis hydrogel for articular cartilage repair in osteoarthritis" [Chinese Chemical Letters 32 (2021) 1759-1764]. Chinese Chemical Letters, 2025, 36(2): 110562-. doi: 10.1016/j.cclet.2024.110562

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沈阳化工大学材料科学与工程学院沈阳 110142