Citation: Zhe-Han Yang, Jie Yin, Lei Xin, Yuanfang Li, Yijie Huang, Ruo Yuan, Ying Zhuo. Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment[J]. Chinese Chemical Letters, ;2024, 35(10): 109558. doi: 10.1016/j.cclet.2024.109558 shu

Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment

Zhe-Han Yang ^{a, 1,} ,
Jie Yin ^{a, 1} ,
Lei Xin ^a ,
Yuanfang Li ^a ,
Yijie Huang ^a ,
Ruo Yuan ^b ,
Ying Zhuo ^{b, *,}

a.
Chongqing Key Laboratory of Catalysis and Functional Organic Molecules, College of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China
b.
Key Laboratory of Luminescence and Real-Time Analytic Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

yzhzn89@ctbu.edu.cn

Yingzhuo@swu.edu.cn

Received Date: 29 September 2023
Revised Date: 29 December 2023
Accepted Date: 24 January 2024
Available Online: 26 January 2024

Figures(8)

DNA-based hydrogels are exceptional materials for biological applications because of their numerous advantages such as biodegradability, biocompatibility, hydrophilicity, super absorbency, porosity, and swelling. Among these advantages, the ability of DNA-based hydrogels to respond to specific physical and chemical triggers and undergo reversible phase transitions has garnered significant attention in the fields of disease diagnosis (biosensors) and treatment (drug delivery). This article focuses on the recent advancements in the research of DNA-based hydrogels and discusses the different types of these hydrogels, the synthetic methods, their unique properties, and their applications in biosensors and drug delivery. The types of DNA hydrogels are categorized based on their building blocks, and the process of synthesis as well as the unique characteristics of DNA-based hydrogels are described. Then, DNA-based responsive hydrogels utilized as intelligent materials for the development of biosensors are reviewed. Furthermore, this article also presents the current status of DNA-based responsive hydrogels in drug delivery for cancer treatment, wound healing, and other therapeutic applications. Ultimately, this paper discusses the current challenges in expanding the practical application of DNA-based hydrogels.
- DNA-based hydrogel,
- Intelligent hydrogel,
- Manufacture,
- Characteristics,
- Disease diagnosis and treatment
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沈阳化工大学材料科学与工程学院沈阳 110142