Citation: Ying Gao, Rong Zhou, Qiwen Wang, Shaolong Qi, Yuanyuan Lv, Shuang Liu, Jie Shen, Guocan Yu. Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy[J]. Chinese Chemical Letters, ;2024, 35(10): 109521. doi: 10.1016/j.cclet.2024.109521 shu

Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

Ying Gao ^{a, b} ,
Rong Zhou ^{a, b} ,
Qiwen Wang ^{c, *,} ,
Shaolong Qi ^d ,
Yuanyuan Lv ^{a, b} ,
Shuang Liu ^{e, *,} ,
Jie Shen ^{a, b, *,} ,
Guocan Yu ^{d, *,}

a.
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
b.
Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, China
c.
Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
d.
MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China
e.
Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China

wangqiwen@zju.edu.cn

liushuang80@pumch.cn

shenj@zucc.edu.cn

guocanyu@mail.tsinghua.edu.cn

Received Date: 23 November 2023
Revised Date: 8 January 2024
Accepted Date: 15 January 2024
Available Online: 20 January 2024

Figures(5)

Photodynamic therapy (PDT) has garnered significant attention as a promising approach to cancer therapy, harnessing the combined benefits of localized light treatment and the accompanying host immune response. In this study, we engineered an immuno-enhanced PDT nanoplatform, denoted as HM@p-MOF (hybrid membrane@porphyrin-metal organic framework). The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells, resulting in enhanced stability. In both in vitro and in vivo experiments, our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform, leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death (ICD) induced by photodynamic effects. Additionally, in conjunction with the immunomodulatory functions of the NK cell membrane, we observed an expansion of in situ immune infiltration leading to a systemic immune response. The HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress metastasis. This innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic tumors. It provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.
- Biomimetic,
- Cell membrane,
- Metal-organic framework,
- Phototherapy,
- Tumor targeting
1. [1]
  Y. Xia, L. Rao, H. Yao, et al., Adv. Mater. 32 (2020) 2002054. doi: 10.1002/adma.202002054
2. [2]
  S. Cheng, C. Xu, Y. Jin, et al., Adv. Sci. 7 (2020) 1903301. doi: 10.1002/advs.201903301
3. [3]
  E. Vivier, E. Tomasello, M. Baratin, et al., Nat. Immunol. 9 (2008) 503–510. doi: 10.1038/ni1582
4. [4]
  G. Deng, Z. Sun, S. Li, et al., ACS Nano 12 (2018) 12096–12108. doi: 10.1021/acsnano.8b05292
5. [5]
  M.J. Smyth, Y. Hayakawa, K. Takeda, et al., Nat. Rev. Cancer 2 (2002) 850–861. doi: 10.1038/nrc928
6. [6]
  D. Piccioli, S. Sbrana, E. Melandri, et al., J. Exp. Med. 195 (2002) 335–341. doi: 10.1084/jem.20010934
7. [7]
  L. Chiossone, P.Y. Dumas, M. Vienne, et al., Nat. Rev. Immunol. 18 (2018) 671–688. doi: 10.1038/s41577-018-0061-z
8. [8]
  A. Diefenbach, A.M. Jamieson, S.D. Liu, et al., Nat. Immunol. 1 (2000) 119–126. doi: 10.1038/77793
9. [9]
  G. Deng, X. Peng, Z. Sun, et al., ACS Nano 14 (2020) 11452–11462. doi: 10.1021/acsnano.0c03824
10. [10]
  D.E.J.G.J. Dolmans, D. Fukumura, R.K. Jain, Nat. Rev. Cancer 3 (2003) 380–387. doi: 10.1038/nrc1071
11. [11]
  L. Benov, Med. Princ. Pract. 24 (2015) 14–28. doi: 10.1159/000362416
12. [12]
  L.D. Yue, K.K. Yang, J.W. Wei, et al., CCS Chem. 4 (2022) 1745–1757. doi: 10.31635/ccschem.021.202101029
13. [13]
  M.L. Agarwal, H.E. Larkin, S.I. Zaidi, et al., Cancer Res. 53 (1993) 5897–5902.
14. [14]
  W.J. de Vree, A.N. Fontijne-Dorsman, J.F. Koster, et al., Br. J. Cancer 73 (1996) 1335–1340. doi: 10.1038/bjc.1996.255
15. [15]
  D.V. Krysko, A.D. Garg, A. Kaczmarek, et al., Nat. Rev. Cancer 12 (2012) 860–875. doi: 10.1038/nrc3380
16. [16]
  X.P. Duan, C. Chan, W.B. Lin, Angew. Chem. Int. Ed. 58 (2019) 670–680. doi: 10.1002/anie.201804882
17. [17]
  R.H. Fang, A.V. Kroll, W. Gao, et al., Adv. Mater. 30 (2018) 1706759. doi: 10.1002/adma.201706759
18. [18]
  B. Zhang, L. Lin, J. Mao, et al., Chin. Chem. Lett. 34 (2023) 108518. doi: 10.1016/j.cclet.2023.108518
19. [19]
  X.F. Bai, Y. Chen, M.Z. Zou, et al., ACS Nano 16 (2022) 18555–18567. doi: 10.1021/acsnano.2c06871
20. [20]
  H.T. Zhang, R. Peng, S. Chen, A. Shen, et al., Adv. Sci. 9 (2022) e2202039. doi: 10.1002/advs.202202039
21. [21]
  W. Hao, Y. Cui, Y. Fan, M. Chen, et al., J. Nanobiotechnology 19 (2021) 378. doi: 10.1186/s12951-021-01110-0
22. [22]
  C. Gao, Q. Cheng, J.Y. Li, et al., Adv. Funct. Mater. 31 (2021) 2102440. doi: 10.1002/adfm.202102440
23. [23]
  C. Gao, C.H.T. Kwong, Q.F. Wang, et al., ACS Nano 17 (2023) 4034–4049. doi: 10.1021/acsnano.3c00041
24. [24]
  C. Xu, Y. Jiang, Y. Han, et al., Adv. Mater. 33 (2021) 2008061. doi: 10.1002/adma.202008061
25. [25]
  X. Liu, X. Zhong, C. Li, Chin. Chem. Lett. 32 (2021) 2347–2358. doi: 10.1016/j.cclet.2021.03.015
26. [26]
  J. Xiong, M. Wu, J. Chen, et al., ACS Nano 15 (2021) 19756–19770. doi: 10.1021/acsnano.1c07180
27. [27]
  L. Rao, L. Wu, Z. Liu, et al., Nat. Comm. 11 (2020) 4909. doi: 10.1038/s41467-020-18626-y
28. [28]
  Y. Zhang, Y. Jiao, X. Jia, et al., Chin. Chem. Lett. 35 (2024) 108748. doi: 10.1016/j.cclet.2023.108748
29. [29]
  J. Park, Q. Jiang, D. Feng, et al., J. Am. Chem. Soc. 138 (2016) 3518–3525. doi: 10.1021/jacs.6b00007
30. [30]
  A.D. Garg, D.V. Krysko, T. Verfaillie, et al., EMBO J. 31 (2012) 1062–1079. doi: 10.1038/emboj.2011.497
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2. [2]
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11. [11]
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12. [12]
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13. [13]
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14. [14]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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